Structural basis for dimerization of the Grb10 Src homology 2 domain: Implications for ligand specificity

Journal of Biological Chemistry

Volumn 278, Issue 15, 2003, Pages 13257-13264

  Stein, Evan G ^a   Ghirlando, Rodolfo ^b   Hubbard, Stevan R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DIMERIZATION; INSULIN; PROTEINS; TUMORS;

LIGANDS;

BIOCHEMISTRY;

ASPARTIC ACID; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; INSULIN; PHOSPHOPEPTIDE; PLECKSTRIN; PROTEIN DERIVATIVE; PROTEIN GRB14; SOMATOMEDIN C RECEPTOR; TYROSINE; UNCLASSIFIED DRUG; VALINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GRB14 PROTEIN, HUMAN; GRB7 PROTEIN, HUMAN; LIGAND; PEPTIDE FRAGMENT; PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DIMERIZATION; GENETIC CONSERVATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SRC HOMOLOGY DOMAIN; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; ENZYME SPECIFICITY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SOLUTION AND SOLUBILITY; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GRB10 ADAPTOR PROTEIN; GRB7 ADAPTOR PROTEIN; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY;

EID: 0037969630     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212026200     Document Type: Article

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