Cutting edge: Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4143-4147

  Huang, Fang Ping ^a,b   Xu, Damo ^a   Esfandiari, Ehsan O ^a   Sands, William ^a,c   Wei, Xiao Qing ^a   Liew, Foo Y ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; GENE MUTATION; HELPER CELL; INFECTION RESISTANCE; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPHOID CELL; MOUSE; MUTANT; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MOUSE MUTANT; MUTATION; SKIN LEISHMANIASIS; TH1 CELL;

ANIMALS; ANTIGENS, CD95; GENETIC PREDISPOSITION TO DISEASE; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, MUTANT STRAINS; MUTATION; NITRIC OXIDE; TH1 CELLS;

EID: 0032063360     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
2. Watson, M. L., J. K. Rao, G. K. Gilkeson, P. Ruiz, E. M. Eicher, D. M. Pisetsky, A. Matsuzawa, J. M. Rochelle, and M. F. Seldin. 1992. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease modifying loci. J. Exp. Med. 176:1645.
3. Cohen, P. L., and R. A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol 9:243.
4. Andrew, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
5. Huang, F.-P., G.-J. Feng, G. Lindop, D. I. Stott, and F. Y. Liew. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL-lpr/lpr mice. J. Exp. Med. 183:1447.
6. Sypek, J. P., C. L. Chung, S. E. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
7. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
8. Wei, X.-q., I. G. Charles, A. Smith, G. Ure, G.-j. Feng, F.-p. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:411.
9. Liew, F. Y., and C. A. O'Donnell. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32:161.
10. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
11. Trinchieri G., and P. Scott. 1994. The role of IL-12 in the immune response, disease and therapy. Immunol. Today 15:460.
12. h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur. J. Immunol. 21:3009.
13. Bogdan, C., Y. Vodovotz, J. Paik, Q.-w. Xie, and C. Nathan. 1994. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J. Leukoc. Biol. 55:227.
14. Howard, J. G., C. Hale, and F. Y. Liew. 1980. Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. J. Exp. Med. 152:594.
15. McSorley, S. J., D. Xu, and F. Y. Liew. 1997. Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters. Infect. Immun. 65: 171.
16. Moshage, H. J., B. Kok, J. R. Huizenga, and P. L. M. Jansen. 1995. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin. Chem. 41:892.
17. 15N] nitrate in biological fluids. Anal. Biochem. 126:131.
18. Proudfoot, L., A. V. Nikolaev, G.-j. Feng, X.-q. Wei, M. A. J. Ferguson, J. S. Brimacombe, and F. Y. Liew. 1996. Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc. Natl. Acad. Sci. USA 93:10984.
19. Nagata, S. 1994. Fas and Fas ligand: a death factor and its receptor. Adv. Immunol. 57:129.
20. + T cell-mediated cytotoxicity. J. Immunol. 152:1127.
21. h2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6:1545.
22. + cytotoxic T cells. Proc. Natl. Acad. Sci. USA 91:4185.
23. h1 cell development. Science 271:984.
24. Sarih, U., V. Souvannavong, and A. Adam. 1993. Nitric oxide synthase induces macrophage death by apoptosis. Biochem. Biophys. Res. Commun. 191:503.
25. Cory, S. 1995. Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13:513.