The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease

Brain Research

Volumn 961, Issue 1, 2003, Pages 88-91

  Liu, Hsing Cheng ^a,b   Leu, Sy Jye ^b   Chang, Jan Gowth ^c   Sung, Shing Ming ^a   Hsu, Wei Chen ^d   Lee, Long Shyong ^d   Hu, Chaur Jong ^d  

^a TAIPEI CITY PSYCHIATRIC CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d JEN AI HOSPITAL   (Taiwan)

Author keywords

Alzheimer's disease; Amyloid beta; Amyloid precursor protein; Beta site APP cleaving enzyme

Indexed keywords

BETA SECRETASE;

AGED; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENETIC CODE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; STATISTICAL ANALYSIS;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; FEMALE; GENE FREQUENCY; HUMANS; MALE; POLYMORPHISM, GENETIC;

EID: 0037462293     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03849-0     Document Type: Article

References (13)

1. Bodendorf U., Fischer F., Bodian D., Multhaup G., Paganetti P. A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein. J. Biol. Chem. 276:2001;13019-13023.
2. Clippingdale A.B., Wade J.D., Barrow C.J. The amyloid-beta peptide and its role in Alzheimer's disease. J. Pept. Sci. 7:2001;227-249.
3. Cruts M., Dermaut B., Rademakers R., Roks G., Van den B.M., Munteanu G., van Duijn C.M., Van Broeckhoven C. Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease. Neurosci. Lett. 313:2001;105-107.
4. Hussain I., Powell D., Howlett D.R., Tew D.G., Meek T.D., Chapman C., Gloger I.S., Murphy K.E., Southan C.D., Ryan D.M., Smith T.S., Simmons D.L., Walsh F.S., Dingwall C., Christie G. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14:1999;419-427.
5. Lin X., Koelsch G., Wu S., Downs D., Dashti A., Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc. Natl. Acad. Sci. USA. 97:2000;1456-1460.
6. Murphy T., Yip A., Brayne C., Easton D., Evans J.G., Xuereb J., Cairns N., Esiri M.M., Rubinsztein D.C. The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease. Neuroreport. 13:2001;631-634.
7. Nowotny P., Kwon J.M., Chakraverty S., Nowotny V., Morris J.C., Goate A.M. Association studies using novel polymorphisms in BACE1 and BACE2. Neuroreport. 13:2001;1799-1802.
8. Roberds S.L., Anderson J., Basi G., Bienkowski M.J., Branstetter D.G., Chen K.S., Freedman S.B., Frigon N.L., Games D., Hu K., Johnson-Wood K., Kappenman K.E., Kawabe T.T., Kola I., Kuehn R., Lee M., Liu W., Motter R., Nichols N.F., Power M., Robertson D.W., Schenk D., Schoor M., Shopp G.M., Shuck M.E., Sinha S., Svensson K.A., Tatsuno G., Tintrup H., Wijsman J., Wright S., McConlogue L. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 10:2001;1317-1324.
9. Sinha S., Anderson J.P., Barbour R., Basi G.S., Caccavello R., Davis D., Doan M., Dovey H.F., Frigon N., Hong J., Jacobson-Croak K., Jewett N., Keim P., Knops J., Lieberburg I., Power M., Tan H., Tatsuno G., Tung J., Schenk D., Seubert P., Suomensaari S.M., Wang S., Walker D., John V. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 402:1999;537-540.
10. Sinha S., Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc. Natl. Acad. Sci. USA. 96:1999;12049-12053.
11. Tanzi R.E., Bertram L. New frontiers in Alzheimer's disease genetics. Neuron. 32:2001;181-184.
12. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:1999;735-741.
13. Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M., Brashier J.R., Stratman N.C., Mathews W.R., Buhl A.E., Carter D.B., Tomasselli A.G., Parodi L.A., Heinrikson R.L., Gurney M.E. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature. 402:1999;533-537.