Chemical genetics goes (zebra) fishing

Angewandte Chemie - International Edition

Volumn 42, Issue 10, 2003, Pages 1086-1087

  Breinbauer, Rolf ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Assays; Biological chemistry; Combinatorial chemistry; High throughput screening

Indexed keywords

ANIMAL CELL CULTURE; FISHERIES; GENETIC ENGINEERING;

ZEBRA FISH;

BIOCHEMICAL ENGINEERING;

CHEMICAL GENETICS; COMBINATORIAL LIBRARY; GENETIC SCREENING; MOLECULAR PROBE; NONHUMAN; PHENOTYPE; POINT MUTATION; SHORT SURVEY; ZEBRA FISH;

ACRYLAMIDES; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; LARVA; MOLECULAR STRUCTURE; OVUM; POLYCYCLIC HYDROCARBONS, AROMATIC; PYRIMIDINES; THIONES; ZEBRAFISH;

EID: 0037429857     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200390289     Document Type: Short Survey

References (21)

1. R. Capdeville, E. Buchdunger, J. Zimmermann, A. Matter, Nat. Rev. Drug Discovery 2002, 1, 493-502.
2. a) T. J. Mitchison, Chem. Biol. 1994, 1, 3-6;
3. b.) S. L. Schreiber, Bioorg. Med. Chem. 1998, 6, 1127-1152;
4. c.) C. M. Crews, U. Splittgerber, Trends Biochem. Sci. 1999, 24, 317-320;
5. d.) B. R. Stockwell, Trends Biotechnol. 2000, 18, 449-455;
6. e.) B. R. Stockwell, Nat. Rev. Genet. 2000, 1, 116-125.
7. For excellent reviews of chemical approaches to study biological systems, see: a) P. J. Alaimo, M. A. Shogren-Knaak, K. M. Shokat, Curr. Opin. Chem. Biol. 2001, 5, 360-367;
8. b.) M. A. Shogren-Knaak, P. J. Alaimo, K. M. Shokat, Annu. Rev. Cell Dev. Biol. 2001, 17, 405-433;
9. c.) K. M. Shokat, M. Vellaca, Drug Discovery Today 2002, 7, 872-879;
10. d.) G. E. Ward, K. L. Carey, N. J. Westwood, Cell. Microbiol. 2002, 4, 471-482.
11. T. U. Mayer, T. M. Kapoor, S. J. Haggarty, R. W. King, S. L. Schreiber, T. J. Mitchison, Science 1999, 286, 971-974.
12. Z. Maliga, T. M. Kapoor, T. J. Mitchison, Chem. Biol. 2002, 9, 989-996.
13. R. T. Peterson, B. A. Link, J. E. Dowling, S. L. Schreiber, Proc. Natl. Acad. Sci. USA 2000, 97, 12965-12969.
14. H.-S. Moon, E. M. Jacobson, S. M. Kheronsky, M. R. Luzung, D. P. Walsh, W. Xiong, J. W. Lee, P. B. Parikh, J. C. Lam, T.-W. Kang, G. R. Rosania, A. F. Schier, Y.-T. Chang, J. Am. Chem. Soc. 2002, 124, 11608-11609.
15. a.) J. P. Briggs, Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002, 282, R3-R9;
16. b.) R. S. Hauptschein, B. K. Eustace, D. G. Jay, Exp. Hematol. 2002, 30, 381-387;
17. c.) E. E. Patton, L. I. Zon, Nat. Genet. 2001, 2, 956-966;
18. d.) C. Nüsslein-Volhard, Angew. Chem. 1996, 108, 2316-2328;
19. e.) Angew. Chem. Int. Ed. Engl. 1996, 35, 2176-2187.
20. R. T. Peterson, J. D. Mably, J.-N. Chen, M. C. Fishman, Chem. Biol. 2001, 11, 1481-1491.
21. For a review of new tools for the identification of biological targets of small molecules, see: R. W. King, Chem. Biol. 1999, 6, R327-R333.