DNA double-strand breaks, chromosomal rearrangements, and genomic instability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 404, Issue 1-2, 1998, Pages 125-128

  Morgan, William F ^a,b   Corcoran, James ^a   Hartmann, Andreas ^a   Kaplan, Mark I ^a   Limoli, Charles L ^a   Ponnaiya, Brian ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Chromosomal rearrangement; DNA double strand break; Genomic instability

Indexed keywords

BLEOMYCIN; RESTRICTION ENDONUCLEASE; ZINOSTATIN;

ANIMAL CELL; CHO CELL; CHROMOSOME REARRANGEMENT; CONFERENCE PAPER; DNA REPAIR; DNA STRAND BREAKAGE; GENETIC STABILITY; GENOME; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; X RAY;

NON-PROGRAMMATIC;

ANIMALS; CHO CELLS; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CRICETINAE; DNA; DNA DAMAGE; DNA REPAIR; DNA RESTRICTION ENZYMES; MAMMALS;

ANIMALIA; MAMMALIA;

EID: 0032480030     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00104-3     Document Type: Conference Paper

References (14)

1. [1] A.T. Natarajan, G. Obe, A.A.V. Zeeland, F. Palitti, M. Meijers, E.A.M. Verdegaal-Immerzeel, Molecular mechanisms involved in the production of chromosomal aberrations: II. Utilization of Neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle, Mutat. Res. 69 (1980) 293-305.
2. [2] P.E. Bryant, Use of restriction endonucleases to study relationships between DNA double-strand breaks, chromosomal aberrations and other end-points in mammalian cells, Int. J. Radiat. Biol. 54 (1988) 869-890.
3. [3] W.F. Morgan, R.A. Winegar, The use of restriction endonucleases to study the mechanisms of chromosome damage, in: G. Obe, A.T. Natarajan (Eds.), Chromosomal Aberrations: Basic and Applied Aspects, Springer, Berlin, 1990, pp. 70-78.
4. [4] G. Obe, C. Johannes, D. Schulte-Frohlinde, DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation, Mutagenesis 7 (1992) 3-12.
5. [5] D.D. Ager, J.W. Phillips, E.A. Columna, R.A. Winegar, W.F. Morgan, Analysis of restriction enzyme-induced DNA double strand breaks in Chinese hamster ovary cells by pulsed-field gel electrophoresis: implications for chromosome damage, Radiat. Res. 128 (1991) 150-156.
6. [6] J.W. Phillips, W.F. Morgan, Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome, Mol. Cell. Biol. 14 (1994) 5794-5803.
7. [7] P. Wang, R.H. Zhou, C.K. Jackson-Cook, L.H. Povirk, Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 12018-12023.
8. [8] W.F. Morgan, J.P. Day, M.I. Kaplan, E.M. McGhee, C.L. Limoli, Genomic instability induced by ionizing radiation, Radiat. Res. 146 (1996) 247-258.
9. [9] C.L. Limoli, M.I. Kaplan, J.W. Phillips, G.M. Adair, W.F. Morgan, Differential induction of chromosomal instability by DNA strand-breaking agents, Cancer Res. 57 (1997) 4048-4056.
10. [10] B.A. Marder, W.F. Morgan, Delayed chromosomal instability induced by DNA damage, Mol. Cell. Biol. 13 (1993) 6667-6677.
11. [11] C.L. Limoli, J.P. Day, W.F. Ward, W.F. Morgan, Induction of chromosome aberrations and delayed genomic instability by photochemical processes, Photochem. Photobiol. 67 (1998) 233-238.
12. [12] G. Iliakis, The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells, BioEssays 13 (1991) 641-648.
13. [13] M.I. Kaplan, W.F. Morgan, The nucleus is the target for radiation-induced chromosomal instability, Radiat. Res., 1998, submitted.
14. [14] W.P. Chang, J.B. Little, Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells, Radiat. Res. 131 (1992) 53-59.