Okadaic acid, a protein phosphatase inhibitor, stimulates the activity of Na+/H+ and Na+-independent Cl-/HCO3- exchangers in human lymphocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 1, 2002, Pages 74-81

  De La Rosa, L ^a   Vilarino N ^a   Vieytes, M ^a   Botana, L ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Lymphocytes; Na+ independent Cl HCO3 exchanger; Na+ H+ exchanger; Na+ HCO3 cotransporter; Okadaic acid; PHi regulation

Indexed keywords

AMILORIDE; BICARBONATE; CARBON DIOXIDE; FLUORESCEIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTON; SODIUM ION; SULFONIC ACID DERIVATIVE;

ANION EXCHANGE; ARTICLE; BLOOD; CELL TRANSPORT; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; LYMPHOCYTE; PH; REGULATORY MECHANISM; STIMULATION;

CHLORIDE-BICARBONATE ANTIPORTERS; ENZYME INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; LYMPHOCYTES; OKADAIC ACID; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 0036137627     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0486-x     Document Type: Article

References (28)

1. + exchanger in rat mast cells: Crosstalks between different kinase pathways
2. 3 exchange in cholangiocytes
3. Intracellular pH regulation in cultured astrocytes from rat hippocampus. 2. Electrogenic Na/HCO3 cotransport
4. + antiport
5. - cotransporter
6. + exchanger are involved in intracellular pH regulation of cultured mature rat cerebellar oligodendrocytes
7. Organic phosphates modulate anion self-exchange across the human erythrocyte membrane
8. Crosstalk between cytosolic pH and intracellular calcium in human lymphocytes. Effect of a-aminopyridin, ammonium chloride and ionomycin
9. 3 transporter in human lymphocytes
10. Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells
11. - exchange
12. - cotransport
13. + exchange in lymphocytes by phorbol esters: Change in cytoplasmic pH dependence of the antiport
14. 3 exchange in NIH-3T3 fibroblasts
15. Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte
16. - exchanger activity in human fibroblasts
17. 3 exchange to Na-H antiport in lymphocytes
18. - exchange by stimulation of acid secretion in the parietal cell
19. + exchanger isoforms
20. Src-family tyrosine kinase regulates intracellular pH in cardiomyocytes
21. Regulation of intracellular pH in the spontaneously hypertensive rat. Role of bicarbonate-dependent transporters
22. - cotrans-porters: Cloning and physiology
23. + exchanger, NHE-1, by phosphorylating a set of common sites
24. - exchange in patients with chronic renal failure: Correlation with renal function
25. Intra-cellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ
26. 3(-) ex-changer in spontaneous thymocyte apoptosis
27. --dependent alkalinizing mechanism
28. + exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation