Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: Identification of three novel germ-line mutations in promoter of the hMSH2 gene

Cancer Research

Volumn 62, Issue 1, 2002, Pages 38-42

  Shin, Ki Hyuk ^a   Shin, Joo Ho ^a   Kim, Jung Hwa ^a   Park, Jae Gahb ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; GENE PRODUCT; GUANINE; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BINDING AFFINITY; COLORECTAL CANCER; CONTROLLED STUDY; FAMILIAL CANCER; GENE INSERTION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GERM LINE; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

BASE PAIR MISMATCH; BASE SEQUENCE; CARRIER PROTEINS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GERM-LINE MUTATION; HUMANS; MALE; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PEDIGREE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER;

EID: 0036144263     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
2. Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations
3. Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene
4. Promoter analysis of the human mismatch repair gene hMSH2
5. A core promoter and a frequent single nucleotide polymorphism of the mismatch repair gene hMLH1
6. Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary Nonpolyosis colorectal cancer
7. Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer
8. A general method for isolation for high molecular weight DNA from eukaryotes
9. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines
10. Mismatch repair deficiency associated with overexpression of the MSH3 gene