A structural model for the inhibition of calpain by calpastatin: Crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor

Journal of Molecular Biology

Volumn 328, Issue 1, 2003, Pages 131-146

  Todd, Bice ^a   Moore, Dwight ^a   Deivanayagam, Champion C S ^a   Lin, Guang Da ^a   Chattopadhyay, Debasish ^a,b   Maki, Masatoshi ^c   Wang, Kevin K W ^d   Narayana, Sthanam V L ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c NAGOYA UNIVERSITY   (Japan)

^d PFIZER INC   (United States)

Author keywords

Calcium; Calpain; Calpastatin; Protease; Structure

Indexed keywords

CALPAIN; CALPAIN 3 (4 IODOPHENYL) 2 MERCAPTO 2 PROPENOIC ACID COMPLEX; CALPAIN CALPASTATIN COMPLEX; CALPASTATIN; PD 150606; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALCIUM BINDING; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0037453230     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00274-2     Document Type: Article

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