Effects of bile acid conjugates on biliary excretion of estradiol-17β- glucuronide in the rat

Hepatology Research

Volumn 7, Issue 1, 1997, Pages 28-34

  Takikawa, Hajime ^a   Sano, Naoyo ^a   Uegaki, Satoko ^a   Yamanaka, Masami ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

Bile acid glucuronide; Bile acid sulfate; Canalicular multispecific organic anion transporter (cMOAT); Eisai hyperbililubinemic rat (EHBR); Estradiol; Estradiol 17 glucuronide

Indexed keywords

BILE ACID; ESTRADIOL 17 GLUCURONIDE;

ANIMAL EXPERIMENT; ARTICLE; BILE COMPOSITION; BILE FLOW; CHOLESTASIS; HYPERBILIRUBINEMIA; INTRAHEPATIC BILE DUCT; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

EID: 0030832456     PISSN: 09284346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4346(97)00368-X     Document Type: Article

References (20)

1. Meyers M, Slikker W, Pascoe G, Vore M. Characterization of cholestasis induced by estradiol-17β-D-glucuronide in the rat. J Pharmacol Exp Ther 1980; 214: 87-93.
2. Sano N, Takikawa H, Yamanaka M. Estradiol 17β-glucuronide-induced cholestasis. Effects of ursodeoxycholate-3-O-glucuronide and 3,7-disulfate. J Hepatol 1993; 1; 241-246.
3. Takikawa H, Yamazaki R, Sano N, Yamanaka M. Biliary excretion of estradiol-17β-glucuronide in the rat. Hepatology 1996; 23: 607-613.
4. Takikawa H, Nishikawa K, Sano N, Yamanaka M, Horie T. Mechanisms of biliary excretion of lithocholate-3-sulfate in Eisai hyperbilirubinemic rats (EHBR). Dig Dis Sci 1995; 40: 1792-1797.
5. Kobayashi K, Sogame Y, Hara H, Hayashi K. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J Biol Chem 1990; 265: 7737-7741.
6. Ishikawa T, Müller M, Klünemann C, Schaub T, Keppler D. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. J Biol Chem 1990; 265: 19279-19286.
7. -) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci USA 1990; 87: 3557-3561.
8. Jansen PLM, Peters WH, Lamers WH. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology 1985; 4: 573-579.
9. Kuipers F, Enserink M, Havinga R, van der Steen AdBM, Hardock MJ, Fevery J, Vonk RJ. Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat. J Clin Invest 1988; 81: 1593-1599.
10. Takikawa H, Sano H, Narita T, et al. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology 1991; 14: 352-360.
11. Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I, Keppler D. Expression of the MRP gene-encoded conjugate pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 1995; 131: 137-150.
12. Paulusma CC, Bosma PJ, Zaman GJR, et al. Congenital jaundice rats with a mutation in a multidrug resistance-associated protein gene. Science 1996; 271: 1126-1128.
13. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y. Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance-associated protein (MRP), is hereditarily defective in Eisai hyperbilirubinemic rats (EHBR). Int Hepatol Commun 1996; 4: 291-298.
14. Kartenbeck J, Leuschner U, Mayer R, Keppler D. Absence of the canalicular isoform of the MRP gene-encoded export pump from the hepatocytes in Dubin-Johnson syndrome. Gastroenterology 1996; 23: 1061-1066.
15. Jedlitschy G, Leier I, Buchholz U, Barnonuin K, Kurz G, Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by MRP gene-encoded conjugate export pump. Cancer Res 1996; 56: 988-994.
16. Takikawa H, Sano N, Minagawa M, Yamanaka M. Effects of ursodeoxycholate, its glucuronide and disulfate and β-muricholate on biliary bicarbonate concentration and biliary lipid excretion. J Hepatol 1992; 15: 77-84.
17. Takikawa H, Sano N, Wako Y, Yamanaka M. Effects of organic anions and bile acids on biliary lipid excretion in hyperbilirubinemic mutant Sprague-Dawley rats. J Hepatol 1993; 17: 247-252.
18. Sathirakul K, Suzuki H, Yasuda K, et al. Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats. J Pharmacol Exp Ther 1993; 265: 1301-1312.
19. Shimamura H, Suzuki H, Hanano M, et al. Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds. J Pharmacol Exp Ther 1994; 271: 370-378.
20. Fernandez-Checa JC, Takikawa H, Horie T, Ookhtens M, Kaplowitz N. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem 1992; 267: 1667-1673.