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Volumn 13, Issue 5, 2003, Pages 805-808

Dehydrophenylalanine derivatives as VLA-4 integrin antagonists

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BLOCKING AGENT; CD29 ANTIGEN ANTAGONIST; INTEGRIN; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0037430541     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00019-2     Document Type: Article
Times cited : (9)

References (19)
  • 1
    • 0013437623 scopus 로고
    • Hynes R. Cell. 48:1987;554.
    • (1987) Cell , vol.48 , pp. 554
    • Hynes, R.1
  • 13
    • 0037124203 scopus 로고    scopus 로고
    • See for example (a) Hagmann W.K., Durette P.L., Lanza T., Kevin N.J., de Laszlo S.E., Kopka I.E., Young D., Magriotis P.A., Li B., Lin L.S., Yang G., Kamenecka T., Chang L.L., Wilson J., MacCoss M., Mills S.G., Van Riper G., McCauley E., Egger L.A., Kidambi U., Lyons K., Vincent S., Stearns R., Colletti A., Teffera J., Tong S., Fenyk-Melody J., Owens K., Levorse D., Kim P., Schmidt J.A., Mumford R.A. Bioorg. Med. Chem. Lett. 11:2001;2709. (b) Chen L., Trilles R., Miklowski D., Huang T.-L., Fry D., Campbell R., Rowan K., Schwinge V., Tilley J.W. Bioorg. Med. Chem. Lett. 12:2002;1679.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 1679
    • Chen, L.1    Trilles, R.2    Miklowski, D.3    Huang, T.-L.4    Fry, D.5    Campbell, R.6    Rowan, K.7    Schwinge, V.8    Tilley, J.W.9
  • 15
    • 84994398359 scopus 로고    scopus 로고
    • note
    • 2, 0.1% Tween. After incubation for 2 h at room temperature the plates were washed and residual VCAM visualised with peroxidase coupled anti-human Fc.
  • 16
    • 84994390844 scopus 로고    scopus 로고
    • note
    • A Jurkat cell line expressing VLA4 was incubated at 37°C for 30 min with human 2-domain VCAM-1-FC immobilised on a plate with anti-human FC in the presence of the test compounds. The plates were washed and residual cells were stained with Rose Bengal.
  • 17
    • 84994444230 scopus 로고    scopus 로고
    • note
    • 1H resonances are resolved at 7.31 ppm (major) and 7.40 ppm (minor). In the NOESY data no crosspeaks are observed corresponding to these resonances. Weak, positively phased nOe crosspeaks are observed between the two NH resonances in each conformer at 9.39 ppm (major) and 9.66 ppm (minor) and the higher frequency phenylalanine AA′BB′ multiplet resonance centred at 7.67 ppm. This identifies 5 as the Z isomer. Parallel data was recorded for the other isomeric pairs of molecules.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.