ADAM 33: Just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?

Thorax

Volumn 58, Issue 6, 2003, Pages 466-469

  Holgate, S T ^a   Davies, D E ^a   Murphy, G ^a   Powell, R M ^a   Holloway, J W ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; PROTEIN ADAM 33; UNCLASSIFIED DRUG;

ASTHMA; BRONCHUS HYPERREACTIVITY; GENE IDENTIFICATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAM PROTEINS; ASTHMA; BRONCHIAL HYPERREACTIVITY; EXONS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METALLOENDOPEPTIDASES;

EID: 0037794414     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.58.6.466     Document Type: Review

References (49)

1. Carroll N, Lehmann E, Barret J, et al. Variability of airway structure and inflammation in normal subjects and in cases of nonfatal and fatal asthma. Pathol Res Pract 1996;192:238-48.
2. Juniper EF, Kline PA, Vanzieleghem MA, et al. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis 1990;142:832-6.
3. James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6.
4. Wiggs BR, Moreno R, Hogg JC, et al. A model of the mechanics of airway narrowing. J Appl Physiol 1990; 69:849-60.
5. Lambert RK, Wiggs BR, Kuwano K, et al. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993;74:2771-81.
6. Fredberg JJ. Airway smooth muscle in asthma: flirting with disaster. Eur Respir J 1998;12:1252-6.
7. Klinke DJ, Lewis AK, Wang S-P, et al. Airway hyperresponsiveness: exploration of mechanisms using a dynamic, computer-based model of asthma. Am J Respir Crit Care Med 2001;163:A832.
8. Duffy DL, Martin NG, Battistutta D, et al. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis 1990;142:1351-8.
9. Jenkins MA, Hopper JL, Giles GG. Regressive logistic modeling of familial aggregation for asthma in 7394 population-based nuclear families. Genet Epidemiol 1997;14:317-32.
10. Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM-33 gene with asthma and bronchial hyper-responsiveness. Nature 2002;418:426-30.
11. Kruglyak L, Lander ES. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 1995;11:241-7.
12. Cookson WO, Ubhi B, Lawrence R, et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nature Genet 2001;27:372-3.
13. Xu J, Meyers DA, Ober C, et al. Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three US populations: collaborative study on the genetics of asthma. Am J Hum Genet 2001;68:1437-46.
14. Howard TD, Meyers DA, Ampleford EA, et al. Association of ADAM33 with asthma and associated phenotypes in ethically diverse populations. Am J Hum Gen 2002;71:488.
15. Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet 2000;16:83-7.
16. Black RA, White JM. ADAMs: focus on the protease domain. Curr Opin Cell Biol 1998;10:654-9.
17. Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene 2002;282:227-36.
18. De Sanctis GT, Merchant M, Beier DR, et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nature Genet 1995;11:150-4.
19. Gunn TM, Azarani A, Kim PH, et al. Identification and preliminary characterization of mouse Adam33. BMC Genet 2002;3:2.
20. Holgate ST, Davies DE, Lackie PM, et al. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000;105:193-204.
21. Richter A, Puddicombe SM, Lordan JL, et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial- mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 2001;25:385-91.
22. Davies DE, Wicks J, Powell RM, et al. Airway remodelling in asthma: new insights. J Allergy Clin Immunol 2003;111:215-22. (epub ahead of publication).
23. Zhang S, Smartt H, Holgate ST, et al. Growth factors secreted by bronchial epithelial cells control myofibrobbst proliferation: an in vitro co-culture model of airway remodeling in asthma. Lab Invest 1999;79:395-405.
24. Puddicombe SM, Polosa R, Richter A, et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000;14:1362-74.
25. Chaudhary N, Richter A, Collins JE, et al. Phenotype comparison of asthmatic and nonasthmatic (Myo)fibroblasts. Am J Respir Crit Care Med 2001;163:A473
26. Johnson PR, Roth M, Tamm M, et al. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001;164:474-7.
27. Izumi Y, Hirata M, Hasuwa H, et al. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 1998;17:7260-72.
28. Nath D, Slocombe PM, Webster A, et al. Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1)integrin, leading to a marked induction of fibroblast cell motility. J Cell Sci 2000;113:2319-28.
29. Gilpin BJ, Loechel F, Mattei MG, et al. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J Biol Chem 1998;273:157-66.
30. Levy GG, Nichols WC, Lian EC, et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 2001;413:488-94.
31. Colige A, Sieron AL, Li SW, et al. Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. Am J Hum Genet 1999;65:308-17.
32. Howard L, Nelson KK, Maciewicz RA, et al. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J Biol Chem 1999;274:31693-9.
33. Galliano MF, Huet C, Frygelius J, et al. Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion. J Biol Chem 2000;275:13933-9.
34. Cousin H, Gaultier A, Bleux C, et al. PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. Dev Biol 2000;227:197-210.
35. Poghosyan Z, Robbins SM, Houslay MD, et al. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein tyrosine kinases. J Biol Chem 2002;277:4999-5007.
36. Hougaard S, Loechel F, Xu X, et al. Trafficking of human ADAM 12-L: retention in the trans-Golgi network. Biochem Biophys Res Commun 2000;275:261-7.
37. Drazen JM, Weiss ST. Genetics: inherit the wheeze. Nature 2002;418:383-4.
38. Shapiro SD, Owen CA. ADAM-33 surfaces as an asthma gene. N Engl J Med 2002;347:936-8.
39. Peschon JJ, Slack JL, Reddy P, et al. An essential role for ectodomain shedding in mammalian development. Science 1998;282:1281-4.
40. Asakura M, Kitakaze M, Takashima S, et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nature Med 2002;8:35-40.
41. Huet C, Li ZF, Liu HZ, et al. Skeletal muscle cell hypertrophy induced by inhibitors of metalloproteases; myostatin as a potential mediator. Am J Physiol Cell Physiol 2001;281:C1624-34.
42. Nath D, Slocombe PM, Stephens PE, et al. Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. J Cell Sci 1999;112:579-87.
43. Iba K, Albrechtsen R, Gilpin B, et al. The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading. J Cell Biol 2000;149:1143-56.
44. Chen MS, Tung KS, Coonrod SA, et al. Role of the integrin-associated protein CD9 in binding between sperm. ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization. Proc Natl Acad Sci USA 1999;96:11830-5.
45. Herren B, Garton KJ, Coats S, et al. ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions. Exp Cell Res 2001;271:152-60.
46. Hirst SJ. Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma. Eur Respir J 1996;9:808-20.
47. Ahmadi KR, Goldstein DB. Multifactorial diseases: asthma genetics point the way. Curr Biol 2002;12:R702-4.
48. Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nature Genet 2000;26:163-75.
49. Hampe J, Grebe J, Nikolaus S, et al. Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study. Lancet 2002;359:1661-5.