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12
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0035935194
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See for example (a) Hagmann W.K., Durette P.L., Lanza T., Kevin N.J., de Laszlo S.E., Kopka I.E., Young D., Magriotis P.A., Li B., Lin L.S., Yang G., Kamenecka T., Chang L.L., Wilson J., MacCoss M., Mills S.G., Van Riper G., McCauley E., Egger L.A., Kidambi U., Lyons K., Vincent S., Stearns R., Colletti A., Teffera J., Tong S., Fenyk-Melody J., Owens K., Levorse D., Kim P., Schmidt J.A., Mumford R.A. Bioorg. Med. Chem. Lett. 11:2001;2709. (b) Chen L., Trilles R., Miklowski D., Huang T.-L., Fry D., Campbell R., Rowan K., Schwinge V., Tilley J.W. Bioorg. Med. Chem. Lett. 12:2002;1679.
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Lanza, T.3
Kevin, N.J.4
De Laszlo, S.E.5
Kopka, I.E.6
Young, D.7
Magriotis, P.A.8
Li, B.9
Lin, L.S.10
Yang, G.11
Kamenecka, T.12
Chang, L.L.13
Wilson, J.14
MacCoss, M.15
Mills, S.G.16
Van Riper, G.17
McCauley, E.18
Egger, L.A.19
Kidambi, U.20
Lyons, K.21
Vincent, S.22
Stearns, R.23
Colletti, A.24
Teffera, J.25
Tong, S.26
Fenyk-Melody, J.27
Owens, K.28
Levorse, D.29
Kim, P.30
Schmidt, J.A.31
Mumford, R.A.32
more..
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13
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0037124203
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See for example (a) Hagmann W.K., Durette P.L., Lanza T., Kevin N.J., de Laszlo S.E., Kopka I.E., Young D., Magriotis P.A., Li B., Lin L.S., Yang G., Kamenecka T., Chang L.L., Wilson J., MacCoss M., Mills S.G., Van Riper G., McCauley E., Egger L.A., Kidambi U., Lyons K., Vincent S., Stearns R., Colletti A., Teffera J., Tong S., Fenyk-Melody J., Owens K., Levorse D., Kim P., Schmidt J.A., Mumford R.A. Bioorg. Med. Chem. Lett. 11:2001;2709. (b) Chen L., Trilles R., Miklowski D., Huang T.-L., Fry D., Campbell R., Rowan K., Schwinge V., Tilley J.W. Bioorg. Med. Chem. Lett. 12:2002;1679.
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Chen, L.1
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Fry, D.5
Campbell, R.6
Rowan, K.7
Schwinge, V.8
Tilley, J.W.9
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15
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84994398359
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note
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2, 0.1% Tween. After incubation for 2 h at room temperature the plates were washed and residual VCAM visualised with peroxidase coupled anti-human Fc.
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16
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84994390844
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note
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A Jurkat cell line expressing VLA4 was incubated at 37°C for 30 min with human 2-domain VCAM-1-FC immobilised on a plate with anti-human FC in the presence of the test compounds. The plates were washed and residual cells were stained with Rose Bengal.
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17
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84994444230
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note
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1H resonances are resolved at 7.31 ppm (major) and 7.40 ppm (minor). In the NOESY data no crosspeaks are observed corresponding to these resonances. Weak, positively phased nOe crosspeaks are observed between the two NH resonances in each conformer at 9.39 ppm (major) and 9.66 ppm (minor) and the higher frequency phenylalanine AA′BB′ multiplet resonance centred at 7.67 ppm. This identifies 5 as the Z isomer. Parallel data was recorded for the other isomeric pairs of molecules.
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18
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18344390406
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Porter J.R., Archibald S.C., Childs K., Critchley D., Head J.C., Linsley J., Parton T.A.H., Robinson M.K., Shock A., Taylor R.J., Warrellow G.J., Alexander R., Langham B. Bioorg. Med. Chem. Lett. 12:2002;1051.
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Bioorg. Med. Chem. Lett.
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Porter, J.R.1
Archibald, S.C.2
Childs, K.3
Critchley, D.4
Head, J.C.5
Linsley, J.6
Parton, T.A.H.7
Robinson, M.K.8
Shock, A.9
Taylor, R.J.10
Warrellow, G.J.11
Alexander, R.12
Langham, B.13
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