Reliable engraftment, low toxicity, and durable remissions following allogeneic blood stem cell transplantation with minimal conditioning

Experimental Hematology

Volumn 30, Issue 11, 2002, Pages 1346-1353

  Kobbe, Guido ^a   Schneider, Peter ^a   Aivado, Manuel ^a   Zohren, Fabian ^a   Schubert, Dominique ^a   Fenk, Roland ^a   Neumann, Frank ^a   Kronenwett, Ralf ^a   Pape, Hildegard ^a   Rong, Astrid ^a   Royer Pokora, Brigitte ^b   Hildebrandt, Barbara ^b   Germing, Ulrich ^a   Gattermann, Norbert ^a   Heyll, Axel ^a   Haas, Rainer ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; BASILIXIMAB; CALCINEURIN INHIBITOR; CYCLOSPORIN; FAMCICLOVIR; FLUDARABINE; GANCICLOVIR; GEMCITABINE; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RITUXIMAB; STEROID; SULFAMETHOXAZOLE; THYMOCYTE ANTIBODY; TRIMETHOPRIM; TSUKUBAENOLIDE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER; CANCER ADJUVANT THERAPY; CANCER REGRESSION; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; CYTOPENIA; DISEASE COURSE; FEMALE; FOLLOW UP; GRAFT VERSUS HOST REACTION; HIGH RISK POPULATION; HUMAN; HUMAN CELL; LYMPHOMA; MALE; MYELOFIBROSIS; MYELOMA; NEPHROTOXICITY; PNEUMOCYSTOSIS; PRIORITY JOURNAL; RADIATION CHIMERA; RADIATION INDUCED EMESIS; RADIATION PNEUMONIA; RADIATION SICKNESS; RELIABILITY; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEASIBILITY STUDIES; FEMALE; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; GRAFT VS LEUKEMIA EFFECT; GRAFT VS TUMOR EFFECT; HEMATOLOGIC NEOPLASMS; HUMAN; LEUKEMIA, MYELOID; LYMPHOMA; MALE; MIDDLE AGE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROMES; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; REMISSION INDUCTION; RISK; SALVAGE THERAPY; SUPPORT, NON-U.S. GOV'T; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; WHOLE-BODY IRRADIATION;

EID: 0036840029     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(02)00923-2     Document Type: Article

References (29)

1. Thomas E.D., Storb R., Clift R.A.et al. Bone-marrow transplantation. N Engl J Med. 292:1975;832.
2. Barnes D.W.H., Corp M.J., Loutit J.F.et al. Treatment of murine leukemia with x rays and homologous bone marrow. preleminary communication Br Med J. 2:1956;626.
3. Weiden P.L., Flournoy N., Thomas E.D.et al. Antileukemic effect of graft-vs-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med. 300:1979;1068.
4. Weiden P.L., Sullivan K.M., Flournoy N.et al. Antileukemic effect of chronic graft-vs-host disease. Contribution to improved survival after allogeneic marrow transplantation. N Engl J Med. 304:1981;1529.
5. Horowitz M.M., Gale R.P., Sondel P.M.et al. Graft-vs-leukemia reactions after bone marrow transplantation. Blood. 75:1990;555.
6. Kolb H.J., Mittermüller J., Clemm C.H.et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood. 76:1990;2462.
7. Kolb H.J., Schattenberg A., Goldman J.M.et al. Graft-vs-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party. Blood. 86:1995;2041.
8. Collins R.H. Jr., Shpilberg O., Drobyski W.R.et al. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol. 15:1997;433.
9. Marmont A.M., Horowitz M.M., Gale R.P.et al. T-cell depletion of HLA-identical transplants in leukemia. Blood. 78:1991;2120.
10. Slavin S., Nagler A., Naparstek E.et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood. 91:1998;756.
11. Storb R., Yu C., Wagner J.L.et al. Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total-body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood. 89:1997;3048.
12. Georges G.E., Storb R., Thompson J.D.et al. Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation. Blood. 95:2000;3262.
13. McSweeney P.A., Niederwieser D., Shizuru J.A.et al. Hematopoietic cell transplantation in older patients with hematologic malignancies. replacing high-dose cytotoxic therapy with graft-vs-tumor effects Blood. 97:2001;3390.
14. Giralt S., Estey E., Albitar M.et al. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy. harnessing graft-vs-leukemia without myeloablative therapy Blood. 89:1997;4531.
15. Khouri I.F., Keating M., Körbling M.et al. Transplant-lite. induction of graft-vs-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies J Clin Oncol. 16:1998;2817.
16. Carella A.M., Cavaliere M., Lerma E.et al. Autografting followed by nonmyeloablative immunosuppressive chemotherapy and allogeneic peripheral-blood hematopoietic stem-cell transplantation as treatment of resistant Hodgkin's disease and non-Hodgkin's lymphoma. J Clin Oncol. 18:2000;3918.
17. Michallet M., Bilger K., Garban F.et al. Allogeneic hematopoietic stem cell transplantation after nonmyeloablative preparative regimens. impact of pretransplantation and posttransplantation factors on outcome J Clin Ocol. 19:2001;3340.
18. nd ed:1999;Blackwell Science, Boston. 197p.
19. Kobbe G., Schneider P., Rohr U.et al. Treatment of severe steroid refractory acute graft vs host disease with infliximab, a chimeric human/mouse antiTNFα antibody. Bone Marrow Transplant. 28:2001;47.
20. Carella A.M., Champlin R., Slavin S.et al. Mini-allografts. ongoing trials in humans Bone Marrow Transplant. 25:2000;345. [editorial].
21. McSweeney P.A., Storb R. Mixed chimerism. preclinical studies and clinical applications Biol Blood Marrow Transplant. 5:1999;192. [review].
22. Childs R., Chernoff A., Contentin N.et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med. 343:2000;750.
23. Childs R., Clave E., Contentin N.et al. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation. full donor T-cell chimerism precedes alloimmune responses Blood. 94:2000;3234.
24. Mattson J., Uzunel M., Brune M.et al. Mixed chimaerism is common at the time of acute graft-vs-host disease and disease response in patients receiving nonmyeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol. 115:2001;935.
25. Badros A., Barlogie B., Morris C.et al. High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions. Blood. 97:2000;2574.
26. Ferrant A., Labopin M., Frassoni F.et al. Karyotype in acute myeloblastic leukemia. prognostic significance for bone marrow transplantation in first remission: a European group for blood and marrow transplantation study Blood. 90:1997;2931.
27. Runde V., De Witte T., Brand R.et al. Chromosomal characteristics are an independent risk factor for relapse after HLA-identical sibling transplantation in patients with myelodysplastic syndromes (MDS) or secondary acute myeloid leukemia. Blood. 96(suppl 1):2000;523a. [abstract #2250].
28. Hegenbart U., Lange T., Pönisch W.et al. Allogeneic hematopoietic stem cell transplantation from related and unrelated donors in patients with AML treated with 2 Gy total-body irradiation and posttransplant immunosuppression with cyclosporine and mycophenolate mofetile. Bone Marrow Transplant. 27(suppl 1):2001;2-83. [abstract #P780].
29. Nieto Y., Bearman S.I., Shpall E.J.et al. Intensive chemotherapy for progressive chronic lymphocytic leukemia administered early after a nonmyeloablative allograft. Bone Marrow Transplant. 11:2001;1083.