Prompt and Delayed Nonsteroidal Anti-inflammatory Drug-photoinduced DNA Damage in Peripheral Blood Mononuclear Cells Measured with the Comet Assay

Photochemistry and Photobiology

Volumn 77, Issue 4, 2003, Pages 390-396

  Vinette, Anne L ^a   McNamee, James P ^b   Bellier, Pascale V ^b   McLean, J R N ^b   Scaiano, J C ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYL RADICAL; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; TIAPROFENIC ACID;

ARTICLE; COMET ASSAY; CROSS LINKING; DEAMINATION; DNA DAMAGE; DNA MODIFICATION; MONONUCLEAR CELL; PHOTOCHEMISTRY; PROTEIN DNA INTERACTION; RADIATION ABSORPTION; RADIATION EXPOSURE; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ANIMAL; DRUG EFFECT; METABOLISM; MONOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COMET ASSAY; DNA DAMAGE; MONOCYTES;

EID: 0037869019     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2003)077<0390:PADNAD>2.0.CO;2     Document Type: Article

References (48)

1. Billen, D. (1990) Spontaneous DNA damage and its significance for the "negligible dose" controversy in radiation protection. Radiat. Res. 124, 242-245.
2. Coohill, T. P. (1995) In Action Spectroscopy: Ultraviolet Radiation (Edited by W. M. Horspool and P. S. Song), pp. 1267-1275. CRC Press, Inc., Boca Raton, Fl.
3. Burrows, C. J. and J. G. Muller (1998) Oxidative nucleobase modifications leading to strand scission. Chem. Rev. 98, 1109-1151.
4. Kan, L.-S., L. Voituriez and J. Cadet (1992) The Dewar valence isomer of the (6-4) photoadduct of thymidylyl-(3′-5′)-thymidine monophosphate: formation, alkaline lability and conformations properties. J. Photochem. Photobiol. B: Biol. 12, 339-357.
5. Franklin, W. A., K. M. Lo and W. A. Haseltine (1982) Alkaline lability of fluorescent photoproducts produced in ultraviolet light-irradiated DNA. J. Biol. Chem. 257, 13535-13543.
6. Cadet, J. (1994) In Identification and Biological Significance (Edited by A. Hemminki, A. Dipple, D. E. G. Shuker, F. F. Kadlubar, D. Segerback and H. Bartsch). IARC Scientific, Lyon, France.
7. Woollons, A., P. H. Clingen, M. L. Price, C. F. Arlett and M. H. L. Green (1997) Induction of mutagenic DNA damage in human fibroblasts after exposure to artificial tanning lamps. Br. J. Dermatol. 137, 687-692.
8. Peak, M. J. and J. G. Peak (1995) In Photosensitized Reactions of DNA in CRC Handbook of Organic Photochemistry, and Photobiology (Edited by W. M. Horspool and P. S. Song), pp. 1318-1325. CRC Press, Inc., Kentucky.
9. Cadet, J. and P. Vigny (1990) In Bioorganic Photochemistry, Vol. I (Edited by H. Morrison), pp. 1-272. Wiley, New York.
10. Lu, X., D. W. Fairbairn, W. S. Bradshaw, K. L. O'Neil, D. L. Ewert and D. L. Simmons (1997) NSAID-induced apoptosis in rous sarcoma virus-transformed chicken embryo fibroblasts is dependent on v-src and e-mye and is inhibited by bcl-2. Prostaglandins 54, 549-568.
11. Alomar, A. (1985) Ketoprofen photodermatitis. Contact Dermatitis 12, 112-113.
12. Condorelli, G., L. L. Costanzo, G. De Guidi, S. Giuffrida, P. Miano, S. Sortino and A. Velardita (1996) Photosensitization induced by non steroidal anti inflammatory drugs: an overview of molecular mechanisms in biological systems. Newsletter 58, 66-77.
13. Shah, A. K., G. Wei, R. C. Lanman, V. O. Bhargava and S. J. Weir (1996) Percutaneous absorption of ketoprofen from different anatomical sites in man. Pharm. Res. 13, 168-172.
