Syntheses and radiolabeling of cysteine-oximes and pharmacological behaviour of their 99mTc complexes

Applied Radiation and Isotopes

Volumn 52, Issue 1, 2000, Pages 69-76

  Kothari, Kanchan ^a   Banerjee, Sharmila ^a   Sarma, H D ^a   Pillai, M R A ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

99mTc complexes; Cysteine oxime; Cysteine oxime ester; Novel ligands

Indexed keywords

COMPLEXATION; ELECTROPHORESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH EFFECTS; RADIOISOTOPES; SYNTHESIS (CHEMICAL); TECHNETIUM; THIN LAYER CHROMATOGRAPHY;

CYSTEINE OXIME ESTER; LIGANDS; LIPOPHILICITY; RADIOLABELING; SCHIFF'S BASE;

AMINO ACIDS;

CYSTEINE PROTEINASE; OXIME; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; ISOTOPE LABELING; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; PRIORITY JOURNAL; REDUCTION; TISSUE DISTRIBUTION;

ANIMALS; CYSTEINE; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; ORGANOTECHNETIUM COMPOUNDS; OXIMES; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 0033992404     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(99)00121-9     Document Type: Article

References (11)

1. 99mTc-tetramethyl- and pentamethyl propylene amineoxime chelates. Nucl. Med. Biol. 13:1986;261-267.
2. 99mTc-HM-PAO). Nucl. Med. Commun. 6:1985;443-447.
3. Johannsen B., Syhre R., Spies H., Munze R. Chemical and biological characterisation of different Tc complexes of cysteine and cysteine derivatives. J. Nucl. Med. 19:1978;816-824.
4. 99Mo for research in Technetium chemistry. International Symposium on Radiochemistry and Radiation, Bombay. AR-19, 1-2.
5. 99mTc complexes. J. Nucl. Med. 25:1984;326-332.
6. Leveille J., Demonceau G., Roo M.D., Rigo P., Taillefer R., Morgan R.A., Kupranick D., Walovitch R.C. Characterization of technetium-99m-L-L-ECD for brain perfusion imaging. Part 2. Biodistribution and brain imaging in humans. J. Nucl. Med. 30:1989;1902-1910.
7. Neirinckx R.D., Canning L.R., Piper I.M., Nowotnik D.P., Pickett R.D., Holmes R.A., Volkert W.A., Forster A.M., Weisner P.S., Marriott J.A., Chaplin S.B. A new radiopharmaceutical for Spect imaging of regional cerebral blood perfusion. J. Nucl. Med. 28:1987;191-192.
8. 99mTc-labelled radiopharmaceutical for cerebral blood flow imaging. Nucl. Med. Commun. 6:1985;499-506.
9. 99mTc. International Symposium on Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy Proceedings, IAEA TECDOC-1029. 1998;157-176.
10. Sharp P.F., Smith F.W., Gemmell H.G., Lyall D., Evans N.T.S., Gvozdanovic E.D., Davidson J., Tyrell D.A., Pickett R.D., Neirinckx R.D. Technetium-99m HMPAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies. J. Nucl. Med. 27:1986;171-177.
11. Vallabhajosula S., Zimmerman R.E., Picard M., Stritzke P., Mena I., Hellman R.S., Tikofsky R.S., Stabin M.G., Morgan R.A., Goldsmith S.J. Technetium-99m ECD a new brain imaging agent. In vivo kinetics and biodistribution studies in normal human subjects. J. Nucl. Med. 30:1989;599-604.