Ketamine blockade of voltage-gated sodium channels: Evidence for a shared receptor site with local anesthetics

Anesthesiology

Volumn 95, Issue 6, 2001, Pages 1406-1413

  Wagner II, Larry E ^a   Gingrich, Kevin J ^a,b   Kulli, John C ^a   Yang, Jay ^a,c  

^a Department of Anesthesiology ^*  (United States)

^b Northwestern Medical Center   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE; LIDOCAINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG RECEPTOR BINDING; IC 50; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; STEADY STATE; VOLTAGE CLAMP; XENOPUS;

EID: 0035209521     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200112000-00020     Document Type: Article

References (34)

1. Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons
2. Tonic block of the sodium and calcium currents by ketamine in isolated guinea pig ventricular myocytes
3. Effects of intravenous anaesthetics on nerve axons
4. Epidural injection of ketamine for perineal analgesia in the horse
5. Intrathecal ketamine for war surgery: A preliminary study under field conditions
6. Intrathecal anesthesia with ketamine
7. Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia
8. Local anesthetics
9. Mechanisms of block
10. Molecular actions of racemic ketamine on human CNS sodium channels
11. Molecular determinants of state-dependent block of Na+ channels by local anesthetics
12. Why do some drugs preferentially block open sodium channels?
13. A critical role for transmembrane segment IVS6 of the sodium channel a subunit in fast inactivation
14. + channels: Evidence that meperidine is a local anesthetic
15. - channels
16. Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels
17. + channels lacking inactivation: Features of a transition-intermediate mechanism
18. Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity
19. Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrythmic drug receptor on rat cardiac myoctes
20. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
21. + channels
22. A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel
23. + channels by a quaternary ammonium ion: Catalysis by a transition-intermediate state?
24. Interaction of batrachotoxin with the local anesthetic receptor site in the transmembrane segment IVS6 of the voltage-gated sodium channel
25. Histopathology after repeated intrathecal injections of preservative-free ketamine in the rabbit: A light and electron microscopic examination
26. Histological findings after long-term infusion of intrathecal ketamine for chronic pain: A case report
27. Subpial vacuolar myelopathy after intrathecal ketamine: Report of a case
28. Neuropathic pain: Aetiology, symptoms, mechanisms, and management
29. Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat model
30. The NMDAreceptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case
31. The effects of ketamine and its enantiomers on the morphine- or dexmedetomidine-induced antinociception after intrathecal administration in rats
32. Spinal coadministration of ketamine reduces the development of tolerance to visceral as well as somatic antinociception during spinal morphine infusion
33. Ketamine attenuates and reverses morphine tolerance in rodents