Sensitivity and specificity of clinical criteria for hereditary non-polyposis colorectal cancer associated mutations in MSH2 and MLH1

Journal of Medical Genetics

Volumn 37, Issue 9, 2000, Pages 641-645

  Syngal, S ^a,b   Fox, E A ^a   Eng, C ^a   Kolodner, R D ^c   Garber, J E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

Author keywords

Hereditary non polyposis colorectal cancer; MLH1; MSH2

Indexed keywords

ARTICLE; BASE MISPAIRING; CALCULATION; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DNA REPAIR; FAMILY; GENE MUTATION; GENE SEQUENCE; HUMAN; INTERMETHOD COMPARISON; NETHERLANDS; PRACTICE GUIDELINE; PRIORITY JOURNAL; UNITED STATES;

EID: 0033825587     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.37.9.641     Document Type: Article

References (24)

1. Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
2. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
3. The human mutator gene homolog MSH2 and its association with hereditary non-polyposis colorectal cancer
4. Mutation of a mutL homolog in hereditary colon cancer
5. Mutations of a MutS homolog in hereditary non-polyposis colorectal cancer
6. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
7. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
8. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
9. DNA microsatellite instability is suspect in still more cancers
10. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients
11. Clues to the pathogenesis of familial colorectal cancer
12. Microsatellite instability in cancer of the proximal colon
13. Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients
14. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
15. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
16. Clinical findings with implications for genetic testing in families with clustering of colorectal cancer
17. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
18. The International Collaborative Group on hereditary nonpolyposis colorectal cancer (ICG-HNPCC)
19. A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: Meeting highlights and Bethesda Guidelines
20. Hereditary nonpolyposis colorectal cancer: Review of clinical, molecular genetics and counseling aspects
21. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC,Lynch syndrome) proposed by the International Collaborative Group on HNPCC
22. Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer. Implications for clinical predisposition testing
23. Molecular diagnosis of hereditary nonpolyposis colorectal cancer
24. Tumour spectrum in hereditary non-polyposis colorectal cancer (HNPCC) and in families with ″suspected HNPCC″. A population-based study in northern Italy. Colorectal Cancer Study Group