Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans

Journal of Applied Physiology

Volumn 94, Issue 6, 2003, Pages 2113-2118

  Wilson, Thad E ^a   Shibasaki, Manabu ^a   Cui, Jian ^a   Levine, Benjamin D ^a,b   Crandall, Craig G ^a,b  

^a PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Intradermal microdialysis; Norepinephrine; Simulated microgravity; Skin blood flow; Venoarteriolar reflex

Indexed keywords

NORADRENALIN;

ADULT; ARTICLE; BED REST; BICYCLE ERGOMETRY; DOSE RESPONSE; EXERCISE; FEMALE; FOREARM BLOOD FLOW; HEAD TILTING; HEART RATE; HUMAN; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; LEG BLOOD FLOW; MALE; MICRODIALYSIS; NONLINEAR REGRESSION ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SKIN BLOOD FLOW; VASOCONSTRICTION;

EID: 0037562067     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00067.2002     Document Type: Article

References (33)

1. Blamick CA, Goldwater DJ, and Convertino VA. Leg vascular responsiveness during acute orthostasis following simulated weightlessness. Aviat Space Environ Med 59: 40-43, 1988.
2. Blomqvist CG and Stone HL. Cardiovascular adjustments to gravitational stress. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 2, chapt. 28, p. 1025-1063.
3. Buckey JC Jr, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, and Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 81: 7-18, 1996.
4. Chobanian AV, Lille RD, Tercyak A, and Blevins P. The metabolic and hemodynamic effects of prolonged bed rest in normal subjects. Circulation 49: 551-559, 1974.
5. Convertino VA. Exercise and adaptation to microgravity environments. In: Handbook of Physiology: Environmental Physiology. Bethesda, MD: Am. Physiol. Soc, 1996, sect. 4, vol. II, chapt. 36, 1996, p. 815-843.
6. Convertino VA, Polet JL, Engelke KA, Hoffler GW, Lane LD, and Blomqvist CG. Evidence for increased β-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans. Am J Physiol Regul Integr Comp Physiol 273: R93-R99, 1997.
7. Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T, Iwase S, Saito M, Sugiyama Y, Ertl AC, Biaggioni I, Diedrich A, Robertson RM, Zuckerman JH, Lane LD, Ray CA, White RJ, Pawelczyk JA, Buckey JC Jr, Baisch FJ, Blomqvist CG, Robertson D, and Eckberg DL. Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre. J Physiol 538: 309-320, 2002.
8. Crandall CG, Etzel RA, and Johnson JM. Evidence of functional β-adrenoceptors in the cutaneous vasculature. Am J Physiol Heart Circ Physiol 273: H1038-H1043, 1997.
9. Crandall CG, Shibasaki M, and Yen TC. Evidence that the cutaneous venoarteriolar response is not mediated by adrenergic mechanisms. J Physiol 538: 599-605, 2001.
10. Delp MD. Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading. J Appl Physiol 86: 1178-1184, 1999.
11. Delp MD, Holder-Binkley T, Laughlin MH, and Hasser EM. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J Appl Physiol 75: 2620-2628, 1993.
12. Fortney SM, Schneider VS, and Greenleaf JE. The physiology of bed rest. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, vol. II, chapt. 39, p. 889-939.
13. Gabrielsen A, Norsk P, Videbaek R, and Henriksen O. Effect of microgravity on forearm subcutaneous vascular resistance in humans. J Appl Physiol 79: 434-438, 1995.
14. Gabrielsen A, Suzuki Y, and Norsk P. Preservation of venoarteriolar reflex in the skin following 20 days of head down bed rest in humans. J Gravit Physiol 6: P103-P104, 1999.
15. Henriksen O. Sympathetic reflex control of blood flow in human peripheral tissues. Acta Physiol Scand Suppl 603: 33-39, 1991.
16. Henriksen O, Nielsen SL, and Paaske WP. Autoregulation of blood flow in human adipose tissue. Acta Physiol Scand 89: 531-537, 1973.
17. Henriksen O and Sejrsen P. Local reflex in microcirculation in human cutaneous tissue. Acta Physiol Scand 98: 227-231, 1976.
18. Henriksen O and Sejrsen P. Local reflex in microcirculation in human skeletal muscle. Acta Physiol Scand 99: 19-26, 1977.
19. Kellogg DL Jr, Liu Y, Kosiba IF, and O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 86: 1185-1190, 1999.
20. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC Jr, Cooke WH, Baisch FJ, Eckberg DL, and Blomqvist CG. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol 538: 331-340, 2002.
21. Maass H, Transmontano J, and Baisch F. Response of adrenergic receptors to 10 days head-down tilt bedrest. Acta Physiol Scand Suppl 604: 61-68, 1992.
22. Overton JM and Tipton CM. Effect of hindlimb suspension on cardiovascular responses to sympathomimetics and lower body negative pressure. J Appl Physiol 68: 355-362, 1990.
23. Pawelczyk JA and Levine BD. Limb vascular responsiveness to adrenergic agonists following physical deconditioning (Abstract). Med Sci Sports Exerc 27: S31, 1995.
24. Pawelczyk JA and Levine BD. Heterogeneous responses of human limbs to infused adrenergic agoinists: a gravitational effect? J Appl Physiol 92: 2105-13, 2002.
25. Pawelczyk JA, Zuckerman JH, Blomqvist CG, and Levine BD. Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol Heart Circ Physiol 280: H2230-H2239, 2001.
26. Purdy RE, Duckles SP, Krause DN, Rubera KM, and Sara D. Effect of simulated microgravity on vascular contractility. J Appl Physiol 85: 1307-1315, 1998.
27. Rowell LB. Human Cardiovascular Control. Oxford, UK: Oxford Univ. Press, 1993.
28. 1-adrenoceptors in rat vena cava. J Appl Physiol 78: 1882-1888, 1995.
29. Schneider SM, Watenpaugh DE, Lee SM, Ertl AC, Williams WJ, Ballard RE, and Hargens AR. Lower-body negative-pressure exercise and bed-rest-mediated orthostatic intolerance. Med Sci Sports Exerc 34: 1446-1453, 2002.
30. Shoemaker JK, Hogeman CS, Silber DH, Gray K, Herr M, and Sinoway LI. Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses. J Appl Physiol 84: 1756-1762, 1998.
31. Vissing SF, Secher NH, and Victor RG. Mechanisms of cutaneous vasoconstriction during upright posture. Acta Physiol Scand 159: 131-138, 1997.
32. Watenpaugh DE, Ballard RE, Schneider SM, Lee SM, Ertl AC, William JM, Boda WL, Hutchinson KJ, and Hargens AR. Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol 89: 218-227, 2000.
33. Wautenpaugh DE and Hargens AR. The cardiovascular system in microgravity. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, vol. I, chapt. 29, p. 631-674.