14. Skeith, K. J., A. S. Russell and F. Jamali (1993) Ketoprofen pharmacokinetics in the elderly: influence of rheumatic disease, renal function, and dose. J. Clin. Pharmacol. 33, 1052-1159.
15. Cusano, F., B. R. Rafenella and G. Errico (1987) Photo-contact dermatitis from ketoprofen. Contact Dermatitis 17, 108-109.
16. Totsi, A., G. Gaddoni, F. Valeri and F. Bardazzi (1990) Contact allergy to ketoprofen. Contact Dermatitis 23, 112-113.
17. Mozzanica, N. and P. D. Pigato (1990) Contact and photocontact allergy to ketoprofen: clinical and experimental study. Contact Dermatitis 23, 336-340.
18. Ljunggren, B. (1985) Propionic acid-derived non-steroidal anti-inflammatory drugs are phototoxic in vitro. Photodermatology 2, 3-9.
19. Costanzo, L. L., G. De Guidi, G. Condorelli, A. Cambria and M. Fama (1989) Molecular mechanism of drug photosensitization-II. Photohemolysis sensitized by ketoprofen. Photochem. Photobiol. 50, 359-365.
20. Boscá, F., G. Carganico, J. V. Castell, M. J. Gó mez-Lechón, D. Hernandez, D. Mauleón, L. A. Martínez and M. A. Miranda (1995) Evaluation of ketoprofen (R, S and R/S) phototoxicity by a battery of in vitro assays. J. Photochem. Photobiol. B: Biol. 31, 133-138.
21. Boscá, F., M. A. Miranda, G. Carganico and D. Mauleón (1994) Photochemical and photobiological properties of ketoprofen associated with the benzophenone chromophore. Photochem. Photobiol. 60, 96-101.
22. Chignell, C. F. and R. H. Sik (1995) Magnetic field effects on the photohemolysis of human erythrocytes by ketoprofen and protoporphyrin IX. Photochem. Photobiol. 62, 205-207.
23. Hilleman, B. (1993) Health effects of electromagnetic fields remain unsolved. Chem. Eng. News 15-29.
24. Artuso, T., J. Bernadou, B, Meunier and N. Paillous (1990) DNA strand breaks photosensitized by benoxaprofen and other nonsteroidal antiinflammatory agents. Biochem. Pharmacol. 39, 407-413.
25. Artuso, T., J. Bernadou, B. Meunier, J. Piette and N. Paillous (1991) Mechanism of DNA cleavage mediated by photoexcited non-steroidal antiinflammatory drugs. Photochem. Photobiol. 54, 205-213.
26. Chouini-Lalanne, N., M. Defais and N. Paillous (1998) Nonsteroidal antiinflammatory drug-photosensitized formation of pyrimidine dimer in DNA. Biochem. Pharmacol. 5, 441-446.
27. De Guidi, G., S. Giuffrida, G. Condorelli, L. L. Costanzo, P. Miano and S. Sortino (1996) Molecular mechanism of drug photosensitization. IX. Effect of inorganic ions on DNA cleavage photosensitized by naproxen. Photochem. Photobiol. 63, 455-462.
28. Martínez, L. J. and J. C. Scaiano (1998) Characterization of the transient intermediates generated from the photoexcitation of nabumetone: a comparison with naproxen. Photochem. Photobiol. 68, 646-651.
29. Monti, S., S. Sortino, G. De Guidi and G. Marconi (1997) Photochemistry of 2-(3-benzoylphenyl)propionic acid (ketoprofen). Part I. A picosecond and nanosecond time resolved study in aqueous solution. J. Chem. Soc. Faraday Trans. 93, 2269-2275.
30. Borsarelli, C. D., S. E. Braslavsky, S. Sortino, G. Marconi and S. Monti (2000) Photodecarboxylation of ketoprofen in aqueous solution. A time-resolved laser-induced optoacoustic study. Photochem. Photobiol. 72, 163-171.
31. Cosa, G., L. J. Martínez and J. C. Scaiano (1999) Influence of solvent polarity and base concentration on the photochemistry of ketoprofen: independent singlet and triplet pathways. Phys. Chem. Chem. Phys. 1, 3533-3537.
