Signaling induced by erythropoietin and stem cell factor in UT-7/Epo cells: Transient versus sustained proliferation

Stem Cells

Volumn 18, Issue 5, 2000, Pages 366-373

  Erickson Miller, Connie L ^a   Pelus, Louis M ^a,b   Lord, Kenneth A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Differentiation; JAK; MAPK; STAT

Indexed keywords

DNA; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EARLY RESPONSE GENE; ENZYME ACTIVATION; ERYTHROLEUKEMIA CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C FOS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

JANUS;

EID: 0033826402     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.18-5-366     Document Type: Article

References (33)

1. Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-STAT5 DNA binding activity
2. Signaling by the cytokine receptor superfamily
3. Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells
4. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
5. Activation of mitogen-activated protein kinase cascade through erythropoietin receptor
6. Signal transduction by receptors with tyrosine kinase activity
7. Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response
8. Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase
9. JAK2 is associated with the c-kit proto-oncogene and is phosphorylated in response to stem cell factor
10. Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding
11. Erythropoietin activation of AP1 (Fos/Jun)
12. JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells
13. Early events in erythropoietin-induced signaling
14. Functional serum response elements upstream of the growth factor-inducible gene zif268
15. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
16. C-myc expression affects proliferation but not terminal differentiation or survival of explanted erythroid progenitor cells
17. The SRE: A growth factor responsive transcriptional regulator
18. Characterization of cis-acting sequences and trans-acting signals regulating early growth response 1 and c-fos promoters through the granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells
19. Interaction of the erythropoietin and stem-cell-factor receptors
20. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells
21. Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells
22. Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7
23. Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes
24. Interferon γ-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3
25. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis
26. JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor
27. Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines
28. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
29. Proliferative but not nonproliferative responses to granulocyte colony-stimulating factor are associated with rapid activation of the p21ras/MAP kinase signalling pathway
30. Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
31. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
32. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation