Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4

Journal of Immunology

Volumn 170, Issue 12, 2003, Pages 6048-6056

  Schjerven, Hilde ^a   Brandtzaeg, Per ^a   Johansen, Finn Eirik ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 4; NUCLEAR FACTOR I; STAT6 PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; ENHANCER REGION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRON; NUCLEOTIDE SEQUENCE; PIGR GENE; PRIORITY JOURNAL; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION;

EID: 0037605832     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.12.6048     Document Type: Article

References (67)

1. Johansen, F. E., R. Braathen, and P. Brandtzaeg. 2000. Role of J chain in secretory immunoglobulin formation. Scand. J. Immunol. 52:240.
2. Norderhaug, I. N., F. E. Johansen, H. Schjerven, and P. Brandtzaeg. 1999. Regulation of the formation and external transport of secretory immunoglobulins. Crit. Rev. Immunol. 19:481.
3. Mostov, K., and C. S. Kaetzel. 1999. Immunoglobulin transport and the polymeric immunoglobulin receptor. In Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, and J. R. McGhee, eds. Academic Press, San Diego, CA, p. 181.
4. Loman, S., H. M. Jansen, T. A. Out, and R. Lutter. 1999. Interleukin-4 and interferon-γ synergistically increase secretory component gene expression, but are additive in stimulating secretory immunoglobulin A release by Calu-3 airway epithelial cells. Immunology. 96:537.
5. Nilsen, E. M., F. E. Johansen, D. Kvale, P. Krajci, and P. Brandtzaeg. 1999. Different regulatory pathways employed in cytokine-enhanced expression of secretory component and epithelial HLA class I genes. Eur. J. Immunol. 29:168.
6. Krajci, P., K. Tasken, D. Kvale, and P. Brandtzaeg. 1993. Interferon-γ stimulation of messenger RNA for human secretory component (poly-Ig receptor) depends on continuous intermediate protein synthesis. Scand. J. Immunol. 37:251.
7. Piskurich, J. F., J. A. France, C. M. Tamer, C. A. Willmer, C. S. Kaetzel, and D. M. Kaetzel. 1993. Interferon-γ induces polymeric immunoglobulin receptor mRNA in human intestinal epithelial cells by a protein synthesis dependent mechanism. Mol. Immunol. 30:413.
8. Ackermann, L. W., L. A. Wollenweber, and G. M. Denning. 1999. IL-4 and IFN-γ increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells. J. Immunol. 162:5112.
9. Denning, G. M. 1996. IL-4 and IFN-γ synergistically increase total polymeric IgA receptor levels in human intestinal epithelial cells: role of protein tyrosine kinases. J. Immunol. 156:4807.
10. Schjerven, H., P. Brandtzaeg, and F.-E. Johansen. 2000. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J. Immunol. 165:3898.
11. O'Shea, J. J., M. Gadina, and R. D. Schreiber. 2002. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109(Suppl.):S121.
12. Nelms, K., A. D. Keegan, J. Zamorano, J. J. Ryan, and W. E. Paul. 1999. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17:701.
13. Leonard, W. J., and J. J. O'Shea. 1998. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:293.
14. Johansen, F. E., B. A. Bosloven, P. Krajci, and P. Brandtzaeg. 1998. A composite DNA element in the promoter of the polymeric immunoglobulin receptor regulates its constitutive expression. Eur. J. Immunol. 28:1161.
15. Silberg, D. G., E. E. Furth, J. K. Taylor, T. Schuck, T. Chiou, and P. G. Traber. 1997. CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology 113:478.
16. Suh, E., L. Chen, J. Taylor, and P. G. Traber. 1994. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol. Cell. Biol. 14:7340.
17. Silberg, D. G., G. P. Swain, E. R. Suh, and P. G. Traber. 2000. Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 119:961.
18. Kelley, C. M., T. Ikeda, J. Koipally, N. Avitahl, L. Wu, K. Georgopoulos, and B. A. Morgan. 1998. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 8:508.
19. Hahm, K., B. S. Cobb, A. S. McCarty, K. E. Brown, C. A. Klug, R. Lee, K. Akashi, I. L. Weissman, A. G. Fisher, and S. T. Smale. 1998. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12:782.
20. Kvale, D., J. Bartek, L. M. Sollid, and P. Brandtzaeg. 1988. Rapid selection of cultured cells with increased expression of a membrane marker (secretory component). Int. J. Cancer 42:638.
