Regulation of muscle sympathetic nerve activity after bed rest deconditioning

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 5 49-5, 2001, Pages

  Pawelczyk, James A ^a,b   Zuckerman, Julie H ^b   Blomqvist, C Gunnar ^b   Levine, Benjamin D ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adrenergic nervous system; Sympathetic reflex; Vasoconstriction

Indexed keywords

ADRENERGIC SYSTEM; ADULT; ARTICLE; BED REST; FEMALE; HEART MUSCLE; HEMODYNAMIC PARAMETERS; HUMAN; HUMAN EXPERIMENT; HYPOVOLEMIA; MALE; MUSCLE ATROPHY; NORMAL HUMAN; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; STIMULUS RESPONSE; SYMPATHETIC NERVE; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0035031155     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.5.h2230     Document Type: Article

References (45)

1. Akers R and Buskirk ER. An underwater weighing system utilizing "force cube" transducers. J Appl Physiol 26: 649-652, 1969.
2. Arbeille P, Gauquelin G, Pottier JM, Pourcelot L, Guell A, and Gharib C. Results of a 4-week head-down tilt with and without LBNP countermeasure. II. Cardiac and peripheral hemodynamics-comparison with a 25-day spaceflight. Aviat Space Environ Med 63: 9-13, 1992.
3. Beck L, Baisch F, Gaffney FA, Buckey JC, Arbeille P, Patat F, ten Harkel AD, Hillebrecht A, Schulz H, and Karemaker JM. Cardiovascular response to lower body negative pressure before, during, and after ten days head-down tilt bedrest. Acta Physiol Scand Suppl 604: 43-52, 1992.
4. Bishop VS, Malliani A, and Thoren P. Cardiac mechanoreceptors. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 2, chapt. 15, p. 497-556.
5. Buckey JCJ, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, and Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 81: 7-18, 1996.
6. Butler GC, Xing HC, Northey DR, and Hughson RL. Reduced orthostatic tolerance following 4 h head-down tilt. Eur J Appl Physiol 62: 26-30, 1991.
7. Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, and Vernikos-Danellis J. Carotid baroreflex response following 30 days exposure to simulated microgravity. Physiologist 32: S67-S68, 1989.
8. Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, and Vernikos-Danellis J. Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J Appl Physiol 68: 1458-1464, 1990.
9. Convertino VA, Doerr DF, and Stein SL. Changes in size and compliance of the calf after 30 days of simulated microgravity. J Appl Physiol 66: 1509-1512, 1989.
10. Convertino VA, Polet JL, Engelke KA, Hoffler GW, Lane LD, and Blomqvist CG. Evidence for increased β-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans. Am J Physiol Regulatory Integrative Comp Physiol 273: R93-R99, 1997.
11. Eckberg DL and Fritsch JM. Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Acta Physiol Scand Suppl 604: 69-76, 1992.
12. Eklund B, Kaijser L, and Knutsson E. Blood flow in resting (contralateral) arm and leg during isometric contraction. J Physiol (Lond) 240: 111-124, 1974.
13. Essandoh LK, Houston DS, Vanhoutte PM, and Shepherd JT. Differential effects of lower body negative pressure on forearm and calf blood flow. J Appl Physiol 61: 994-998, 1986.
14. Fagius J and Wallin BG. Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clin Auton Res 3: 201-205, 1993.
15. Foldager N and Blomqvist CG. Repeated plasma volume determination with the Evans Blue dye dilution technique: the method and a computer program. Comput Biol Med 21: 35-41, 1991.
16. Fortney SM, Schneider VS, and Greenleaf JE. The physiology of bed rest. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, vol. II, chapt. 39, p. 889-942.
17. Fritsch-Yelle JM, Charles JB, Jones MM, Beightol LA, and Eckberg DL. Spaceflight alters autonomic regulation of arterial pressure in humans. J Appl Physiol 77: 1776-1783, 1994.
18. Fritsch-Yelle JM, Whitson PA, Bondar RL, and Brown TE. Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol 81: 2134-2141, 1996.
19. Fritsch JM, Charles JB, Bennett BS, Jones MM, and Eckberg DL. Short-duration spaceflight impairs human carotid baroreceptor-cardiac reflex responses. J Appl Physiol 73: 664-671, 1992.
20. Gharib C, Maillet A, Gauquelin G, Allevard AM, Guell A, Cartier R, and Arbeille P. Results of a 4-week head-down tilt with and without LBNP countermeasure. I. Volume regulating hormones. Aviat Space Environ Med 63: 3-8, 1992.
21. Goldstein DS, Vernikos J, Holmes C, and Convertino VA. Catecholaminergic effects of prolonged head-down bed rest. J Appl Physiol 78: 1023-1029, 1995.
