GABAergic mechanisms in the action of general anesthetics

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 203-207

  Hirota, K ^a   Roth, S H ^b   Fujimura, J ^a   Masuda, A ^a   Ito, Y ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Agent specific action; General anesthetics; Population spike; Rat hippocampal slice

Indexed keywords

ANESTHETIC AGENT; BICUCULLINE METHIODIDE; HALOTHANE; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; ISOFLURANE; PENTOBARBITAL; PROPOFOL; SEVOFLURANE; THIOPENTAL;

ANIMAL TISSUE; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; EVOKED RESPONSE; GABAERGIC SYSTEM; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ANESTHETICS, GENERAL; ANESTHETICS, INTRAVENOUS; ANIMALS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; ISOFLURANE; MALE; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION; THIOPENTAL;

EID: 18544406678     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00186-6     Document Type: Conference Paper

References (13)

1. Albertson, T.E., Tseng, C.C., Joy, R.M., 1991. Propofol modification of evoked/hippocampal dentate inhibition in urethane-anesthetized rats. Anesthesiology 75, 82-90.
2. Albertson, T.E., Walby, W.F., Joy, R.M., 1992. Modification of GABA-mediated inhibition by various injectable anesthetics. Anesthesiology 77, 488-499.
3. Davis, C.H., Davis, S.N., Collingridge, G.L., 1990. Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J. Physiol. (Lond.) 424, 513-531.
4. Higashi, H., Nishi, S., 1982. Effects of barbiturates on the GABA receptor of cat primary afferent neurons. J. Physiol. (Lond.) 332, 299-314.
5. B receptors in area CA1 of rat hippocampus. Br. J. Anaesth. 78, 60-65.
6. Hirota, K., Roth, S.H., 1997b. The effects of sevoflurane on population spikes in CA1 and dentate gyrus of the rat hippocampus in vitro. Anesth. Analg. 85, 426-430.
7. MacIver, M.B., Roth, S.H., 1988. Inhalation anaesthetics exhibit pathway-specific and differential actions on hippocampal synaptic responses in vitro. Br. J. Anaesth. 60, 680-691.
8. MacIver, M.B., Kendig, J.J., 1991. Anesthetic effects on resting membrane potential are voltage-dependent and agent-specific. Anesthesiology 74, 83-88.
9. Mantz, J., Lecharny, J.B., Laudenbach, V., Henzel, D., Peytavin, G., Desmonts, J.M., 1995. Anesthetics affect the uptake but not the depolarization-evoked release of GABA in rat striatal synaptosomes. Anesthesiology 82, 502-511.
10. Nakahiro, M., Yeh, J.Z., Brunner, E., Narahashi, T., 1989. General anesthetics modulate GABA receptor channel complex in rat dorsal ganglion neurons. FASEB J. 3, 1850-1854.
11. Nathan, T., Jensen, M.S., Lambert, J.D.C., 1990. GABAg receptors play a major role in paired-pulse facilitation in area CA1 of the rat hippocampus. Brain Res. 531, 55-65.
12. Nathan, T., Lambert, J.D.C., 1991. Depression of the fast IPSP underlies paired-pulse facilitation in are CA 1 of the rat hippocampus. J. Neurophysiol. 66, 1704-1715.
13. Pearce, R.A., Stringer, J.L., Lothman, E.W., 1989. Effects of volatile anesthetics on synaptic transmission in the rat hippocampus. Anesthesiology 71, 591-598.