21. Rozen, S., and H. Skaletsky. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132:365.
22. Krasinski, S. D., H. M. Van Wering, M. R. Tannemaat, and R. J. Grand. 2001. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1α. Am. J. Physiol. 281:G69.
23. Ruminy, P., C. Derambure, S. Chandrasegaran, and J. P. Salier. 2001. Long-range identification of hepatocyte nuclear factor-3 (FoxA) high and low-affinity binding sites with a chimeric nuclease. J. Mol. Biol. 310:523.
24. Jahnsen, F. L., R. Haye, E. Gran, P. Brandtzaeg, and F. E. Johansen. 1999. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. J. Immunol. 163:1545.
25. Hosokawa, Y., Y. Maeda, and M. Seto. 1999. Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern. Immunogenetics 50:106.
26. Bai, Y., Y. Akiyama, H. Nagasaki, O. K. Yagi, Y. Kikuchi, N. Saito, K. Takeshita, T. Iwai, and Y. Yuasa. 2000. Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Mol. Carcinog. 28:184.
27. Prywes, R., and R. G. Roeder. 1986. Inducible binding of a factor to the c-fos enhancer. Cell 47:777.
28. Quandt, K., K. Frech, H. Karas, E. Wingender, and T. Werner. 1995. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23:4878.
29. Heinemeyer, T., E. Wingender, I. Reuter, H. Hermjakob, A. E. Kel, O. V. Kel, E. V. Ignatieva, E. A. Ananko, O. A. Podkolodnaya, F. A. Kolpakov, et al. 1998. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26:362.
30. Tronche, F., F. Ringeisen, M. Blumenfeld, M. Yaniv, and M. Pontoglio. 1997. Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome. J. Mol. Biol. 266:231.
31. Ryffel, G. U. 2001. Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J. Mol. Endocrinol. 27:11.
32. Zannis, V. I., H. Y. Kan, A. Kritis, E. Zanni, and D. Kardassis. 2001. Transcriptional regulation of the human apolipoprotein genes. Front. Biosci. 6:D456.
33. Freund, J. N., C. Domon-Dell, M. Kedinger, and I. Duluc. 1998. The Cdx-1 and Cdx-2 homeobox genes in the intestine. Biochem. Cell. Biol. 76:957.
34. Eriksen, K. W., M. Nielsen, K. Kaltoft, A. Svejgaard, M. H. Nissen, C. Ropke, and N. Odum. 2001. Oligonucleotide fishing for STAT6: cross-talk between IL-4 and chemokines. Exp. Clin. Immunogenet. 18:233.
35. Xu, X., Y. L. Sun, and T. Hoey. 1996. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273:794.
36. John, S., U. Vinkemeier, E. Soldaini, J. E. Darnell, Jr., and W. J. Leonard. 1999. The significance of tetramerization in promoter recruitment by Stat5. Mol. Cell. Biol. 19:1910.
37. Ehret, G. B., P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher. 2001. DNA binding specificity of different STAT proteins: comparison of in vitro specificity with natural target sites. J. Biol. Chem. 276:6675.
38. Schjerven, H., Brandtzaeg, P., and F.-E. Johansen. 2001. A novel NF-κB/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-α-induced transcription of the human polymeric Ig receptor. J. Immunol. 167:6412.
39. Kushiro, A., and T. Sato. 1997. Polymeric immunoglobulin receptor gene of mouse: sequence, structure and chromosomal location. Gene 204:277.
40. Thanos, D., and T. Maniatis. 1995. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell 83:1091.
41. Carey, M. 1998. The enhanceosome and transcriptional synergy. Cell 92:5.
42. Arrese. M., and S. J. Karpen. 2002. HNF-1α: have bile acid transport genes found their "master"? J. Hepatol. 36:142.
43. Pontoglio, M. 2000. Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis. J. Am. Soc. Nephrol. 11:S140.
44. Schrem, H., J. Klempnauer, and J. Borlak. 2002. Liver-enriched transcription factors in liver function and development: part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol. Rev. 54:129.
45. Kuo, C., P. Conley, C. Hsieh, U. Francke, and G. Crabtree. 1990. Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc. Natl. Acad. Sci. USA 87:9838.
46. Hu, C., and D. H. Perlmutter. 2002. Cell-specific involvement of HNF-1β in α1-antitrypsin gene expression in human respiratory epithelial cells. Am. J. Physiol. 282:L757.
47. Nammo, T., K. Yamagata, R. Hamaoka, Q. Zhu, T. E. Akiyama, F. J. Gonzalez, J. Miyagawa, and Y. Matsuzawa. 2002. Expression profile of MODY3/HNF-1α protein in the developing mouse pancreas. Diabetologia 45:1142.
48. Martin, M. G., J. Wang, T. W. Li, J. T. Lam, E. M. Gutierrez, R. S. Solorzano-Vargas, and A. H. Tsai. 1998. Characterization of the 5′-flanking region of the murine polymeric IgA receptor gene. Am. J. Physiol. 275:G778.
49. Solorzano-Vargas, R. S., J. Wang, L. Jiang, H. V. Tsai, L. O. Ontiveros, M. A. Vazir, R. J. Aguilera, and M. G. Martin. 2002. Multiple transcription factors in 5′-flanking region of human polymeric Ig receptor control its basal expression. Am. J. Physiol. 283:G415.
50. Hempen, P. M., K. M. Phillips, P. S. Conway, K. H. Sandoval, T. A. Schneeman, H. J. Wu, and C. S. Kaetzel. 2002. Transcriptional regulation of the human polymeric Ig receptor gene: analysis of basal promoter elements. J. Immunol. 169:1912.
51. Piskurich, J. F., K. R. Youngman, K. M. Phillips, P. M. Hempen, M. H. Blanchard, J. A. France, and C. S. Kaetzel. 1997. Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-γ. Mol. Immunol. 34:75.
52. Haelens, A., G. Verrijdt, E. Schoenmakers, P. Alen, B. Peeters, W. Rombauts, and F. Claessens. 1999. The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element. Mol. Cell. Endocrinol. 153:91.
53. Kaetzel, C. S., V. J. Blanch, P. M. Hempen, K. M. Phillips, J. F. Piskurich. and K. R. Youngman. 1997. The polymeric immunoglobulin receptor: structure and synthesis. Biochem. Soc. Trans. 25:475.
54. Blanch, V. J., J. F. Piskurich, and C. S. Kaetzel. 1999. Cutting edge: coordinate regulation of IFN regulatory factor-1 and the polymeric Ig receptor by proinflammatory cytokines. J. Immunol. 162:1232.
55. Taniguchi, T., K. Ogasawara, A. Takaoka, and N. Tanaka. 2001. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19:623.
56. Hu, C., and D. H. Perlmutter. 1999. Regulation of α1-antitrypsin gene expression in human intestinal epithelial cell line Caco-2 by HNF-1α and HNF-4. Am. J. Physiol. 276:G1181.
57. van Wering, H. M., I. L. Huibregtse, S. M. van der Zwan, M. S. de Bie, L. N. Dowling, F. Boudreau, E. H. Rings, R. J. Grand, and S. D. Krasinski. 2002. Physical interaction between GATA-5 and hepatocyte nuclear factor-1α results in synergistic activation of the human lactase-phlorizin hydrolase promoter. J. Biol. Chem. 277:27659.
58. Boudreau, F., Y. Zhu, and P. G. Traber. 2001. Sucrase-isomaltase gene transcription requires the hepatocyte nuclear factor-1 (HNF-1) regulatory element and is regulated by the ratio of HNF-1α to HNF-1β. J. Biol. Chem. 276:32122.
59. Boudreau, F., E. H. Rings, H. M. van Wering, R. K. Kim, G. P. Swain, S. D. Krasinski, J. Moffett, R. J. Grand, E. R. Suh, and P. G. Traber. 2002. Hepatocyte nuclear factor-1α. GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription: implication for the developmental regulation of the sucrase-isomaltase gene. J. Biol. Chem. 277:31909.
60. Soutoglou, E., G. Papafotiou, N. Katrakili, and I. Talianidis. 2000. Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins. J. Biol. Chem. 275:12515.
61. Ban, N., Y. Yamada, Y. Someya, K. Miyawaki, Y. Ihara, M. Hosokawa, S. Toyokuni, K. Tsuda, and Y. Seino. 2002. Hepatocyte nuclear factor-1α recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes 51:1409.
62. Soutoglou, E., B. Viollet, M. Vaxillaire, M. Yaniv, M. Pontoglio, and I. Talianidis. 2001. Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity. EMBO J. 20:1984.
63. Parrizas, M., M. A. Maestro, S. F. Boj, A. Paniagua, R. Casamitjana, R. Gomis, F. Rivera, and J. Ferrer. 2001. Hepatic nuclear factor 1-α directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol. Cell. Biol. 21:3234.
64. Leu. J. I., M. A. S. Crissey, J. P. Leu, G. Ciliberto, and R. Taub. 2001. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol. Cell. Biol. 21:414.
65. McDonald, C., and N. C. Reich. 1999. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. 19:711.
66. Gingras, S., J. Simard, B. Groner, and E. Pfitzner. 1999. p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. Nucleic Acids Res. 27:2722.
67. Shankaranarayanan, P., P. Chaitidis, H. Kuhn, and S. Nigam. 2001. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J. Biol. Chem. 276:42753.