32. Martínez, L. J. and J. C. Scaiano (1997) Transient intermediates in the laser flash photolysis of ketoprofen in aqueous solutions: unusual photochemistry for the benzopheneone chromophore. J. Am. Chem. Soc. 119, 11066-11070.
33. Boscá, F., M. L. Marín and M. A. Miranda (2001) Photoreactivity of the nonsteroidal anti-inflammatory 2-arylpropionic acids with photosensitizing side effects. Photochem. Photobiol. 74, 637-655.
34. Chignell, C. F. and R. H. Sik (1998) The effect of static magnetic fields on the photohemolysis of human erythrocytes by ketoprofen. Photochem. Photobiol. 67, 591-595.
35. Hölzle, E., N. Newmann, B. Hausen, B. Przybilla, S. Schauder, H. Hönigsmann, A. Bircher and G. Plewig (1991) Photopatch testing: the five year experience of the German, Austrian and Swiss photopatch test group. J. Am. Acad. Dermatol. 25, 59-68.
36. Diffey, B. L., T. J. Daymond and H. Fairgreaves (1983) Phototoxic reaction to Piroxicam, Naproxen and Tiaprofenic acid. Br. J. Rheumatol. 22, 239-242.
37. Neumann, R. A., R. M. Knobler and H. Lindmayr (1989) Tiaprofenic acid induced photosensitivity. Contact Dermatitis 20, 270-273.
38. Encinas, S., M. A. Miranda, G. Marconi and S. Monti (1998) Triplet photoreactivity of the diaryl ketone tiaprofenic acid and its decarboxylated photoproduct. Photobiological implications. Photochem. Photobiol. 67, 420-425.
39. Encinas, S., M. A. Miranda, G. Marconi and S. Monti (1998) Transient species in the photochemistry of tiaprofenic acid and its decarboxylated photoproduct. Photochem. Photobiol. 68, 633-639.
40. Diffey, B. L. and S. Brown (1983) A method for predicting the phototoxicity of non-steroidal anti-inflammatory drugs. Br. J. Pharmacol. 16, 633-638.
41. Agapakis-Caussé, V., F. Boscá, J. V. Castell, D. Hernández, M. L. Marín, L. Marrot and M. A. Miranda (2000) Tiaprofenic acid-photosensitized damage to nucleic acids: a mechanistic study using complementary in vitro approaches. Photochem. Photobiol. 71, 499-505.
42. Strauss, G. H. (1991) Non-random cell killing in cryopreservation for performance of the battery of leukocyte tests (BLT), I. Toxic and immunotoxic effects. Mutat. Res. 252, 1-15.
43. Deninger, M. J. and R. D. Schoenwald (2000) Uptake of ibuprofen, indomethacin and ketoprofen into isolated rabbit parietal cells. J. Pharm. Pharmacol. 52, 501-509.
44. Olive, P. L., J. P. Banáth and P. E. Durand (1990) Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. J. Natl. Cancer. Inst. 82, 779-783.
45. McNamee, J. P., P. V. Bellier, J. R. N. McLean, L. Marro, G. B. Gajda and A. Thansandote (2001) DNA damage and apoptosis in the immature mouse cerebellum after acute exposure to a 1 mT, 60 Hz magnetic field. Mutat. Res. 513, 121-133.
46. Reinhardt-Poulin, P., J. R. McLean, Y. Deslauriers, W. Gorman, S. Cabat and M. Rouabhia (2000) The use of silver-stained "comets" to visualize DNA damage and repair in normal and Xeroderma pigmentosum fibroblasts after exposure to simulated solar radiation. Photochem. Photobiol. 71, 422-425.
47. Singh, N. P., R. E. Stephens and E. L. Schneider (1994) Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int. J. Radiat. Biol. 66, 23-28.
48. Banáth, J. P., A. Kim and P. L. Olive (2001) Overnight lysis improves the efficiency of detection of DNA damage in the alkaline comet assay. Radiat. Res. 155, 564-571.