Cysteine proteinases and cystatin C in bronchoalveolar lavage fluid from subjects with subclinical emphysema

European Respiratory Journal

Volumn 12, Issue 5, 1998, Pages 1033-1039

  Takeyabu, K ^a,b   Betsuyaku, T ^a   Nishimura, M ^a   Yoshioka, A ^a   Tanino, M ^a   Miyamoto, K ^a   Kawakami, Y ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Sapporo Medical University   (Japan)

Author keywords

Alveolar macrophages; Bronchoalveolar lavage; Cathepsin L; Cystatin C; Neutrophil elastase; Pulmonary emphysema

Indexed keywords

ALPHA 1 ANTITRYPSIN; CATHEPSIN B; CATHEPSIN L; CYSTATIN C; CYSTEINE PROTEINASE; LEUKOCYTE ELASTASE;

ADULT; AGED; AGING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; LUNG ALVEOLUS MACROPHAGE; LUNG EMPHYSEMA; LUNG LAVAGE; PRIORITY JOURNAL; SMOKING;

EID: 0031760367     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12051033     Document Type: Article

References (30)

1. Snider GL. Emphysema: the first two centuries - and beyond. A historical overview, with suggestions for future research. Part 2. Am Rev Respir Dis 1992; 146: 1615-1622.
2. Tetley TD. New perspectives on basic mechanisms in lung disease. 6. Proteinase imbalance: its role in lung disease. Thorax 1993; 48: 560-565.
3. 1proteinase inhibitor complex in bronchoalveolar lavage fluids from healthy human subjects. Am Rev Respir Dis 1985; 132: 913-914.
4. Janoff A, Raju L, Dearing R. Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers. Am Rev Respir Dis 1983; 127: 540-544.
5. Fujita L, Nelson NL, Daughton DM, et at. Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema. Am Rev Respir Dis 1990; 142: 57-62.
6. Yoshioka A, Betsuyaku T, Nishimura M, Miyamoto K, Kondo T, Kawakami Y. Excessive neutrophil elastase in bronchoalveolar lavage fluid in subclinical emphysema. Am J Respir Crit Care Med 1995; 152: 2127-2132.
7. Betsuyaku T, Yoshioka A, Nishimura M, Miyamoto K, Kawakami Y. Neutrophil elastase associated with alveolar macrophages from older volunteers. Am J Respir Crit Care Med 1994; 151: 436-442.
8. Finlay GA, Russel KJ, McMahon KJ, et al. Elevated levels of matrix metalloproteinases in bronchoal veolar lavage fluid of emphysematous patients. Thorax 1997; 52: 502-506.
9. Chapman HA Jr, Munger JS, Shi GP. The role of thiol proteases in lung tissue injury and remodeling. Am J Respir Crit Care Med 1994; 150: S155-159.
10. Mason RW, Johnson DA, Barrett AJ, Chapman HA. Elastinolytic activity of human cathepsin L. Biochem J 1986; 233: 925-927.
11. Johnson DA, Barrett AJ, Mason RW. Cathepsin L inactivates α-proteinase inhibitor by cleavage in the reactive site region. J Biol Chem 1986; 261: 14748-14751.
12. Takahashi H, Ishidoh K, Muno D, et al. Cathepsin L activity is increased in alveolar macrophages and bronchoal-veolar lavage fluid of smokers. Am Rev Respir Dis 1993; 147: 1562-1568.
13. Chapman HA Jr, Reilly JJ, Yee R, Grubb A. Identification of cystatin C, a cysteine proteinase inhibitor, as a major secretory product of human alveolar macrophages in vitro. Am Rev Respir Dis 1990; 141: 698-705.
14. Betsuyaku T, Yoshioka A, Nishimura M, Miyamoto K, Kawakami Y. Pulmonary function is diminished in older asymptomatic smokers and ex-smokers with low attenuation areas on high-resolution computed tomography. Respiration 1996; 63: 333-338.
15. Jarvis MJ. Comparison of tests used to distinguish smokers from nonsmokers. Am J Public Health 1987; 77: 1435-1438.
16. Rennard SI, Ghafouri M,Thompson AB, et al. Fractional processing of sequential bronchoalveolar lavage to separate bronchial and alveolar samples. Am Rev Respir Dis 1990; 141: 208-217.
17. Bagchi D, Hassoun EA, Bagchi M, Stohs SJ. Protective effects of free radical scavengers and antioxidants against smokeless tobacco extract (STE)-induced oxidative stress in macrophage J774A.1. Arch Environ Contam Taxicol 1995; 29: 424-428.
18. Barrett AJ, Kirschke H. Cathepsin B, cathepsin H, cathepsin L. Meth Enzymol 1981; 80: 535-561.
19. Murata M, Miyashita S, Yokoo C, et al. Novel epoxysuccinyl peptides: selective inhibitors of cathepsin B, in vitro. FEBS Lett 1991; 280: 307-310.
20. Snider GL, Ciccolella DE, Morris SM, Stone PJ, Lucey EC. Putative role of neutrophil elastase in the pathogenesis of emphysema. Ann NY Acad Sci 1991; 624: 45-59.
21. BAL Cooperative Group Steering Committee. Bronchoalveolar lavage constituents in healthy individuals, idiopathic pulmonary fibrosis, and selected comparison groups. Am Rev Respir Dis 1990; 141: S169-S202.
22. Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974; 291: 755-758.
23. Finkelstein R, Fraser RS, Ghezzo H, Cosio MG. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med 1995; 152: 1666-1672.
24. Reilly JJ, Mason RW, Chen P, et al. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages. Biochem J 1989; 257: 493-498.
25. Kominami E, Tsukahara T, Hara K, Katunuma N. Biosynthesis and processing of lysosomal cysteine proteinases in rat macrophages. FEBS Lett 1988; 231: 225-228.
26. Baron R, Neff L, Louvard D, Courtoy PJ. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 1985; 101: 2210-2222.
27. Kao RC, Wehmer NG, Skubitz KM, Gray BH, Hoidal JR. Proteinase 3: a distinct human polymorphonuclear leukoeyte proteinase that produces emphysema in hamsters. J Clin Invest 1988; 82: 1963-1973.
28. Lesser M, Padilla ML, Cardozo C, Induction of emphysema in hamsters by intratracheal instillation of cathepsin B. Am Rev Respir Dis 1992; 145: 661-668.
29. Reilly JL, Chen P, Sailor LZ, Wilcox D, Mason RW, Chapman HA. Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L. Am J Physiol 1991; 261: L41-L48.
30. Warfel AH, Cardozo C, Zucker OH, Franklin DJ. Cystatin C and cathepsin B production by alveolar macrophages from smokers and nonsmokers. J Lenkoc Biol 1991; 49: 41-47.