Phosphatidylethanolamine mediated destabilization of lipid-based pDNA delivery systems

International Journal of Pharmaceutics

Volumn 255, Issue 1-2, 2003, Pages 117-127

  Wong, F M P ^a,b,c   Harvie, P ^a,d   Zhang, Y P ^a,c   Ramsay, E C ^a   Bally, M B ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ALZA CORPORATION   (United States)

^d Targeted Genetics Corporation   (United States)

Author keywords

Gene transfer; Headgroup interactions; Lipid DNA particles; Non viral gene therapy; Phosphatidylethanolamine; Plasmid DNA

Indexed keywords

1,2 DILAUROYLGLYCERO 3 PHOSPHOETHANOLAMINE; 1,2 DIMYRISTOYLGLYCEROL 3 PHOSPHOETHANOLAMINE; 1,2 DIOLEOYLGLYCERO 3 PHOSPHOETHANOLAMINE; 1,2 DISTEAROYLGLYCERO 3 PHOSPHOETHANOLAMINE; AMPHOLYTE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIOLEOYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLCHOLINE; DNA; FLUORESCENT DYE; LIPID; N N DIOLEOYL N,N DIMETHYLAMMONIUM CHLORIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; TO PRO 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; FEMALE; FLUORESCENCE; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; IN VIVO STUDY; MELANOMA CELL; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; TUMOR MODEL;

EID: 0037436945     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00051-6     Document Type: Article

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