The binding of human glial cell line-derived neurotrophic factor to heparin and heparan sulfate: Importance of 2-O-sulfate groups and effect on its interaction with its receptor, GFRα1

Glycobiology

Volumn 13, Issue 6, 2003, Pages 419-426

  Rickard, Steven M ^a,b   Mummery, Rosemary S ^b   Mulloy, Barbara ^c   Rider, Christopher C ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

GDNF; GFR 1 receptor; Glycosaminoglycan; Heparan sulfate; Heparin

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLYCOSAMINOGLYCAN; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; HEPARAN SULFATE; HEPARIN; POLYPEPTIDE; PROTEINASE; RECEPTOR SUBTYPE; SULFATE;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IC 50; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RECEPTOR BINDING; SULFATION;

EID: 0037942791     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/cwg046     Document Type: Article

References (31)

1. Baloh, R., Tansey, M., Lampe, P., Fahrner, T., Enomoto, H., Simburger, K., Leitner, M., Araki, T., Johnson, E., and Milbrandt, J. (1998) Artemin, a novel member of the GDNF ligand family supports peripheral and central neurons and signals through the GFRα3-Ret receptor. Neuron, 21, 1291-1302.
2. Baloh, R., Enomoto, H., Johnson, E., and Milbrandt, J. (2000) The GDNF family ligands and receptors - implications for neural development. Curr. Opin. Neurobiol., 10, 103-110.
3. Bullock, S., Fletcher, J., Beddington, R., and Wilson, V. (1998) Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev., 12, 1894-1906.
4. Cacalano, G., Farinas, I., Wang, L., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A., Reichardt, L., and others. (1998) GFRalpha1 is an essential receptor for GDNF in the developing nervous system and kidney. Neuron, 21, 53-62.
5. Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A., and Colliec-Jouault, S. (2001) A disaccharide repeat unit is the major structure of fucoidans from two species of brown algae. Carbohyd. Res., 330, 529-535.
6. Choi-Lundberg, D., Lin, Q., Chang, Y.-N., Chaing, Y., Hay, C., Mohajeri, H., Davidson, B., and Bohn, M. (1997) Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science, 275, 838-841.
7. Gallagher, J., Turnbull, J., and Lyon, M. (1992) Patterns of sulphation in heparan sulphate: polymorphism based on a common theme. Int. J. Biochem., 24, 553-560.
8. Hamilton, J., Morrison P., Chen, M., Harvey-White, J., Pernaute, R., Phillips, H., Oldfield, E., and Bankiewicz, K. (2001) Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neutrin. Exp. Neurol., 168, 155-161.
9. Hasan, M., Najjam, S., Gordon, M., Gibbs, R., and Rider, C. (1999) IL-12 is a heparin-binding cytokine. J. Immunol., 162, 1064-1070.
10. Kordower, J., Emborg, M., Bloch, J., Ma, S., Chu, Y., Leventhal, L., McBride, J., Chen, E., Palfi, S., Roitberg, B., and others. (2000) Neurodegeneration prevented by lentiviral delivery of GDNF in primate models of Parkinson's disease. Science, 290, 767-773.
11. Kotzbauer, P., Lampe, P., Heuckeroth, R., Golden, J., Creedon, D., Johnson, E., and Milbrandt, J. (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature, 384, 467-470.
12. Lin, L.-F., Doherty, D., Lile, J., Bektesh, S., and Collins, F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science, 260, 1130-1132.
13. Lin L.-F., Zhang, T., Collins, F., and Armes, L. (1994) Purification and initial characterization of rat B49 glial line-derived neurotrophic factor. J. Neurochem., 63, 758-768.
14. Lindalhl, U., Lidholt, K., Spillmann, D., and Kjellen, L. (1994) More to "heparin" than anticoagulation. Thromb. Res., 75, 1-32.
15. Major, S. (2002) New treatment improves symptoms of Parkinson's disease. Brit. Med. J., 324, 997.
16. Milbrandt, J., de Sauvage, F., Fahrner, T., Baloh, R., Leitner, M., Tansey, M., Lampe, P., Heuckeroth, R., Kotzbauer, P., Simburger, K., and others. (1998) Persephin, a novel neurotrophic factor related to GDNF and neuturin. Neuron, 20, 245-253.
17. Moore, M., Klein, R., Farinas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L., Ryan, A., Carver-Moore, K., and Rosenthal, A. (1996) Renal and neuronal abnormalities in mice lacking GDNF. Nature, 382, 76-79.
18. Mulloy, B., Forster, M., Jones, C., Drake, A., Johnson E., and Davies D. (1994) The effect of substitution on the solution conformation of heparin: a spectroscopic and molecular modelling study. Carbohyd. Res., 255, 1-26.
19. Mummery, R. and Rider, C. (2000) Characterization of the heparin-binding properties of IL-6. J. Immunol., 165, 5671-5679.
20. Najjam, S., Gibbs, R., Gordon, M., and Rider, C. (1997) Characterisation of human recombinant interleukin 2 binding to heparin and heparan sulphate using an ELISA approach. Cytokine, 9, 1013-1022.
21. Najjam, S., Mulloy, B., Theze, J., Gordon, M., Gibbs, R., and Rider, C. (1998) Further characterisation of the binding of human recombinant interleukin 2 to heparin and identification of putative binding sites. Glycobiology, 8, 509-516.
22. Ostrovsky, O., Berman, B., Gallagher, J., Mulloy, B., Fernig, D., Delehedde, M., and Ron, D. (2002) Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes. J. Biol. Chem., 277, 2444-2453.
23. Patankar, M., Oehninger, S., Barnett, T., Williams, R., and Clark, G. (1993) A revised structure for fucoidan may explain some of its biological activities. J. Biol. Chem., 267, 21770-21776.
24. Pichel, J., Shen, L., Sheng, H., Granholm, A.-C., Drago, J., Grinberg, A., Lee, E., Huang, S., Saarma, M., Hoffer, B., and others. (1996) Defects in enteric innervation and kidney development in mice lacking GDNF. Nature, 382, 73-76.
25. Rider, C., Coombe, D., Harrop, H., Hounsell, E., Bauer, C., Feeney, J., Mulloy, B., Mahmood, N., Hay, A., and Parish, C. (1994) Anti-HIV-1 activity of chemically modified heparins: correlation between binding to the V3 loop of gp120 and inhibition of cellular HIV-1 infection in vitro. Biochemistry, 33, 6974-6980.
26. Sanchez, M., Silos-Santiago, I., Frisen, J., He, B., Lira, S., and Barbacid, M. (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature, 382, 70-73.
27. Schedl, A. and Hastie, N. (2000) Cross-talk in kidney development. Curr.t Opin. Genet. Dev., 10, 534-549.
28. Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F., and Pachnis, V. (1994) Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature, 367, 380-383.
29. Shively J. and Conrad, J. (1976) Formation of anhydrosugars in the chemical depolymerization of heparin. Biochemistry, 15, 3932-3942.
30. Tomac, A., Grinberg, A., Huang, S., Nosrat, C., Wang, Y., Borlongan, C., Lin, S.-Z., Chiang, Y.-H., Olson, L., Westphal, H., and Hoffer, B. (2000) Glial cell-line derived neurotrophic factor receptor alpha1 availability regulates glial cell-line derived neurotrophic factor signalling: evidence from mice carrying one or two mutated alleles. Neuroscience, 95, 1011-1023.
31. 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. Carbohyd. Res., 294, 15-27.