22. Hokanson DE, Sumner DS, and Strandness DE. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng BME-22: 25-29, 1975.
23. Jacob G, Costa F, Shannon J, Robertson D, and Biaggioni I. Dissociation between neural and vascular responses to sympathetic stimulation: contribution of local adrenergic receptor function. Hypertension 35: 76-81, 2000.
24. Joyner MJ, Shepherd JT, and Seals DR. Sustained increases in sympathetic outflow during prolonged lower body negative pressure in humans. J Appl Physiol 68: 1004-1009, 1990.
25. Levine BD, Buckey JC, Fritsch JM, Yancy CW Jr, Watenpaugh DE, Snell PG, Lane LD, Eckberg DL, and Blomqvist CG. Physical fitness and cardiovascular regulation: mechanisms of orthostatic intolerance. J Appl Physiol 70: 112-122, 1991.
26. Levine BD, Lane LD, Buckey JC, Friedman DB, and Blomqvist CG. Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance. Circulation 84: 1016-1023, 1991.
27. Levine BD, Zuckerman JH, and Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96: 517-525, 1997.
28. Mano T, Iwase S, and Kamiya A. Sympathetic nerve responses in humans to short and long term simulation of microgravity. J Gravit Physiol 5: 93-96, 1999.
29. Pawelczyk JA and Levine BD. Cardiovascular responses to rapid volume infusion: the human Bainbridge reflex. Circulation 92: 169, 1995.
30. Pawelczyk JA, Levine BD, Prisk GK, Shykoff BE, Elliot AR, and Rosow E. Accuracy and precision of flight systems for determination of cardiac output by soluble gas rebreathing. Proceedings of the NASA/AIAA Life Sciences and Space Medicine Conference, Houston, TX, February 1995.
31. Rea RF, Hamdan M, Clary MP, Randels MJ, Dayton PJ, and Strauss RG. Comparison of muscle sympathetic responses to hemorrhage and lower body negative pressure in humans. J Appl Physiol 70: 1401-1405, 1991.
32. Rea RF and Wallin BG. Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans. J Appl Physiol 66: 2778-2781, 1989.
33. Robertson D, Convertino VA, and Vernikos J. The sympathetic nervous system and the physiologic consequences of space-flight: a hypothesis. Am J Med Sci 308: 126-132, 1994.
34. Scherrer U, Vissing SF, and Victor RG. Effects of lower-body negative pressure on sympathetic nerve responses to static exercise in humans. Microneurographic evidence against cardiac baroreflex modulation of the exercise pressor reflex. Circulation 78: 49-59, 1988.
35. Seals DR. Sympathetic neural discharge and vascular resistance during exercise in humans. J Appl Physiol 66: 2472-2478, 1989.
36. Shoemaker JK, Hogeman CS, Leuenberger UA, Herr MD, Gray K, Silber DH, and Sinoway LI. Sympathetic discharge and vascular resistance after bed rest. J Appl Physiol 84: 612-617, 1998.
37. Shoemaker JK, Hogeman CS, and Sinoway LI. Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. Am J Physiol Regulatory Integrative Comp Physiol 277: R1084-R1090, 1999.
38. Shoemaker JK and Sinoway LI. Sympathetic contributions to orthostatic tolerance and vascular tone following bed rest. Proceedings of the 1st Biennial Space Biomedical Investigators' Workshop, Clear Lake, TX, 1999.
39. Sigaudo D, Fortrat JO, Allevard AM, Maillet A, Cottet-Emard JM, Vouillarmet A, Hughson RL, Gauquelin-Koch G, and Gharib C. Changes in the sympathetic nervous system induced by 42 days of head-down bed rest. Am J Physiol Heart Circ Physiol 274: H1875-H1884, 1998.
40. Sundlöf G and Wallin BG. The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol (Lond) 272: 383-397, 1977.
41. Sundlöf G and Wallin BG. Effect of lower body negative pressure on human muscle nerve sympathetic activity. J Physiol (Lond) 278: 525-532, 1978.
42. Taylor JA, Halliwill JR, Brown TE, Hayano J, and Eckberg DL. "Non-hypotensive" hypovolaemia reduces ascending aortic dimensions in humans. J Physiol (Lond) 483: 289-298, 1995.
43. Taylor JA, Joyner MJ, Chase PB, and Seals DR. Differential control of forearm and calf vascular resistance during one-leg exercise. J Appl Physiol 67: 1791-1800, 1989.
44. Triebwasser JH, Johnson RL, Burpo RP, Campbell JC, Reardon WC, and Blomqvist CG. Noninvasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer measurements. Aviat Space Environ Med 48: 203-209, 1977.
45. Vissing SF, Scherrer U, and Victor RG. Relation between sympathetic outflow and vascular resistance in the calf during perturbations in central venous pressure. Evidence for cardiopulmonary afferent regulation of calf vascular resistance in humans. Circ Res 65: 1710-1717, 1989.