Synthesis of 99mTc(CO)3-mebrofenin via [99mTc(OH2)3(CO)3]+ precursor and comparative pharmacokinetics studies with 99mTc-mebrofenin

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 46, Issue 7, 2003, Pages 633-644

  Kothari, Kanchan ^a   Joshi, Sangeeta ^a   Venkatesh, Meera ^a   Ramamoorthy, N ^a   Pillai, M R A ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

99mTc carbonyl; 99mTc iminodiacetic acid; Hepatobiliary agents; Mebrofenin; Technetium 99m

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORGANOMETALLICS; TECHNETIUM;

99MTC-CARBONYL; 99MTC-IMINODIACETIC ACID; HEPATOBILIARY; HEPATOBILIARY AGENT; IMINODIACETIC ACID; MEBROFENIN; ORGANOMETALLIC PRECURSORS; PHARMACOKINETIC STUDIES; TECHNETIUM-99M; [CARBONYL;

AMINO ACIDS;

CARBONYLMEBROFENIN; CARBONYLMEBROFENIN TC 99M; CYSTEINE; HISTIDINE; MEBROFENIN; MEBROFENIN TC 99M; PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; COMPARATIVE STUDY; COMPLEX FORMATION; DECOMPOSITION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOUSE; NONHUMAN; PH MEASUREMENT; REACTION ANALYSIS;

EID: 0037787764     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.704     Document Type: Article

References (24)

1. Salmain M, Gunn M, Gorfi A, Top S, Jaouen G. Bioconjugate Chem 1993; 4: 425-433.
2. Top S, Hafa EH, Vessieres A, et al. J Am Chem Soc 1995; 117: 8372-8380.
3. Alberto R, Schibli R, Egli A, Schubiger AP, J Am Chem Soc 1998; 120: 7987-7988.
4. Resigys M, Wust F, Alberto R, et al. Bioorg Med Chem Lett 1998; 17: 2243-2246.
5. Alberto R, Schibli R, Schubiger PA, Abram U, Pietzsch HJ, Johannsen B. J Am Chem Soc 1999; 121: 6076-6077.
6. Schibli R, Bella RL, Alberto R, et al. Bioconjugate Chem 2000; 11: 345-351.
7. Pietzsch HJ, Gupta A, Reisgys M, et al. Bioconjugate Chem 2000; 11: 414-424.
8. Egli A, Alberto R, Tannahill L, et al. J Nucl Med 1999; 40: 1913-1917.
9. Waibel R, Alberto R, Willuda J, et al. Nat Biotechnol 1999; 17: 897-901.
10. Kothari KK, Pillarsetty NK, Katti KV, Volkert WA. Radiochim Acta, 2003; 91: 53-57.
11. Schibli R, Katti KV, Higginbotham C, Volkert WA, Alberto R, Nucl Med Biol 1999; 26: 711-716.
12. Alberto R, Wald J, Ortner K, Candreia L, Pietzsch HJ. J Label Compd Radiopharm, 2001; 44: S54-S56.
13. Pietzsch HJ, Gupta A, Reisgys M, et al. Bioconjugate Chem 2000; 11: 414-424.
14. Dumas C, Petrig J, Schibli R, Stabel J, Scapozza L, Mertens J. J Label Compd Radiopharm, 2001; 44: S57-S59.
15. Du J, Hiltunen J, Marquez M, Nilsson S, AR Holmberg, Technetium -99m labelling of glycosylated somatostatin-14, Appl Radiat Isot 2001; 55: 181-187.
16. Blauenstein P, Garcia Garayoa E, Blanc A, et al. J Label Compd Radiopharm, 2001; 44: S556-S558.
17. Schibli R, Blanc A, Garcia-Garayoa E, Blauenstein P, Schubiger PA, Tourrwe D. J Label Compd Radiopharm, 2001; 44: S501-S503.
18. Jiang D, Jia F, Liu BL, Wang XY. J Label Compd Radiopharm, 2001; 44: S585-S587.
19. Ben-Haim S, Seabold JE, Kao SS, Johnson J, Tran D, Brown BP. Clin Nucl Med 1995; 20:153-163.
20. Ziessman HA, Fahey FH, Hixson DJ. J Nucl Med 1992; 33: 537-544, 1992.
21. Nunn AD, Loberg MD, Conley RA. J Nucl Med 1983, 24: 423-430.
22. Loberg MD, Cooper M, Harvey E, Callery P, Faith W, J Nucl Med 1976; 17: 633-638.
23. Loberg MD, Fields AT. Int J Appl Radiat Isot 1978; 29: 167-173.
24. Kothari K, Banerjee S, Sarma HD, Pillai MRA, Appl Radiat Isot 2000; 52: 69-76.