LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

Human Molecular Genetics

Volumn 10, Issue 25, 2001, Pages 2869-2877

  Smith, Darrin P ^a   Rayter, Sydonia I ^a   Niederlander, Christiane ^a   Spicer, James ^a   Jones, C Mike ^a   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CYTOPLASM PROTEIN; LEUCINE; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CANCER SUSCEPTIBILITY; CELLULAR DISTRIBUTION; CHROMOSOME 2Q; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; HUMAN; HUMAN CELL; JUVENILE POLYP; NONHUMAN; NUCLEOTIDE SEQUENCE; PEUTZ JEGHERS SYNDROME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; XENOPUS;

ANIMALIA;

EID: 0035660222     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.25.2869     Document Type: Article

References (42)

1. On a very remarkable case of familial polyposis of the mucous membrane of the intestinal tract and nasopharynx accompanied by peculiar pigmentation of the skin and mucous membrane
2. Generalised intestinal polyposis and melanin spots of the oral mucosa, lips and digits: A syndrome of diagnostic significance
3. Cancer and the Peutz-Jeghers syndrome
4. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
5. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
6. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
7. No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas
8. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
9. Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos
10. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome and evidence for allelic and locus heterogeneity
11. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer
12. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
13. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase
14. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
15. Ras-Raf interaction: Two-hybrid analysis
16. Functional annotation of a full-length mouse cDNA collection
17. Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays
18. A gene map of the human genome
19. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36
20. The leucine-rich repeat: A versatile binding motif
21. Imidazoline receptor antisera-selected cDNA clone and mRNA distribution
22. Nischarin, a novel protein that interacts with the integrin α5 subunit and inhibits cell migration
23. From mouse to frogs: Identification and functional analyses of genes required for induction and patterning of the mesoderm
24. FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo
25. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
26. A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map
27. Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors
28. CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer
29. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
30. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
31. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
32. Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
33. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
34. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
35. TGFβ signaling in growth control, cancer and heritable disorders
36. Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer
37. Injected Wnt RNA induces a complete body axis in Xenopus embryos
38. Mutations in the SMAD4/DPC4 gene in juvenile polyposis
39. Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium
40. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
41. RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc and the SH2 domain of Grb2
42. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction