Structural and functional characterization of the human DNA repair helicase XPD by comparative molecular modeling and site-directed mutagenesis of the bacterial repair protein UvrB

Journal of Biological Chemistry

Volumn 278, Issue 7, 2003, Pages 5309-5316

  Bienstock, Rachelle J ^a   Skorvaga, Milan ^a,b   Mandavilli, Bhaskar S ^a   Van Houten, Bennett ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BACTERIA; CATALYST ACTIVITY; CRYSTAL STRUCTURE; DISEASES; DNA; MUTAGENESIS;

MUTATIONS;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATASE; ASPARTIC ACID; BACTERIAL PROTEIN; DNA; HELICASE; HISTIDINE; PROTEIN UVRB; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP D PROTEIN; DNA BINDING PROTEIN; ERCC2 PROTEIN, HUMAN; ESCHERICHIA COLI PROTEIN; PROTEIN; TRANSCRIPTION FACTOR; UVRB PROTEIN, E COLI;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DENATURATION; ENZYME ACTIVITY; ENZYME STRUCTURE; EXCISION REPAIR; GENE MUTATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FOLDING; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; THERMUS THERMOPHILUS; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DNA REPAIR; HUMAN; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); MAMMALIA; THERMUS; THERMUS THERMOPHILUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; ESCHERICHIA COLI PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEINS; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 0037799262     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210159200     Document Type: Article

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