Pathological excretion patterns of urinary proteins in renal cell cancer patients exposed to trichloroethylene

Occupational Medicine

Volumn 49, Issue 5, 1999, Pages 299-305

  Bruning T ^b   Mann, H ^c   Melzer, H ^c   Sundberg, A G M ^a   Bolt, H M ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^c NONE

Author keywords

Nephrotoxicity; Renal cell cancer; SDS PAGE; Trichoroethylene; 1 microglobulin

Indexed keywords

ALPHA 1 MICROGLOBULIN; PROTEIN; TRICHLOROETHYLENE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; KIDNEY CARCINOMA; KIDNEY TUBULE; MALE; NEPHROTOXICITY; OCCUPATIONAL EXPOSURE; PERIODIC MEDICAL EXAMINATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN URINE LEVEL;

EID: 18744437410     PISSN: 09627480     EISSN: None     Source Type: Journal    
DOI: 10.1093/occmed/49.5.299     Document Type: Article

References (29)

1. Brogren C-H, Christensen JM, Rasmussen K. Occupational exposure to chlorinated organic solvents and its effect on the renal excretion of N-acetyl-beta-D-glucosaminidase. Arch Toxicol 1986; Suppl 9: 460-464.
2. Maltoni C, Lefemine G, Cotti G, Perino G. Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague Dawley rats and Swiss and B6C3F1 mice. Ann NY Acad Sci 1988; 534: 316-342.
3. National Toxicology Program. Carcinogenesis studies of trichloroethylene (without epichlohydrin) in F344/N rats and B6C3F1 mice (gavage studies). Technical report 243. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health and Human Services.
4. IARC. Trichloroethylene. In: IARC Monographs 1995; 63: 75-158.
5. Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene. Arch Toxicol 1995; 69: 291-299.
6. Vamvakas S, Brüning T, Thomasson B, et al. Renal cell cancer correlated with occupational exposure to trichlorethene. J Cancer Res Clin Oncol 1998; 124: 374-382.
7. Goeptar AR, Commandeur JNM, van Ommen B, van Bladeren PJ, Vermeulen NPE. Metabolism and kinetics of trichloroethylene in relation to carcinogenicity. Relevance of the mercapturic acid pathway. Chem Res Toxicol 1995; 8: 3-21.
8. Filser JG, Bolt HM. Pharmacokinetics of halogenated ethylenes in rats. Arch Toxicol 1979; 42: 123-136.
9. Birner G, Vamvakas S, Dekant W, Henschler D. The nephrotoxic and genotoxic N-acetyl-S-dichlorvinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroetene exposure in humans. Environ Health Persp 1993; 99: 281-284.
10. Bernauer U, Birner G, Dekant W, Henschler D. Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation. Arch Toxicol 1996; 70: 338-346.
11. Davis J, Blakeman D, Jolly E, Packwood W, Kolaya G, PetryT. S-(1,2-Dichlorovinyl)-L-cysteine-induced nephrotoxicity in the New Zealand White rabbit. Characterisation of proteinuria and examination of the potential role of oxidative injury. Toxicol Pathol 1995; 23: 487-497.
12. Vamvakas S, Elfarra AA, Dekant W, Henschler D, Anders MW. Mutagenicity of amino acid and glutathione S-conjugates in the Ames test. Mutat Res 1988, 206: 83-90.
13. Brüning T, Golka K, Makropoulos V, Bolt HM. Pre-existence of chronic tubular damage in cases of renal cell cancer after long and high exposure to trichloroethylene. Arch Toxicol 1996; 70: 259-260.
14. Brüning T, Weirich G, Hornauer MA, Höfler H, Brauch H. Renal cell carcinoma in trichloroethene (TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumor suppressor gene. Arch Toxicol 1997; 71: 332-335.
15. DFG. Trichlorethen. In: Greim H, Henschler D, eds. Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. Weinheim: VCH-Verlagsgesellschaft, 1996.
16. Mann H, Melzer H, Kierdorf H. Hochauflösende SDS-Polyacrylamid-gradientengel-Elektrophorese (SDS-PAGE) der Urinproteine mit dem Phast-System und Laser-densitometrie. Nieren-und Hochdruckkrankheiten 1995; 24: 259-263.
17. Bazzi C, Petrini C, Rizza V, Arrigo G, Beltrame A, D'Amico G. Characterization of proteinuria in primary glomerulonephritides. SDS-PAGE patterns: Clinical significance and prognostic value of low molecular weight ('tubular') proteins. Am J Kidney Dis 1997; 29: 27-35.
18. Kierdorf H, Melzer H, Mann H, Siebert H. Differentiation of proteins in polyacrylamide gels by a modification of silver staining for the Phast System and a laser densiometer. Electrophoresis 1993; 14: 820-822.
19. Heinegard D, Tiderström G. Determination of serum creatinine by a direct colorimetric method. Clin Chim Acta 1973; 43: 305-310.
20. Müller M, Birner G, Henschler D, Dekant W. Structures of DNA adducts formed from haloketenes and halothioketenes: a study to identify possible adducts formed from trichloro- and perchloroethene through bioactivation of glutathione conjugation. IARC Publ 1994; 115: 423-428.
21. Green T, Dow J, Foster JR, Hext PM. Formic acid excretion in rats exposed to trichloroethylene: a possible explanation for renal toxicity in long-term studies. Toxicology 1998; 127: 39-47.
22. Golka K, Hartert-Raulf T, Schöps W, Kierfeld G, Brüning T, Bolt HM. Subclinical changes in urinary protein excretion of renal cell cancer patients: effect of high occupational exposure to trichloroethylene. Central Eur J Occup Environ Med 1997; 3: 167-174.
23. Oberle G, Neumann HPH, Schollmeyer P, Boesken WH, Stahl RAK. Mild proteinuria in patients with unilateral kidney. Klin Wochenschr 1985; 63: 1048-1051.
24. McLaughlin JK, Blot WJ, Fraumeni JF Jr. Diuretics and renal cell cancer. J Nat Cancer Inst 1988; 80: 378.
25. Wolk A, Lindblad P, Adami H-O. Nutrition and renal cell cancer. Cancer Causes Control 1996; 7: 5-18.
26. Adamson RH. Mutagens and carcinogens formed during cooking of foods and methods to minimize their formation In: De Vita VG Jr, Hellman S, Rosenberg SA, eds. Cancer prevention. Philadelphia, PA (USA): Lippincott, 1990: 1-7.
27. van Ypersele de Strihou C, Vanherweghem JL. The tragic paradigm of Chinese herbs nephropathy. Nephrol Dial Transplant 1995; 157-160.
28. Raicevic S, Trnacevic S, Hranisavljevic J, Vucelic D. Renal function, protein excretion, and pathology of Balkan endemic nephropathy. II. Protein excretion. Kidney Int 1991; 40(Suppl 34): S52-S56.
29. Goldberg M. Balkan nephropathy. In: Wijngaarden JB, Smith LH Jr., eds. Cecil Textbook of Medicine. London, UK: Saunders, 1985: 590.