Leishmania pifanoi pathogenesis: Selective lack of a local cutaneous response in the absence of circulating antibody

Infection and Immunity

Volumn 70, Issue 12, 2002, Pages 6597-6605

  Colmenares, María ^a   Constant, Stephanie L ^a,b   Kima, Peter E ^a,c   McMahon Pratt, Diane ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYTOKINE; FC RECEPTOR;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOST PARASITE INTERACTION; IMMUNE RESPONSE; LEISHMANIA; LEISHMANIA DONOVANI; LEISHMANIA MEXICANA; LEISHMANIA PIFANOI; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; SKIN MANIFESTATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; EAR; LEISHMANIA; LEISHMANIASIS, CUTANEOUS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; SKIN;

EID: 0036893685     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.12.6597-6605.2002     Document Type: Article

References (43)

1. Afonso, L. C., and P. Scott. 1993. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect. Immun. 61:2952-2959.
2. Alonso, A., Y. Bayon, M. Renedo, and M. S. Crespo. 2000. Stimulation of Fc gamma R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I kappa B-alpha degradation and formation of p50/p65 NF-kappa B/Rel complexes. Int. Immunol. 12:547-554.
3. Balestieri, F. M., A. R. Queiroz, C. Scavone, V. M. Costa, M. Barral-Netto, and A. Abrahamsohn Ide. 2002. Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages. Microbes Infect. 4:23-29.
4. Barral-Netto, M., A. Barral, C. E. Brownell, Y. A. Skeiky, L. R. Ellingsworth, D. R. Twardzik, and S. G. Reed. 1992. Transforming growth factor-beta in leishmanial infection: A parasite escape mechanism. Science 257:545-548.
5. Belkaid, Y., K. F. Hoffmann, S. Mendez, S. Kamhawi, M. C. Udey, T. A. Wynn, and D. L. Sacks. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J. Exp. Med. 194:1497-1506.
6. Belkaid, Y., H. Jouin, and G. Milon. 1996. A method to recover, enumerate and identify lymphomyeloid cells present in an inflammatory dermal site: A study in laboratory mice. J. Immunol. Methods 199:5-25.
7. Belkaid, Y., S. Kamhawi, G. Modi, J. Valenzuela, N. Noben-Trauth, E. Rowton, J. Ribeiro, and D. L. Sacks. 1998. Development of a natural model of cutaneous leishmaniasis: Powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J. Exp. Med. 188:1941-1953.
8. Bennett, C. L., A. Misslitz, L. Colledge, T. Aebischer, and C. C. Blackburn. 2001. Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes. Eur. J. Immunol. 31:876-883.
9. Brown, D. R., and S. L. Reiner. 1999. Polarized helper-T-cell responses against Leishmania major in the absence of B cells. Infect. Immun. 67:266-270.
10. Chen, J., R. Lansford, V. Stewart, F. Young, and F. W. Alt. 1993. RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. USA 90:4528-4532.
11. Da Silva, R. P., B. F. Hall, K. A. Joiner, and D. L. Sacks. 1989. CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages. J. Immunol. 143:617-622.
12. Guy, R. A., and M. Belosevic. 1993. Comparison of receptors required for entry of Leishmania major amastigotes into macrophages. Infect. Immun. 61:1553-1558.
13. Hannum, L. G., A. M. Haberman, S. M. Anderson, and M. J. Shlomchik. 2000. Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J. Exp. Med. 192:931-942.
14. Kane, M. M., and D. M. Mosser. 2001. The role of IL-10 in promoting disease progression in leishmaniasis. J. Immunol. 166:1141-1147.
15. Kima, P. E., S. L. Constant, L. Hannum, M. Colmenares, K. S. Lee, A. M. Haberman, M. J. Shlomchik, and D. McMahon-Pratt. 2000. Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis. J. Exp. Med. 191:1063-1068.
16. Kima, P. E., L. Soong, C. Chicharro, N. H. Ruddle, and D. McMahon-Pratt. 1996. Leishmania-infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells. Eur. J. Immunol. 26:3163-3169.
17. Lendvai, N., X. W. Qu, W. Hsueh, and A. Casadevall. 2000. Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice. J. Immunol. 164:4367-4374.
18. Li, J., C. A. Hunter, and J. P. Farrell. 1999. Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J. Immunol. 162:974-979.
19. Locksley, R. M., S. L. Reiner, F. Hatam, D. R. Littman, and N. Killeen. 1993. Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice. Science 261:1448-1451.
20. Love, D. C., J. D. Esko, and D. M. Mosser. 1993. A heparin-binding activity on Leishmania amastigotes which mediates adhesion to cellular proteoglycans. J. Cell Biol. 123:759-766.
