Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats

Digestive Diseases and Sciences

Volumn 41, Issue 10, 1996, Pages 1953-1958

  Takikawa, Hajime ^a   Sano, Naoyo ^a   Yamanaka, Masami ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

Bile acid; Biliary excretion; Glucuronide; Glutathione; Sulfate; Ursodeoxycholate

Indexed keywords

BILE ACID CONJUGATE; CHENODEOXYCHOLIC ACID; GLUCURONIDE; PRAVASTATIN; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BILE ACID METABOLISM; BILE FLOW; BILE LEVEL; BILIARY EXCRETION; CONTROLLED STUDY; DRUG EFFECT; GLUCURONIDATION; GLUTATHIONE METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SULFATION;

ANIMALS; BILE; GLUTATHIONE; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; TAUROCHENODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

EID: 0029860831     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02093595     Document Type: Article

References (30)

1. Fernandez-Checa JC, Lu S, Ookhtens M, DeLeve L, Runnegar M, Yoshida H, Saeki H, Kannan R, Maddatu T, Garcia-Ruiz C, Kuhlenkamp J. Kaplowitz N: Regulation of hepatic glutathione. In Hepatic Transport and Bile Secretion. Physiology and Pathophysiology. N Tavoloni, PD Berk (eds). New York, Raven Press. 1993, pp 363-395
2. Ballatori N, Truong AT: Relation between biliary glutathione excretion and bile acid-independent bile flow. Am J Physiol 256:G22-G30, 1989
3. Ballatori N, Truong AT: Glutathione as primary osmotic driving force in hepatic bile formation. Am J Physiol 263:G617-G624, 1992
4. Yoshida H, Kuronuma Y, Iijima M, Tamano T, Harada T: Effects of glutathione isopropyl ester on bile flow in glutathione-depleted rats. Arch Int Pharmacodyn 322:105-114, 1993
5. Oude Elferink RPJ. Ottenhoff R, Liefting W, De Haan J, Jansen PLM: Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia. J Clin Invest 84:476-483, 1989
6. Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, Tagaya O: Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rats. Hepatology 14:352-360, 1991
7. Kuipcrs F, Enserink M, Havinga R, van der Steen ABM, Hardonk MJ, Fevery J, Vonk RJ: Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rats. J Clin Invest 81:1593-1399, 1988
8. Kuipers F, Radominska A, Zimniak P, Little JM, Havinga R, Vonk RJ, Lester R: Defective biliary secretion of bile acid-3-O-glucuronides in rats with hereditary hyperbilirubinemia. J Lipid Res 30:1835-1845, 1989
9. Oude Elferink RPJ, DeHaan J, Lambert KJ, Hargey LR, Hofmann AF, Jansen PLM: Selective hepatobiliary transport of nordeoxycholate side chain conjugates in mutant rats with a canalicular transport defect. Hepatology 6:861-865, 1989
10. Fernandez-Checa J, Takikawa H, Horie T, Ookhtens M, Kaplowitz N: Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem 267:1667-1673, 1992
11. Kitamura T, Jansen P, Hardenbrook C, Kamimoto U, Gatmaitan Z, Arias IM: Defective ATP-dependent canalicular transport of organic anions in mutant (TR ) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci USA 87:3557-3561, 1990
12. Kobayashi K, Sogame Y, Hara H, Hayashi K: Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J Biol Chem 265:7737-7741, 1990
13. Ishikawa T, Müller M, Klünemann C, Schaub T, Keppler D: ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione conjugates. J Biol Chem 265:19279-19286, 1990
14. Kobayashi K, Komatsu S, Nishi T, Hara H, Hayashi K: ATP-dependent transport for glucuronides in canalicular plasma membrane vesicles. Biochem Biophys Res Commun 176:622-626, 1991
15. Clarenburg R, Kao CC: Shared and separate pathways for biliary excretion of bilirubin and BSP in rats. Am J Physiol 225:192-220, 1973
16. Mahu J-L, Duvaldestin P, Dhemeaux D, Berthelot P: Biliary transport of cholephilic dyes: Evidence for two different pathways. Am J Physiol 232:E455-E450, 1977
17. Sathirakul K, Suzuki H, Yasuda K, Hanano M, Tagaya O, Horie T, Sugiyama Y: Kinetic analysis of hepatobiliary transport of organic anions in Eisai Hyperbilirubinemic mutant rats (EHBR). J Pharmacol Exp Ther 265:1301-1312, 1993
18. Sathirakul K, Suzuki H, Yamada T, Hanano M, Sugiyama Y: Multiple transport systems for organic anions across the bile canalicular membrane. J Pharmacol Exp Ther 268:65-73, 1994
19. Takenaka O, Horie T, Kobayashi K, Suzuki H, Sugiyama Y: Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia. Pharmacol Res 12:1746-1755, 1995
20. Adachi Y, Kobayashi H, Kurumi Y, Shouji M, Kitano M, Yamamoto T: Bilirubin diglucuronide transport by rat liver canalicular membrane vesicles: Stimulation by bicarbonate ion. Hepatology 14:1251-1258, 1991
21. Takikawa M, Sano N, Yamazaki R, Takamori Y, Yamanaka M: Inhibition of biliary glutathione excretion by lithocholate-3-O-glucuronide: A possible role in initiating lithocholate-3-O-glucuronide-induced cholestasis. Int Hepatol Commun 3:48-51, 1995
22. Takikawa H, Sano N, Kitaura K, Fukumura S, Aiso M, Yamanaka M: Effect of lithocholate-3-sulfate and its amides on biliary excretion of glutathione and phospholipid. Int Hepatol Commun 4:255-262, 1996
23. Takikawa H, Narita T, Sano N, Yamanaka M: Glucuronidation of bile acids by their high-dose infusion into rats. Hepatology 13:1222-1228, 1991
24. Ballatori N, Truong AT, Ma AK, Boyer JL: Determinants of glutathione efflux and biliary GSH/GSSG ratios in perfused rat liver. Am J Physiol 256:0482-0490, 1989
25. Tietze F: Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mammalian blood and other tissues. Anal Biochem 27:502-522, 1969
26. Murphy GM, Billing BH, Bakson DN: A fluorimetiric and enzymatic method tor the estimation of serum total bile acids, J Clin Pathol 23:594-598, 1970
27. Takikawa H, Otsuka H, Beppu T, Seyama Y, Yamakawa T: Quantitative determination of bile acid glucuronides in serum by mass fragmentography. J Biochem 92:985-998. 1982
28. Takikawa H, Sano N, Narita T, Yamanaka M: The ursodeoxycholate dose-dependent formation of ursodeoxycholateglucuronide in the rat and the choleretic potencies. Hepatology 11:743-749, 1990
29. Takikawa H, Sano N, Minagawa K, Yamanaka M: Effects of ursodeoxycholate, its glucuronide and disulfate and β-muricholate on biliary bicarbonate concentration and biliary lipid excretion. J Hepatol 15:77-84, 1992
30. Takikawa H, Sano N, Wako Y, Yamanaka M: Effects of organic anions and bile acids on biliary lipid excretion in hyperbilirubinemic mutant Sprague-Dawley rats. J Hepatol 17:247-252, 1993