Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor

Biochemical and Biophysical Research Communications

Volumn 301, Issue 4, 2003, Pages 848-854

  Piiper, Albrecht ^a   Lutz, Manfred P ^b   Cramer, Henning ^c   Elez, Robert ^a   Kronenberger, Bernd ^a   Dikic, Ivan ^d   Müller Esterl, Werner ^e   Zeuzem, Stefan ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^e GOETHE UNIVERSITY   (Germany)

Author keywords

cAMP; EGF; MAP kinase; PC12; PKA

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FORSKOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOAMINO ACID; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; SERINE; THREONINE; TYROSINE;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL MEMBRANE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

EID: 0037458957     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00055-X     Document Type: Article

References (32)

1. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 103:2000;211-225.
2. Leserer M., Gschwind A., Ullrich A. Epidermal growth factor receptor signal transactivation. IUBMB Life. 49:2000;405-409.
3. Luttrell L.M., Daaka Y., Lefkowitz R.J. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr. Opin. Cell Biol. 11:1999;177-183.
4. Burgering B.M.T., Pronk G.J., van Weeren P.C., Chardin P., Bos J.L. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12:1993;4211-4220.
5. Wu J., Dent P., Jelinek T., Wolfman A., Weber M.J., Sturgill T.W. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine. 3′,5′-monophosphate Science. 262:1993;1065-1069.
6. Young S.W., Dickens M., Tavaré J.M. Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters. FEBS Lett. 338:1994;212-216.
7. Frodin M., Peraldi P., van Obberghen E. Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J. Biol. Chem. 269:1994;6207-6214.
8. Erhardt P., Troppmair J., Rapp U.R., Cooper G.M. Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells. Mol. Cell. Biol. 15:1995;5524-5530.
9. Vossler M.R., Yao H., York R.D., Pan M.G., Rim C.S., Stork P.J.S. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell. 89:1997;73-82.
10. Klinger M., Kudlacek O., Seidel M., Freissmuth M., Sexl V. MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases. J. Biol. Chem. 277:2002;32490-32497.
11. Piiper A., Dikic I., Lutz M.P., Cramer H., Kronenberger B., Elez R., Müller-Esterl W., Zeuzem S. Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J. Biol. Chem. 277:2002;43623-43630.
12. Walsh D.A., Van Patten S.M. Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB J. 8:1994;1227-1236.
13. de Rooij J., Zwartkruis F.J., Verheijen M.H., Cool R.H., Nijman S.M., Wittinghofer A., Bos J.L. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 396:1998;474-477.
14. Kawasaki H., Springett G.M., Mochizuki N., Toki S., Nakaya M., Matsuda M., Housman D.E., Graybiel A.M. A family of cAMP-binding proteins that directly activate Rap1. Science. 282:1998;2275-2279.
15. Ginty D.D., Glowacka D., DeFranco C., Wagner J.A. Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities. J. Biol. Chem. 266:1991;15325-15333.
16. Traverse S., Seedorf K., Paterson H., Marshall C.J., Cohen P., Ullrich A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4:1994;694-701.
17. Piiper A., Stryjek-Kaminska D., Klengel R., Zeuzem S. CCK, carbachol, and bombesin activate distinct PLC-beta isoenzymes via Gq/11 in rat pancreatic acinar membranes. Am. J. Physiol. 272:1997;G135-G140.
18. Piiper A., Stryjek-Kaminska D., Klengel R., Zeuzem S. Epidermal growth factor inhibits bombesin-induced activation of phospholipase C-beta1 in rat pancreatic acinar cells. Gastroenterology. 113:1997;1747-1755.
19. Piiper A., Gebhardt R., Kronenberger B., Giannini C.D., Elez R., Zeuzem S. Pertussis toxin inhibits cholecystokinin- and epidermal growth factor-induced mitogen-activated protein kinase activation by disinhibition of the cAMP signaling pathway and inhibition of c-Raf-1. Mol. Pharmacol. 58:2000;608-613.
20. Cramer H., Müller-Esterl W., Schroeder C. Subtype-specific desensitization of human endothelin ETA and ETB receptors reflects differential receptor phosphorylation. Biochemistry. 36:1997;13325-13332.
21. Miyazaki Y., Shinomura Y., Tsutsui S., Zushi S., Higashimoto Y., Kanayama S., Higashiyama S., Taniguchi N., Matsuzawa Y. Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor. Gastroenterology. 116:1999;78-89.
22. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 402:1999;884-888.
23. Barbier A.J., Poppelton H.M., Yigzaw Y., Mullenix J.B., Wiepz G.J., Bertics P.J., Patel T.B. Transmodulation of epidermal growth factor receptor function by cyclic AMP-dependent protein kinase. J. Biol. Chem. 274:1999;14067-14073.
24. Hunter T., Cooper J.A. Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell. 24:1981;741-752.
25. Countaway J.L., McQuilkin P., Gironès N., Davis R.J. Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation. J. Biol. Chem. 265:1990;3407-3416.
26. Carpenter G., Cohen S. Epidermal growth factor. J. Biol. Chem. 265:1990;7709-7712.
27. Rackoff W.R., Rubin R.A., Earp H.S. Phosphorylation of the hepatic EGF receptor with cAMP-dependent protein kinase. Mol. Cell. Endocrinol. 34:1984;113-119.
28. Ghosh-Dastidar P., Fox C.F. cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors. J. Biol. Chem. 259:1984;3864-3869.
29. Cook S.J., McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 262:1993;1069-1072.
30. Bos J.L., de Rooij J., Reedquist K.A. Rap1 signalling: adhering to new models. Nat. Rev. Mol. Cell. Biol. 2:2001;369-377.
31. Enserink J.M., Christensen A.E., de Rooij J., Van Triest M., Schwede F., Genieser H.G., Doskeland S.O., Blank J.L., Bos J.L. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat. Cell Biol. 4:2002;901-906.
32. Ambrosini A., Tininini S., Barassi A., Racagni G., Sturani E., Zippel R. cAMP cascade leads to Ras activation in cortical neurons. Brain Res. Mol. Brain Res. 75:2000;54-60.