Characterization of the Transient Intermediates Generated from the Photoexcitation of Nabumetone: A Comparison with Naproxen

Photochemistry and Photobiology

Volumn 68, Issue 5, 1998, Pages 646-651

  Martínez, Lydia J ^a   Scaiano, J C ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANONE; NABUMETONE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OXYGEN; PHOTOSENSITIZING AGENT; SINGLET OXYGEN;

ARTICLE; CHEMISTRY; COMPARATIVE STUDY; METHODOLOGY; SPECTROFLUOROMETRY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUTANONES; NAPROXEN; OXYGEN; PHOTOSENSITIZING AGENTS; SINGLET OXYGEN; SPECTROMETRY, FLUORESCENCE;

EID: 0032214758     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1998.tb02524.x     Document Type: Conference Paper

References (22)

1. Lister, B. J., M. Poland and R. E. DeLapp (1993) Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. Am. J. Med. 95, 2S-9S.
2. Carryl, O. R. (1995) Comparative effects of nabumetone, naproxen, piroxicam, and diclofenac on rat gastric irritancy following acute exposure to OTC non-steroidal anti-inflammatory agents and other gastric irritants. Scand. J. Rheumatol. 24, 336-341.
3. Porro, G. B., F. Montrone, M. Petrillo, I. Caruso and V. Imbesi (1995) Gastroduodenal tolerability of nabumetone versus naproxen in the treatment of rheumatic patients. Am. J. Gastroenterol. 90, 1485-1488.
4. Miwa, L. J., J. K. Jones, A. Pathiyal and H. Hatoum (1997) Value of epidemiologic studies in determining the true incidence of adverse events - the nonsteroidal anti-inflammatory drug story. Arch. Int. Med. 157, 2129-2136.
5. Dahl, S. L. (1993) Nabumetone: a "nonacidic" nonsteroidal antiinflammatory drug. Ann. Pharmacother. 27, 456-463.
6. Scaiano, J. C. (1980) Solvent effects in the photochemistry of xanthone. J. Am. Chem. Soc. 102, 7747-7753.
7. Scaiano, J. C., M. Tanner and D. Weir (1985) Exploratory study of the intermolecular reactivity of excited diphenylmethyl radicals. J. Am. Chem. Soc. 107, 4396-4403.
8. Wilkinson, F., W. P. Helman and A. B. Ross (1993) Quantum yields for the photosensitized formation of the lowest electronically excited singlet state of molecular oxygen in solution. J. Phys. Cliem. Ref. Data 22, 113-262.
9. g) sensitization. J. Photochem. Photobiol. A Chem. 79, 11-17.
10. Eaton, D. F. (1989) Luminescence spectroscopy. In Handbook of Organic Photochemistry, Vol. I (Edited by J. C. Scaiano), pp. 231-240. CRC Press, Boca Raton, FL.
11. Turro, N. J. (1978) Modern Molecular Photochemistry. Benjamin/Cummings Publishing Co., Menlo Park, CA.
12. Wagner, P. J. (1971) 1-Methylnaphthalene-sensitized singlet state reactions of aliphatic ketones. Mol. Photochem. 3, 169-173.
13. Moore, D. E. and P. P. Chappuis (1988) A comparative study of the photochemistry of the non-steroidal anti-inflammatory drugs, naproxen, benoxaprofen and indomethacin. Photochem. Photobiol. 47, 173-180.
14. Carmichael, I. and G. L. Hug (1989) Spectroscopy and intramolecular photophysics of triplet states. In Handbook of Organic Photochemistry, Vol. 1 (Edited by J. C. Scaiano), pp. 369-404. CRC Press, Boca Raton, FL.
15. Carmichael, I. and G. L. Hug (1986) Triplet-triplet absorption spectra of organic molecules in condensed phases. J. Phys. Chem. Ref. Data 15, 1-250.
16. Redmond, R. W. and S. E. Braslavsky (1988) Time-resolved thermal lensing and phosphorescence studies on photosensitized singlet molecular oxygen formation. Influence of the electronic configuration of the sensitizer on sensitization efficiency. Chem. Phys. Lett. 148, 523-529.
17. -: formation and reactions studied by laser flash photolysis. J. Chem. Soc. Perkin Trans. 2., pp. 335-342.
18. Wagner, P. J., P. A. Kelso and A. E. Kemppainen (1970) Deactivation of ketone triplets by b-phenyl substitution. Mol. Photochem. 2, 81-85.
19. Stermitz, F. R., D. E. Nicodem, V. P. Muralidharan and C. M. O'Donnell (1970) The photoreduction of benzylacetophenone and an attempted photoreduction of benzylacetone. Mol. Photochem. 2, 87-89.
20. Netto-Ferreira, J. C., W. J. Leigh and J. C. Scaiano (1985) Laser flash photolysis study of the photochemistry of ring substituted b-phenylpropiophenones. J. Am. Chem. Soc. 107, 2617-2622.
21. Whitten, D. G. and W. E. Punch (1970) Excited-state carbonylphenyl interactions in nonconjugated aryl ketones. Mol. Photochem. 2, 77-80.
22. Budac, D. and P. Wan (1992) Photodecarboxylation: mechanism and synthetic utility. J. Photochem. Photobiol. A Chem. 67, 135-166.