Rab3D: A regulator of exocytosis in non-neuronal cells

Histology and Histopathology

Volumn 17, Issue 3, 2002, Pages 929-936

  Millar, A L ^a   Pavlos, N J ^a   Xu, J ^a   Zheng, Ming Hao ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Exocytosis; Isoprenylation; Osteoclast; Rab3D; Vesicle transport

Indexed keywords

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; ISOPROTEIN; RAB PROTEIN; RAB3D PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

CARBOXY TERMINAL SEQUENCE; CELL TRANSPORT; CELL VACUOLE; CYTOPLASM; DOWNSTREAM PROCESSING; EFFECTOR CELL; EXOCYTOSIS; ISOPRENYLATION; MOLECULAR INTERACTION; NERVE CELL; NONHUMAN; PROTEIN STRUCTURE; REVIEW; SECRETORY GRANULE;

EID: 0036064457     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Genomic organization, chromosomal localization, and expression of the murine RAB3D gene
2. Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
3. Cloning of a Rab3 isotype predominately expressed in adipocytes
4. Nonneuronal expression of Rab3A: Induction during adipogenesis and association with different intracellular membranes than Rab3D
5. Expression of Rab3D N135I inhibits regulated secretion of ACTH in AtT-20 cells
6. Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4
7. Constitutive and regulated secretion of proteins
8. A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4
9. Differential expression of Rab3 isoforms in high- and low-secreting mast cell lines
10. Protein prenyltransferases
11. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
12. Expression and localization of rab escort protein isoforms in parotid acinar cells from rat
13. Hypervariable C-terminal domain of rab proteins acts as a targeting signal
14. Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants: Evidence that inhibitory effects are independent of direct interaction with Rabphilin3
15. Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP
16. Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis
17. REP-2, a Rab escort protein encoded by the choroideremia-like gene
18. Pathways to regulated exocytosis in neurons
19. Structural basis of activation and GTP hydrolysis in Rab proteins
20. Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4
21. Different Rab GTPases associate preferentially with alpha or beta GDP-dissociation inhibitors
22. Immunohistochemical localization and mRNA detection of Rab3D and/or Rab3B in rat von Ebner's glands, parotid gland, pancreas, and liver
23. GDP/GTP exchange reaction-stimulating activity of Rabphilin-3A for Rab3A small GTP-binding protein
24. Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins
25. SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modelling
26. Protein modelling for all
27. Cloning and localization of Rab3 isoforms in bovine, rat, and human parathyroid glands
28. The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis
29. Subcellular distribution and function of Rab3A, B, C and D isoforms in insulin-secreting cells
30. High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiation of stimulated secretion
31. Rab3D, a small GTP-binding protein implicated in regulated secretion, is associated with the transcytotic pathway in rat hepatocytes
32. Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C
33. Diffuse vesicular distribution of Rab3D in the polarized neuroendocrine cell line AtT-20
34. Rab3A and Rab3D control the total granule number and the fraction of granules docked at the plasma membrane in PC12 cells
35. Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain
36. Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic ras proteins
37. Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation
38. The diversity of Rab proteins in vesicle transport
39. RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells
40. Rab3D localises to zymogen granules in rat pancreatic acini and other exocrine glands
41. Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice
42. Role Rab GTPases in membrane traffic
43. Structural basis of rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of Rabphilin-3A
44. Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
45. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: Implications for the mechanism of GTP hydrolysis
46. Protein modeling by E-mail
47. The mammalian Rab family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
48. Expression of Rab3D in dispersed chief cells from guinea pig stomach
49. Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach
50. Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI)
51. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release
52. Rab geranylgeranyl transferase: A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys-Cys
53. Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin
54. Rab proteins and the road maps for intracellular transport
55. The N-terminal domain of a rab protein is involved in membrane-membrane recognition and/or fusion
56. Function of Rab3 GDP-GTP Exchange
57. Membrane fusion machinery: Insights from synaptic proteins
58. Small GTP-binding proteins
59. Rab3D protein is a specific marker for zymogen granules in gastric chief cells of rats and rabbits
60. Four additional members of the ras gene superfamily isolated of an oligonucleotide strategy: Molecular cloning of YPT-related cDNAs from a rat brain library
61. Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocystosis
62. Rab3D localizes to secretory granules in rat pancreatic acinar cells
63. Actin coating of secretory granules during regulated exocytosis correlates with the release of rab3D
64. 2+)-dependent exocytosis in PC12 cells
65. Isolation and characterization of GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins
66. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
67. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins
68. Association of Rab1B with GDP-dissociation inhibitor (GDI) is required for recycling but not initial membrane targeting of the Rab protein
69. Rab3D regulates vesicle fusion in osteoclasts