Alloantigen presentation to naive CD8+ T cells by mouse microglia: Evidence for a distinct phenotype based on expression of surface-associated and soluble costimulatory molecules

GLIA

Volumn 18, Issue 2, 1996, Pages 118-128

  Askew, David ^a   Walker, William S ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

CD80; CD86; IL 1 ; IL 12; IL 6; TNF

Indexed keywords

ALLOANTIGEN; CYTOKINE; MEMBRANE ANTIGEN; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; C3H MOUSE; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL LINE; CULTURE MEDIUM; FLOW CYTOMETRY; IMMUNOLOGY; MICROGLIA; MIXED LYMPHOCYTE CULTURE; MOUSE; OLIGONUCLEOTIDE PROBE; PHENOTYPE; POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CULTURE MEDIA; CYTOKINES; FLOW CYTOMETRY; ISOANTIGENS; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICROGLIA; OLIGONUCLEOTIDE PROBES; PHENOTYPE; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS;

EID: 0030267205     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199610)18:2<118::AID-GLIA4>3.0.CO;2-X     Document Type: Article

References (39)

1. Ausiello, C.M., Maleci, A., and Cassone, A. (1992) Modulation of immune function by glioma. Immunol. Today, 13:148-149.
2. Banati, R.B., Gehrmann, J., Schubert, P., and Kreutzberg, G.W. (1993) Cytotoxicity of microglia. Glia, 7:111-118.
3. Benveniste, E.N. (1992) Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action. Am. J. Physiol. Cell Physiol., 263:C1-C16.
4. Bluestone, J.A. (1995) New perspectives of CD28-B7-mediated T cell costimulation. Immunity, 2:555-559.
5. Burakoff, S.J. and Lafferty, K.J. (1993) Antigen, co-stimulators and cytokines: Regulators of allogeneic interactions. Curr. Opin. Immunol., 5:745-746.
6. + T lymphocytes in the central nervous system. Clin. Exp. Immunol., 98:313-318.
7. Cash, E., Zhang, Y., and Rott, O. (1993) Microglia present myelin antigens to T cells after phagocytosis of oligodendrocytes. Cell. Immunol., 147:129-138.
8. De Simone, R., Giampaolo, A., Giometto, B., Gallo, P., Levi, G., Peschle, C., and Aloisi, F. (1995) The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J. Neuropathol. Exp. Neurol., 54:175-187.
9. + T cells compared. J. Immunol., 154:4309-4321.
10. Gehrmann, J., Banati, R.B., Kreutzberg, G.W. (1993) Microglia in the immune surveillance of the brain: Human microglia constitutively express HLA-DR molecules. J. Neuroimmunol., 48:189-198.
11. Goetzl, E.J. and Sreedharan, S.P. (1992) Mediators of communication and adaptation in the neuroendocrine and immune systems. FASEB J., 6:2646-2652.
12. Guerder, S. and Flavell, R.A. (1995) Two for T. Curr. Biol., 5:866-868.
13. Hendrzak, J.A., Wallace, P.K., and Morahan, P.S. (1994) Optimizing the detection of surface antigens on elicited or activated mouse macrophages. Cytometry, 17:349-356.
14. Hickey, W.F. and Kimura, H. (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science, 239:290-292.
15. Kündig, T.M., Hengartner, H., and Zinkernagel, R.M. (1993) T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs. J. Immunol., 150:2316-2321.
16. Lafferty, K.J., Andrus, L., and Prowse, S.J. (1980) Role of lymphokines and antigen in the control of specific T cell responses. Immunol. Rev., 51:279-314.
17. Lampson, L.A. (1987) Molecular bases of the immune response to neural antigens. Trends Neurosci., 10:211-216.
18. Locksley, R.M. (1993) Interleukin 12 in host defense against microbial pathogens. Proc. Natl. Acad. Sci. USA, 90:5879-5880.
19. + T cells. J. Immunol., 147:421-427.
20. + T cell-derived IFN-gamma defines the alloantigen-presenting phenotype. J. Immunol., 151:5218-5227.
21. Merrill, J.E. and Jonakait, G.M. (1995) Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease. FASEB J., 9:611-618.
22. Moore, S.C., McCormack, J.M., Armendariz, E., Gatewood, J., and Walker, W.S. (1992) Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain. J. Neuroimmunol., 41:203-214.
23. Murphy, E., Hieny, S., Sher, A., and O'Garra, A. (1993) Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice. J. Immunol Methods, 162:211-223.
24. Oldstone, M.B.A. and Rall, G.F. (1993) Mechanism and consequence of viral persistence in cells of the immune system and neurons. Intervirology, 35:116-121.
25. Olivas, E., Chen, B.B.D.-M., and Walker, W.S. (1995) Use of the Pannell-Milstein roller bottle apparatus to produce high concentrations of the CSF-1, the mouse macrophage growth factor. J. Immunol Methods, 182:73-79.
26. Perry, V.H. and Andersson, P.-B. (1992) The inflammatory response in the CNS. Neuropathol. Appl. Neurobiol., 18:454-459.
27. Renauld, J., Vink, A., and Van Snick, J. (1989) Accessory signals in murine cytolytic T cell responses: Dual requirement for IL-1 and IL-6. J. Immunol., 143:1894-1898.
28. Shalaby, M.R., Espevik, T., Rice, G.C., Ammann, A.J., Figari, I.S., Ranges, G.E., and Palladino, Jr. (1988) The involvement of human tumor necrosis factors-alpha and -beta in the mixed leukocyte reaction. J. Immunol., 141:499-503.
29. h1 cells. Int. Immunol., 7:1779-1786.
30. + primary T helper cells: Role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation. Int. Immunol., 4:327-335.
31. Theele, D.P. and Streit, W.J. (1993) A chronicle of microglial ontogeny. Glia, 7:5-8.
32. Thompson, C.B. (1995) Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell, 81:979-982.
33. Tivol, E.A., Borriello, A., Schweitzer, N., Lynch, W.P., Bluestone, J.A., and Sharpe, A.H. (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity., 3:541-547.
34. Trinchieri, G. (1995) Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol., 13:251-276.
35. Vilcek, J. and Le, J. (1991) Immunology of cytokines: An introduction. In: The Cytokine Handbook. A. Thomson, ed. Academic Press, San Diego, pp. 1-17.
36. + T cells. J. Neuroimmunol., 63:163-174.
37. Williams, K., Ulvestad, E., and Antel, J.P. (1994) B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol., 24:3031-3037.
38. Windhagen, A., Newcombe, J., Dangond, F., Strand, C., Woodroofe, M.N., Cuzner, M.L., and Hafler, D.A. (1995) Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med., 182:1985-1996.
39. Yanagida, T., Kato, T., Igarashi, O., Inoue, T, and Nariuchi, H. (1994) Second signal activity of IL-12 on the proliferation and IL-2 Rexpression of T helper cell-1 clone. J. Immunol., 152:4919-4928.