Gliap - A novel untypical L-asparaginase localized to rat brain astrocytes

Journal of Neurochemistry

Volumn 85, Issue 5, 2003, Pages 1117-1125

  Dieterich, Daniela C ^a,b   Landwehr, Marco ^a   Reissner, Carsten ^a   Smalla, Karl Heinz ^a   Richter, Karin ^c   Wolf, Gerald ^c   Böckers, Tobias M ^a,b   Gundelfinger, Eckart D ^a   Kreutz, Michael R ^a  

^a LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Aspartate; Brain; Glia; Glial endfeet; Glycosylasparaginase

Indexed keywords

AMINO ACID; ASPARAGINASE; ASPARAGINE; ASPARTIC ACID; NUCLEOTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BRAIN; CELL FRACTIONATION; DEAMINATION; ENZYME ACTIVITY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; ASPARAGINASE; ASTROCYTES; BASE SEQUENCE; BRAIN; CLONING, MOLECULAR; CYTOSOL; GLUTATHIONE TRANSFERASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; MAMMALIA;

EID: 0037565531     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01766.x     Document Type: Article

References (25)

1. Aghaiypour K., Wlodawer A. and Lubkowski J. (2001) Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu? Biochim. Biophys. Acta 1550, 117-128.
2. Asselin B. L. (1999) The three asparaginases. Comparative pharmacology and optimal use in childhood leukemia. Adv. Exp. Med. Biol. 457, 621-629.
3. Aung H. P., Bocola M., Schleper S. and Rohm K. H. (2000) Dynamics of a mobile loop at the active site of Escherichia coli asparaginase. Biochim. Biophys. Acta 1481, 349-359.
4. Borek D. and Jaskolski M. (2001) Sequence analysis of enzymes with asparaginase activity. Acta Biochim. Pol. 48, 893-902.
5. Bush L. A., Herr J. C., Wolkowicz M., Sherman N. E., Shore A. and Flickinger C. J. (2002) A novel Asparaginase-like protein is a sperm autoantigen in rats. Mol. Reprod. Dev. 62, 233-247.
6. Clavell L. A., Gelber R. D., Cohen H. J., Hitchcock-Bryan S., Cassady J. R., Tarbell N. J., Blattner S. R., Tantravahi R., Leavitt P. and Sallan S. E. (1986) Four-agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia. N. Engl. J. Med. 315, 657-663.
7. Guex N. and Peitsch M. C. (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18, 2714-2723.
8. Gundersen V. and Storm-Mathisen J. (2000) Aspartate - neurochemical evidence for a transmitter role, in Handbook of Chemical Neuroanatomy, Vol. 18: Glutamate (Ottersen O. P. and Storm-Mathisen J., eds), pp. 45-62. Elsevier Science, Amsterdam.
9. Henderson P. J. F. (1992) Enzyme Assays - A Practical Approach (Eisenthal R. and Danson M. J., eds). Oxford University Press, Oxford.
10. Johannessen C. U., Qu H., Sonnewald U., Hassel B. and Fonnum F. (2001) Estimation of aspartate synthesis in GABAergic neurons in mice by 13 C NMR spectroscopy. Neuroreport 12, 3729-3732.
11. Kaartinen V., Mononen T., Laatikainen R. and Mononen I. (1992) Substrate specificity and reaction mechanism of human glycoasparaginase. The N-glycosidic linkage of various glycoasparagines is cleaved through a reaction mechanism similar to L-asparaginase. J. Biol. Chem. 267, 6855-6858.
12. Laskowski R. A., Rullmannn J. A., MacArthur M. W., Kaptein R. and Thomton J. M. (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J. Biomol. NMR 8, 477-486.
13. Laube G., Seidenbecher C. I., Richter K. et al. (2002) The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system. Mol. Cell. Neurosci. 19, 459-475.
14. Oinonen C. and Rouvinen J. (2000) Structural comparison of Ntn-hydrolases. Protein Sci. 9, 2329-2337.
15. Reissig J. L., Stominger J. L. and Leloir L. F. (1955) A modified colorimetric method for the estimation of N-Acetylamino sugars. J. Biol. Chem. 297, 959.
16. Risley J. M., Huang D. H., Kaylor J. J., Malik J. J., Xia Y. Q. and York W. M. (2001) Glycosylasparaginase activity requires the alpha-carboxyl group, but not the alpha-amino group, on N(4)-(2-Acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine. Arch. Biochem. Biophys. 391, 165-170.
17. Rodriguez R., Chinea G., Lopez N., Pons T. and Vriend G. (1998) Homology modeling, model and software evaluation: three related resources. Bioinformatics 14, 523-528.
18. Saarela J., Laine M., Tikkanen R., Oinonen C., Jalanko A., Rouvinen J. and Peltonen L. (1998) Activation and oligomerization of aspartylglucosaminidase. J. Biol. Chem. 273, 25 320-25 328.
19. Seidenbecher C. I., Langnäse K., Sanmarti-Vila L., Böckers T. M., Smalla K. H., Sabel B. A., Garner C. C., Gundelfinger E. D. and Kreutz M. R. (1998) Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment. J. Biol. Chem. 273, 21 324-21 331.
20. Swain A. L., Jaskolski M., Housset D., Rao J. K. and Wlodawer A. (1993) Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy. Proc. Natl Acad. Sci. USA 90, 1474-1478.
21. Tikkanen R., Riikonen A., Oinonen C., Rouvinen R. and Peltonen L. (1996) Functional analyses of active site residues of human lysosomal aspartylglucosaminidase: implications for catalytic mechanism and autocatalytic activation. EMBO J. 15, 2954-2960.
22. Tollersrud O. K. and Aronson N. N. Jr (1989) Purification and characterization of rat liver glycosylasparaginase. Biochem. J. 260, 101-108.
23. Xu Q., Buckley D., Guan C. and Guo H. C. (1999) Structural insights into the mechanism of intramolecular proteolysis. Cell 98, 651-661.
24. Xuan J., Tarentino A. L., Grimwood B. G., Plummer T. H., Cui T., Guan C. and Van Roey P. (1998) Crystal structure of glycosylasparaginase from Flavobacterium meningosepticum. Protein Sci. 7, 774-781.
25. Ylikangas P. and Mononen I. (2000) A fluorometric assay for L-asparaginase activity and monitoring of L-asparaginase therapy. Anal. Biochem. 280, 42-45.