Uptake of ibuprofen, indomethacin and ketoprofen into isolated rabbit parietal cells

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 5, 2000, Pages 501-509

  Deninger, Michael J ^a   Schoenwald, Ronald D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; IBUPROFEN; INDOMETACIN; KETOPROFEN; NIGERICIN; SODIUM; SODIUM AZIDE;

ACTIVE TRANSPORT; ADSORPTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SOLUBILITY; DRUG UPTAKE; LOW TEMPERATURE; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PASSIVE TRANSPORT; PH; RABBIT; STOMACH PARIETAL CELL; TEMPERATURE DEPENDENCE;

EID: 0034037414     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774282     Document Type: Article

References (25)

1. 2/Ra)-Purinoceptors may mediate the stimulatory effect of adenosine and adenosine analogs on acid formation in isolated rabbit parietal cells. Pharmacol. Res. 27: 319-333
2. Berglindh, T. (1985) Improved one-step purification of isolated gastric parietal cells from rabbit and dog. Fed. Proc. (Abstr) 44: 616
3. Berglindh, T., Öbrink, K. (1976) A method for preparing isolated glands from the rabbit gastric mucosa. Acta Physiol. Scand. 96: 150-159
4. Bradford, M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72: 449-454
5. Brune, K. (1985) Rationale and success of modifying the absorption of antiinflammatory drugs to reduce the gastrointestinal side-effects. Adv. Inflamm. Res. 10: 391-394
6. Brune, K., Graf, P. (1978) Non-steroid anti-inflammatory drugs: influence of extracellular pH on biodistribution and pharmacological effects. Biochem. Pharmacol. 27: 525-530
7. Brune, K., Schweitzer, A., Lanz, R. (1984) Importance of drug biodistribution and metabolism in the development of side-effects by antiinflammatory/analgesic drugs. Adv. Inflamm. Res. 6: 9-15
8. Chikale, P., Borchardt, R. (1994) Metabolism of L-α-methyldopa in cultured human intestinal epithelial (CACO-2) cell monolayers: comparison with metabolism in vivo. Drug Metab. Dispos. 22: 592-599
9. Gengos, D. (1978) Long term experience with sulindac in the treatment of osteoarthritis. Eur. J. Rheumatol. Inflamm. 1: 168-178
10. Herzfeldt, C., Kümmel, R. (1983) Dissociation constants, solubilities and dissolution rates of some selected nonsteroidal antiinflammatories. Drug Dev. Ind. Pharm. 9: 767-793
11. Inui, K., Yamamoto, M., Saito, H. (1992) Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line caco-2: specific transport systems in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 261: 195-201
12. Kazatchkine, M., Fearon, T., Austen, K. (1979) Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and β1H for cell-bound C3b. J. Immunol. 122: 75-81
13. Lussier, A., LeBel, E. (1987) Radiochromium (chromium0-51) evaluation of gastrointestinal blood loss associated with placebo, aspirin and nabuetone. Am. J. Med. 83(Suppl. 4B): 15-18
14. Mazzeo, R., Nandi, J., Levine, R. (1988) Effect of ethanol on parietal cell membrane phospholipids and proton pump function. Am. J. Physiol. 254: G57-G64
15. McCormack, K., Brune, K. (1987) Classical absorption theory and the development of gastric and mucosal damage associated with the nonsteroidal antiinflammatory drugs. Arch. Toxicol. 60: 261-269
16. Pease, C., Storr, J., Earle, J., Barnardo, D. ( 1985) Endoscopic, histological, and clinical assessment of two non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis. In: Panayi, G. S., Price, J. D., Rotman, H. (eds) Royal Society of Medicine International Congress and Symposium Series, The Royal Society of Medicine, London, 69, pp 105-112
17. Rainsford, K. D. (1975) Lectromicroscopic observations of the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat. Gut 16: 514-527
18. Rainsford, K. D. (1977) The comparative gastric ulcerogenic activities of nonsteroid anti-inflammatory drugs. Agents Actions 5: 573-577
19. Rainsford, K. D. (1984) Aspirin and the Salicylates. Butterworth & Co., Norfolk, pp 148-222
20. Rainsford, K. D., Brune, K. (1978) Selective cytotoxic actions of aspirin on parietal cells: a principle factor in the early stages of aspirin gastric damage. Arch. Toxicol. 40: 143-150
21. Rhymer, A. (1979) Sulindac. Clin. Rheum. Dis. 5: 553-568
22. Robinson, D. (1983) Pharmacokinetics and pharmacodynamics of drug delivery. Curr. Med. Res. Opin. 8(Suppl. 2): 10-19
23. Somerville, K., Faulkner, G., Langman, M. (1986) Non-steroidal antiinflammatory drugs and bleeding peptic ulcer. Lancet 1: 462-464
24. Tsuji, A., Takanga, H., Tamai, I., Terasake, T. (1994) Transcellar transport of benzoic acid across caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res. 11: 30-37
25. Ward, C., Schirmer, R. (1977) Fenoprofen. In: Florey, K. (ed) Analytical Profiles of Drug Substances. Academic Press, New York, pp 162-182