Differential gene expression underlying the functional distinctions of primary human CD34+ hematopoietic stem and progenitor cells from peripheral blood and bone marrow

Annals of the New York Academy of Sciences

Volumn 996, Issue , 2003, Pages 89-100

  Steidl, Ulrich ^a   Kronenwett, Ralf ^a   Haas, Rainer ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cell cycle; DNA replication; Gene expression profiling; Genetics; Hematopoietic stem cells; Migration; Transcription factors

Indexed keywords

CD34 ANTIGEN; COMPLEMENTARY DNA; GRANULOCYTE COLONY STIMULATING FACTOR; THROMBIN RECEPTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ALLOGENIC BONE MARROW TRANSPLANTATION; APOPTOSIS; BLOOD CELL; BONE MARROW CELL; CANCER CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL MIGRATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

EID: 0037791985     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb03237.x     Document Type: Conference Paper

References (49)

1. HAAS, R., B. WITT, R. MOHLE, et al. 1995. Sustained long-term hematopoiesis after myeloablative therapy with peripheral blood progenitor cell support. Blood 85: 3754-3761
2. KOBBE, G., U. GERMING, M. AIVADO, et al. 2002. Treatment of secondary myelodysplastic syndrome (MDS) after heart transplantation with chemotherapy and non-myeloablative stem cell transplantation. Transplantation 74: 1198-1200.
3. KOBBE, G., P. SCHNEIDER, M. AIVADO, et al. 2002. Reliable engraftment, low toxicity and durable remissions following allogeneic blood stem cell transplantations with minimal conditioning. Exp. Hematol. 30: 1346-1353.
4. KRONENWETT, R., S. MARTIN & R. HAAS. 2000. The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells. Stem Cells 18: 320-330.
5. HOHAUS, S., H. GOLDSCHMIDT, R. EHRHARDT, et al. 1993. Successful autografting following myeloablative conditioning therapy with blood stem cells mobilized by chemotherapy plus rhG-CSF. Exp. Hematol. 21: 508-514.
6. LICHTERFELD, M., S. MARTIN, L. BURKLY, et al. 2000. Mobilization of CD34+ haematopoietic stem cells is associated with a functional inactivation of the integrin very late antigen 4. Br. J. Haematol. 110: 71-81.
7. STEIDL, U., R. KRONENWETT, S. MARTIN & R. HAAS. 2003. Molecular biology of hematopoietic stem cells. Vitam. Horm. 66: 1-28.
8. ORLIC, D., J. KAJSTURA, S. CHIMENTI, et al. 2001. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. USA 98: 10344-10349.
9. LAGASSE, E., H. CONNORS, M. AL-DHALIMY, et al. 2000. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6: 1229-1234.
10. MEZEY, E., K.J. CHANDROSS, G. HARTA, et al. 2000. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290: 1779-1782.
11. STEIDL, U., R. KRONENWETT, U.P. ROHR, et al. 2002. Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow-derived and circulating human CD34+ hematopoietic stem cells. Blood 99: 2037-2044.
12. STEIDL, U., R. HAAS & R. KRONENWETT. 2000. Intercellular adhesion molecular 1 on monocytes mediates adhesion as well as trans-endothelial migration and can be downregulated using antisense oligonucleotides. Ann. Hematol. 79: 414-423.
13. KRONENWETT, R., U. STEIDL, M. KIRSCH, et al. 1998. Oligodeoxyribonucleotide uptake in primary human hematopoietic cells is enhanced by cationic lipids and depends on the hematopoietic cell subset. Blood 91: 852-862.
14. BEISSBARTH, T., K. FELLENBERG, B. BRORS, et al. 2000. Processing and quality control of DNA array hybridization data. Bioinformatics 16: 1014-1022.
15. KRONENWETT, R., T. GRAF, W. NEDBAL, et al. 2002. Inhibition of angiogenesis in vitro by alphav integrin-directed antisense oligonucleotides. Cancer Gene Ther. 9: 587-596.
16. ROHR, U.P., M.A. WULFF, S. STAHN, et al. 2002. Fast and reliable titration of recombinant adeno-associated virus type-2 using quantitative real-time PCR. J. Virol. Methods 106: 81-88.
17. MESSNER., H.A. 1991. Human hemopoietic progenitors and their signals. Bone Marrow Transplant. 7 (Suppl 1): 18-22.
18. DUHRSEN, U., J.L. VILLEVAL, J. BOYD, et al. 1988. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72: 2074-2081.
19. SAHA, P., Q. EICHBAUM, E.D. SILBERMAN, et al. 1997. p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Mol. Cell Biol. 17: 4338-4345.
20. SAVILLE, M.K. & R.J. WATSON. 1998. B-Myb: a key regulator of the cell cycle. Adv. Cancer Res. 72: 109-140.
