IL-12 is a heparin-binding cytokine

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 1064-1070

  Hasan, Maemunah ^a   Najjam, Saloua ^a   Gordon, Myrtle Y ^b   Gibbs, Roslyn V ^c   Rider, Christopher C ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GLYCOSAMINOGLYCAN; HEPARIN; HEPARIN LYASE; INTERLEUKIN 12;

ARTICLE; BINDING AFFINITY; IMMUNOSTIMULATION; MOLECULAR INTERACTION; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CATTLE; CYTOKINES; DALTEPARIN; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCOSAMINOGLYCANS; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HEPARITIN SULFATE; HUMANS; INTERLEUKIN-12; INTESTINAL MUCOSA; MICE; NADROPARIN; RECOMBINANT PROTEINS; SERUM ALBUMIN, BOVINE; SWINE;

EID: 0033555412     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewiek, et al. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple effects on T and natural killer cells. J. Immunol. 146:3074.
2. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad Sci. USA 88:4143.
3. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulalory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
4. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
5. Magram, J., S. E. Connaughton, R. R. Warner, D. M. Carvajal, C.-y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses. Immunity 4:471.
6. Afonso, L. C. C., T. M. Scharton, L. Q. Vierira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
7. Mattner, F., J. Magram, J. Ferrante, P. Launios, K. Di Padova, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553.
8. Hoffman, S. L., J. M. Crutcher, S. K. Pun, A. A. Ansari, F. Villinger, E. D. France, P. P. Singh, F. Finkelman, M. K. Gately, G. P. Dutta, and M. Sedegah. 1997. Sterile protection of monkeys against malaria after administration of interleukin-12. Nat. Med. 3:80.
9. Chougent, C., and G. M. Shearer. 1996. Potential clinical applications of interleukin-12. Curr. Opin. Hematol. 3:216.
10. Rossol, S., G. Marinas, P. Carucci, M. V. Singer, R. Williams, and N. V. Naoumov. 1997. Interleukin-12 induction of the Th1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99:3025.
11. Lortat Jacob, H., and J.-A. Grimaud. 1991. Interferon-γ binds to heparan sulfate by a cluster of amino acids located in the C-terminal part of the molecule. FEBS Letts. 280:152.
12. Lortat-Jacob, H., J. E. Turnbull, and J.-A. Grimaud. 1995. Molecular organisation of the interferon γ-binding domain in heparan sulphate. Biochem. J. 310:497.
13. Najjam, S., R. V. Gibbs, M. Y. Gordon, and C. C. Rider. 1997. Characterization of human recombinant interleukin 2 binding to heparin and heparan sulfate using an ELISA approach. Cytokine 9:1013.
14. Najjam, S., B. Mulloy, J. Theze, M. Gordon, R. Gibbs, and C. C. Rider. 1998. Further characterization of the binding of human recombinant interleukin 2 to heparin and identification of putative binding sites. Glycobiology. 8:509.
15. Johnson, E. A. 1984. Heparan sulfates from porcine intestinal mucosa: preparation and physicochemical properties. Thrombosis Res. 35:583.
16. Carter, R. W., P. M. Patel, A. J. Stanley, E. Ingham, M. Wadhwa, C. Bird, R. Thorpe, P. J. Selby, and R. E. Banks. 1997. Production and characterization of monoclonal antibodies to human interleukin-12. Hybridoma 16:363.
17. Rider, C. C. 1998. Analysis of glycosaminoglycans and proteoglycans. In Methods in Molecular Biology, Vol. 76. Glycoanalysis Protocols. E. F. Hounsell, ed. The Humana Press, Totowa, NJ, p. 131-144.
18. Shively, J. E., and H. E. Conrad. 1976. Formation of anhydrosugars in the chemical depolymerisation of heparin. Biochemistry 15:3932.
19. Casu, B., M. Petitou, M. Provasoli, and P. Sinay. 1988. Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans. Trends Biochem. Sci. 13:221.
20. Yanagishita, M., and V. C. Hascall. 1992. Cell surface heparan sulfate proteoglycans. J. Biol. Chem. 267:9451.
21. Patankar, M. S., S. Oehninger, T. Barnett, R. L. Williams, and G. F. Clark. 1993. A revised structure for fucoidan may explain some of its biological activities. J. Biol. Chem. 268:21770.
22. Linhardt, R. J., J. E. Turnbull, H. M. Wang, D. Loganathan, and J. T. Gallagher. 1990. Examination of the substrate specificity of heparin and heparan sulfate lyases. Biochemistry 29:2611.
23. Tyrell, D. J., M. Ishihara, R. Narasinga, A. Horne, M. C. Kiefer, G. B. Stauber, L. H. Lam, and R. J. Stack. 1993. Structure and biological activities of a heparin-derived hexasaccharide with high affinity for basic fibroblast growth factor. J. Biol. Chem. 268:4684.
24. Maccarana, M., B. Casu, and U. Lindahl. 1993. Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor. J. Biol. Chem. 268:23898.
25. Tumbull, J. E., D. G. Fernig, Y. Ke, M. C. Wilkinson, and J. T. Gallagher. 1992. Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate. J. Biol. Chem. 267:10337.
26. Toida, T., H. Yoshida, H. Toyoda, I. Koshiishi, T. Imanari, R. E. Hileman, J. R. Fromm, and R. J. Linhardt. 1997. Structural differences and the presence of unsubstituted amino groups in heparan sulfates from different tissues and species. Biochem. J. 322:499.
27. Lindahl, U., L. Thunberg, G. Backstrom, J. Riesenfeld, K. Nordling, and I. Bjork. 1984. Extension and structural variability of the antithrombin-binding sequence in heparin. J. Biol. Chem. 259:12368.
28. Stringer, S. E., and J. T. Gallagher. 1997. Specific binding of the chemokine platelet factor 4 to heparan sulfate. J. Biol. Chem. 272:20508.
29. Merberg, D. M., S. F. Wolf, and S.C. Clark. 1992. Sequence similarity between NSKSF and the IL-6/G-CSF family. Immunol. Today 13:77-78.
30. Gearing, D. P., and D. Cosman. 1991. Homology of the p40 subunit of natural killer stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66:9.
31. Spillman, D., and U. Lindahl. 1994. Glycosaminoglycan-protein interactions: a question of specificity. Curr. Opin. Struct. Biol. 4:677.
32. Schoenhaut, D. S., A. O. Chua, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J. Immunol. 148:3433.
33. Webb, L.M.C., M. U. Ehrengruber, I. Clark-Lewis, M. Bagglioni, and A. Rot. 1993. Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc. Natl. Acad. Sci. USA 90:7158.
34. Witt, D.P., and A. Lander. 1994. Differential binding of chemokines to glycosaminoglycan subpopulations. Curr. Biol. 4:394.
35. Watton, J., C. Longstaff, D. A. Lane, and T. W. Barrowcliffe. 1993. Heparin binding affinity of normal and genetically modified antithrombin III measured using a monoclonal antibody to the heparin binding site of antithrombin III. Biochemistry 32:7286.
36. Lee, M. K., and A. D. Lander. 1991. Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic technique. Proc. Natl. Acad. Sci. USA 88:2768.
37. Stevens, R.L. 1987. Intracellular proteoglycans of the immune system. In Biology of Proteoglycans. T. N. Wight and R. P. Mehan, eds. Academic Press, Orlando, FL. p. 367-387.
38. Reis e Sousa, C., S. Heiny, T. Scharton-Kersten, D. Jankovic, H. Charest, R. N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819.
39. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901.