21. Love, D. C., M. Mentink Kane, and D. M. Mosser. 1998. Leishmania amazonensis: The phagocytosis of amastigotes by macrophages. Exp. Parasitol. 88:161-171.
22. Marsh, C. B., M. D. Wewers, L. C. Tan, and B. H. Rovin. 1997. Fc(gamma) receptor cross-linking induces peripheral blood mononuclear cell monocyte chemoattractant protein-1 expression: Role of lymphocyte Fc(gamma)RIII. J. Immunol. 158:1078-1084.
23. Moll, H., H. Fuchs, C. Blank, and M. Rollinghoff. 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol. 23:1595-1601.
24. Mosser, D. M., and P. J. Edelson. 1984. Activation of the alternative complement pathway by Leishmania promastigotes: Parasite lysis and attachment to macrophages. J. Immunol. 132:1501-1505.
25. Mosser, D. M., T. A. Springer, and M. S. Diamond. 1992. Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/CD18). J. Cell Biol. 116:511-520.
26. Peters, C., T. Aebischer, Y. D. Stierhof, M. Fuchs, and P. Overath. 1995. The role of macrophage receptors in adhesion and uptake of Leishmania mexicana amastigotes. J. Cell Sci. 108:3715-3724.
27. Qi, H., V. Popov, and L. Soong. 2001. Leishmania amazonensis-dendritic cell interactions in vitro and the priming of parasite-specific CD4(+) T cells in vivo. J. Immunol. 167:4534-4542.
28. Ritter, U., and H. Moll. 2000. Monocyte chemotactic protein-1 stimulates the killing of leishmania major by human monocytes, acts synergistically with IFN-gamma and is antagonized by IL-4. Eur. J. Immunol. 30:3111-3120.
29. Ritter, U., H. Moll, T. Laskay, E. Brocker, O. Velazco, I. Becker, and R. Gillitzer. 1996. Differential expression of chemokines in patients with localized and diffuse cutaneous American leishmaniasis. J. Infect. Dis. 173:699-709.
30. Rizvi, F. S., M. A. Ouaissi, B. Marty, F. Santoro, and A. Capron. 1988. The major surface protein of Leishmania promastigotes is a fibronectin-like molecule. Eur. J. Immunol. 18:473-476.
31. Rousseau, D., S. Demartino, F. Anjuere, B. Ferrua, K. Fragaki, Y. Le Fichoux, and J. Kubar. 2001. Sustained parasite burden in the spleen of Leishmania infantum-infected BALB/c mice is accompanied by expression of MCP-1 transcripts and lack of protection against challenge. Eur. Cytokine Netw. 12:340-347.
32. Rovin, B. H., L. Lu, and C. B. Marsh. 2001. Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc gamma receptor cross-linking: Role of IL-1beta. J. Leukoc. Biol. 69:435-439.
33. Russell, D. G., and P. Talamas-Rohana. 1989. Leishmania and the macrophage: A marriage of inconvenience. Immunol. Today 10:328-333.
34. Smelt, S. C., S. E. Cotterell, C. R. Engwerda, and P. M. Kaye. 2000. B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology. J. Immunol. 164:3681-3688.
35. Soong, L., C. H. Chang, J. Sun, B. J. Longley, Jr., N. H. Ruddle, R. A. Flavell, and D. McMahon-Pratt. 1997. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. J. Immunol. 158:5374-5383.
36. Soong, L., S. M. Dubolse, P. Kima, and D. McMahon-Pratt. 1995. Leishmania pifanoi amastigote antigens protect mice against cutaneous leishmaniasis. Infect. Immun. 63:3559-3566.
37. Soong, L., J. C. Xu, I. S. Grewal, P. Kima, J. Sun, B. J. Longley, N. H. Ruddle, D. McMahon-Pratt, and R. A. Flavell. 1996. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4:263-273.
38. Sunderkotter, C., M. Kunz, K. Steinbrink, G. Meinardus-Hager, M. Goebeler, H. Bildau, and C. Sorg. 1993. Resistance of mice to experimental leishmaniasis is associated with more rapid appearance of mature macrophages in vitro and in vivo. J. Immunol. 151:4891-4901.
39. Turco, S. J., G. F. Spath, and S. M. Beverley. 2001. Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. Trends Parasitol. 17:223-226.
40. von Stebut, E., Y. Belkaid, B. V. Nguyen, M. Cushing, D. L. Sacks, and M. C. Udey. 2000. Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous leishmaniasis. Eur. J. Immunol. 30:3498-3506.
41. Wei, X. Q., I. G. Charles, A. Smith, J. Ure, G. J. Feng, F. P. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408-411.
42. Wilson, M. E., and K. K. Hardin. 1988. The major concanavalin A-binding surface glycoprotein of Leishmania donovani chagasi promastigotes is involved in attachment to human macrophages. J. Immunol. 141:265-272.
43. Wilson, M. E., and R. D. Pearson. 1988. Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes. Infect. Immun. 56:363-369.