21. RASCHELLA, G., B. TANNO, F. BONETTO, et al. 1997. Retinoblastoma-related protein pRb2/p130 and its binding to the B-myb promoter increase during human neuroblastoma differentiation. J. Cell. Biochem. 67: 297-303.
22. KALLIO, M., J. WEINSTEIN, J.R. DAUM, et al. 1998. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141: 1393-1406.
23. TOWNSLEY, F.M., A. ARISTARKHOV, S. BECK, et al. 1997. Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc. Natl. Acad. Sci. USA 94: 2362-2367.
24. TOMKINSON, A.E. & Z.B. MACKEY. 1998. Structure and function of mammalian DNA ligases. Mutat. Res. 407: 1-9.
25. CHONG, J.P., P. THOMMES & J.J. BLOW. 1996. The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci. 21: 102-106.
26. OHTANI, K., R. IWANAGA, M. NAKAMURA, et al. 1999. Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene 18: 2299-2309.
27. UCHIDA, N., D. HE, A.M. FRIERA, et al. 1997. The unexpected G0/G1 cell cycle status of mobilized hematopoietic stem cells from peripheral blood. Blood 89: 465-472.
28. RUMI, C., S. RUTELLA, L. TEOFILI, et al. 1997. RhG-CSF-mobilized CD34+ peripheral blood progenitors are myeloperoxidase-negative and noncycling irrespective of CD33 or CD13 coexpression. Exp. Hematol. 25: 246-251.
29. JIANG, C., Z. WANG, H. GANTHER, et al. 2001. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res. 61: 3062-3070.
30. NAKAMURA, H., T. ODA, K. HAMADA, et al. 1998. Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. J. Biol. Chem. 273: 15345-15351.
31. FRISCH, S.M. & E. RUOSLAHTI. 1997. Integrins and anoikis. Curr. Opin. Cell Biol. 9: 701-706.
32. BRIEGEL, K., K.C. LIM, C. PLANK, et al. 1993. Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes Dev. 7: 1097-1109.
33. KUMANO, K., S. CHIBA, K. SHIMIZU, et al. 2001. Notchl inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. Blood 98: 3283-3289.
34. STANTON, B.R. & L.F. PARADA. 1992. The N-myc proto-oncogene: developmental expression and in vivo site-directed mutagenesis. Brain Pathol. 2: 71-83.
35. HAAS, R., R. MOHLE, M. PFORSICH, et al. 1995. Blood-derived autografts collected during granulocyte colony-stimulating factor-enhanced recovery are enriched with early Thy-1+ hematopoietic progenitor cells. Blood 85: 1936-1943.
36. MURRAY, L.J., A. TSUKAMOTO & R. HOFFMAN. 1996. CD34+Thy-1+Lin- stem cells from mobilized peripheral blood. Leuk. Lymphoma 22: 37-42.
37. HUMEAU, L., F. BARDIN, C. MAROC, et al. 1996. Phenotypic, molecular, and functional characterization of human peripheral blood CD34+/THY1+ cells. Blood 87: 949-955.
38. DONAHUE, R.E., M.R. KIRBY, M.E. METZGER, et al. 1996. Peripheral blood CD34+ cells differ from bone marrow CD34+ cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte colony-stimulating factor and/or stem cell factor. Blood 87: 1644-1653.
39. MOHLE, R., S. MUREA, M. KIRSCH, et al. 1995. Differential expression of L-selectin, VLA-4, and LFA-1 on CD34+ progenitor cells from bone marrow and peripheral blood during G-CSF-enhanced recovery. Exp. Hematol. 23: 1535-1542.
40. DEGUCHI, T. & Y. KOMADA. 2000. Homing-associated cell adhesion molecule (H-CAM/CD44) on human CD34+ hematopoietic progenitor cells. Leuk. Lymphoma 40: 25-37.
41. VOERMANS, C., P.M. ROOD, P.L. HORDIJK, et al. 2000. Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells. Stem Cells 18: 435-443.
42. MOHLE, R., F. BAUTZ, S. RAFII, et al. 1998. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 91: 4523-4530.
43. DEICHMANN, M., R. KRONENWETT & R. HAAS. 1997. Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells. Blood 89: 3522-3528.
44. EVEN-RAM, S., B. UZIELY, P. COHEN, et al. 1998. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat. Med. 4: 909-914.
45. EVEN-RAM, S.C., M. MAOZ, E. POKROY, et al. 2001. Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin. J. Biol. Chem. 276: 10952-10962.
46. STOUFFER, G.A. & M.S. RUNGE. 1998. The role of secondary growth factor production in thrombin-induced proliferation of vascular smooth muscle cells. Semin. Thromb. Hemost. 24: 145-150.
47. DERY, O., C.U. CORVERA, M. STEINHOFF, et al. 1998. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 274: C1429-C1452.
48. JENNE, D.E. 1994. Structure of the azurocidin, proteinase 3, and neutrophil elastase genes. Implications for inflammation and vasculitis. Am. J. Respir. Crit. Care Med. 150: S147-S154.
49. SUGIMORI, T., J. COOLEY, J.R. HOIDAL, et al. 1995. Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor. Am. J. Respir. Cell. Mol. Biol. 13: 314-322.