A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses

Journal of Immunology

Volumn 170, Issue 8, 2003, Pages 3994-4001

  Naumov, Yuri N ^a   Naumova, Elena N ^b   Hogan, Kevin T ^c   Selin, Liisa K ^a   Gorski, Jack ^d  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; CELL POPULATION; CELLULAR DISTRIBUTION; CLONAL VARIATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SEQUENCE; GENE FREQUENCY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MEMORY CELL; MOLECULAR CLONING; PRIORITY JOURNAL; RNA ISOLATION; SEQUENCE ANALYSIS;

EID: 0037446522     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.8.3994     Document Type: Article

References (27)

1. Goldrath, A. W., and M. J. Bevan. 1999. Selecting and maintaining a diverse T-cell repertoire, Nature 402:255.
2. Bousso, P., A. Casrouge, J. D. Altman, M. Haury, J. P. Kanellopoulos, J. P. Abastado, and P. Kourilsky. 1998. Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires. Immunity 9:169.
3. Sourdive, D. J., K. Murali-Krishna, J. D. Altman, A. J. Zajac, J. K. Whitmire, C. Pannetier, P. Kourilsky, B. Evavold, A. Sette, and R. Ahmed. 1998. Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188:71.
4. Lin, M. Y., and R. M. Welsh. 1998. Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice. J. Exp. Med. 11:1993.
5. Walker, P. R., A. Wilson, P. Bucher, and J. L. Maryanski. 1996. Memory TCR repertoires analyzed long-term reflect those selected during the primary response. Int. Immunol. 8:1131.
6. Selin, L. K., M. Y. Lin, K. A. Kraemer, D. M. Pardoll, J. P. Schneck, S. M. Varga, P. A. Santolucito, A. K. Pinto, and R. M. Welsh. 1999. Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. Immunity 11:733.
7. Savage, P. A., J. J. Boniface, and M. M. Davis. 1999. A kinetic basis for T cell receptor repertoire selection during immune response. Immunity 10:485.
8. McHeyzer-Williams, M. G., and M. M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science 268:106.
9. Maryanski, J. L., C. V. Jongeneel, P. Bucher, J.-L. Casanova, and P. R. Walker, 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 4:47.
10. Naumov, Y. N., K. T. Hogan, E. N. Naumova, J. T. Pagel, and J. Gorski. 1998. A class I MHC-restricted recall response to viral peptide is highly polyclonal despite stringent CDR3 selection: implications for establishing memory T cell repertoires in "real-world" conditions. J. Immunol. 160:2842.
11. Moss, P. A., R. J. Moots, W. M. Rosenberg, S. J. Rowland-Jones, H. C. Bodmer, A. J. McMichael, and J. I. Bell. 1991. Extensive conservation of α and β chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc. Natl. Acad. Sci. USA 88:8987.
12. Lehner, P. J., E. C. Wang, P. A. Moss, S. Williams, K. Platt, S. M. Friedman, J. I. Bell, and L. K. Borysiewicz. 1995. Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the Vβ 17 gene segment. J. Exp. Med. 181:79.
13. Altman, J. D., P. A. Moss, P. J. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypical analysis of antigenspecific T lymphocytes. Science 274:94.
14. Hoffmann, T. K., V. S. Donnenberg, U. Friebe-Hoffman, E. M. Meyer, C. R. Rinaldo, A. B. DeLeo, T. L. Whiteside, and A. D. Donnenberg. 2000. Competition of peptide-MHC class I tetrameric complexes with anti-CD3 provides evidence for specificity of peptide binding to the TCR complex. Cytometry 41:321.
15. Dunbar, P. R., G. S. Ogg, J. Chen, N. Rust, P. van der Bruggen, and V. Cerundolo. 1998. Direct isolation, phenotyping and cloning low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood. Curr. Biol. 8:413.
16. Teng, J. M., and K. T. Hogan. 1994. Residues outside of the HLA-A2 peptide-binding groove can abrogate or enhance recognition of influenza virus matrix peptide pulsed cells by cytotoxic T lymphocytes. Mol. Immunol. 31:445.
17. Selin, L. K., S. R. Nahill, and R. M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179:1933.
18. Schroeder, M. 1991. In Fractals, Chaos, Power Laws. Freeman and Co., San Francisco, p. 103-119.
19. Dobzhansky, T., F. Ayala, G. L. Stebbins, Jr., and J. Valentine. 1977. In Evolution. Freeman and Co., San Francisco, p. 132.
20. Freitas, A., and B. Rocha. 2000. Population biology of lymphocytes: the flight for survival. Annu. Rev. Immunol. 18:83.
21. +CD28-regulatory T cells. J. Immunol. 161:5193.
22. Albert, R., H. Jeong, and A. L. Barabasi. 2000. Error and attack tolerance of complex networks. Nature 406:378.
23. Davenport, M. P., C. Fazou, A. J. McMichael, and M. F. C. Callan. 2002. Clonal selection, clonal senescence, and clonal succession: the evolution of the T cell response with a persistant virus. J. Immunol. 168:3309.
24. Bousso, P., J. P. Levraud, P. Kourilsky, and J. P. Abastado. 1999. The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones. J. Exp. Med. 189:1591.
25. Pietgen, H.-O., H. Jürgens, and D. Saupe. 1992. In Chaos and Fractals: New Frontiers in Science. Springer-Verlag, New York, p. 188.
26. D. Thompson. 1966. In On Growth and Form. Abridged Ed. Cambridge Univ. Press, Cambridge, p. 186.
27. Liebovitch, L. S., and D. Scheurle. 2000. Two lessons from fractals and chaos. Complexity 5:34.