Rapid stimulation of L-arginine transport by D-glucose involves p42/44mapk and nitric oxide in human umbilical vein endothelium

Circulation Research

Volumn 92, Issue 1, 2003, Pages 64-72

  Flores, Carlos ^a   Rojas, Susana ^a   Aguayo, Claudio ^a   Parodi, Jorge ^a   Mann, Giovanni ^b   Pearson, Jeremy D ^b   Casanello, Paola ^a   Sobrevia, Luis ^a  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Arginine; Endothelium; Glucose; Humans; Nitric oxide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE TRIPHOSPHATE; ARGININE; CALCIUM ION; CALPHOSTIN; CITRULLINE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; GLIBENCLAMIDE; GLUCOSE; KT 5823; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL; PROTEIN KINASE C INHIBITOR; PROTEIN P42; PROTEIN P44; SUPEROXIDE DISMUTASE; TRITIUM;

AMINO ACID TRANSPORT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; GLUCOSE INFUSION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HYPERPOLARIZATION; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASODILATATION;

ALPHA-TOCOPHEROL; AMINO ACID TRANSPORT SYSTEMS, BASIC; ARGININE; BIOLOGICAL TRANSPORT; CATIONIC AMINO ACID TRANSPORTER 1; CATIONIC AMINO ACID TRANSPORTER 2; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLUCOSE; HUMANS; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; ONIUM COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN KINASE C; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; UMBILICAL VEINS;

EID: 0037428211     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000048197.78764.D6     Document Type: Article

References (42)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, patho-physiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
2. - and nitric oxide synthase in human endothelial cells association with membrane hyperpolarization. J Physiol (Lond). 1995;489:183-192.
3. -/hCAT-2B, and lower activity of nitric oxide synthase in human umbilical vein endothelial cells. Circ Res. 2002:91:127-134.
4. +) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells. J Physiol (Lond). 1996;490:775-781.
5. Montecinos VP, Aguayo C. Flores C, Wyatt AW, Pearson JD, Mann GE, Sobrevia L. Regulation of adenosine transport by D-glucose in human fetal endothelial cells: involvement of nitric oxide, protein kinase C and mitogen-activated protein kinase. J Physiol (Lond). 2000;529:777-790.
6. Cosentino F, Hishikawa K, Katusic ZS, Lüscher TF. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation. 1997;96:25-28.
7. Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Creager MA. Inhibition of protein kinase Cγ prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res. 2002;90:107-111.
8. Duckrow RB. Decreased cerebral blood flow during acute hyperglycaemia. Brain Res. 1995:703:145-150.
9. Wascher TC, Bachernegg M. Kickenweiz A. Stark G, Stark U, Toplak H, Graier WF. Involvement of the L-arginine-nitric oxide pathway in hyperglycaemia-induced coronary artery dysfunction of isolated guinea pig hearts. Eur J Clin Invest. 1996;26:707-712.
10. Cipolla MJ, Porter JM, Osol G. High glucose concentration dilate cerebral arteries and diminish myogenic tone through an endothelial mechanism. Stroke. 1997;28:405-411.
11. Sobrevia L, Mann GE. Dysfunction of the nitric oxide signalling pathway in diabetes and hyperglycaemia. Exp Physiol. 1997;82:1-30.
12. Pan M, Wasa M, Lind DS, Gertler J, Abbott W, Souba WW. TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. Ann Surg. 1995;221:590-601.
13. Racké K, Hey C, Mörssner J. Hammermann R, Stichnote C, Wessler I. Activation of L-arginine transport by protein kinase C in rabbit, rat and mouse alveolar macrophages. J Physiol (Lond). 1998;551:813-825.
14. Haneda M, Araki S, Togawa M, Sugimoto T, Isono M, Kikkawa R. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Diabetes. 1997:46:847-853.
15. Natarajan R. Scott S, Bai W. Yernerni K, Nadler J. Angiotensin II signalling in vascular smooth muscle cells under high glucose conditions. Hypertension. 1999;33:378-384.
16. Pieper GM. Review of alterations in endothelial nitric oxide production in diabetes. Hypertension. 1998;31:1047-1060.
17. De Vriese AS, Verbeuren TJ, Van de Voorde J. Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963-974,
18. Flores C, Sobrevia L. Acute effect of D-glucose on L-arginine transport and nitric oxide synthesis in human fetal endothelium. J Physiol (Lond). 2000;523:104P. Abstract.
19. Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J. 2000:351:289-305.
20. Grider JR. Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am J Physiol. 1993;264:G334-G340.
21. Kobayashi E, Ando K, Nakano H, Iida T, Ohno H, Morimoto M, Tamaoki T. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C, I: fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989;42:1470-1474.
22. + channels and cyclic GMP as components of vasodilation by nicorandil. Eur J Pharmacol. 1992;29:1-7.
23. Katnik C, Adams DJ. Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells. Am J Physiol. 1997;272:H2507-H2511.
24. Isenovic E, Muniyappa R, Milivojevic N, Rao Y, Sowers JR. Role of P13-kinase in isoproterenol and IGF-1 induced ecNOS activity. Biochem Biophys Res Commun. 2001;285:954-958.
25. Schilling WP. Effect of membrane potential on cytosolic calcium of bovine aortic endothelial cells. Am J Physiol. 1989;257:H778-H784.
26. Misra HP. Adrenochrome assay. In: Greenwald RA, ed. Handbook of Methods for Oxygen Radical Research. Boca Raton, Fla: CRC Press; 1989:237-241.
27. Ganz MB, Seftel A. Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E. Am J Physiol. 2000;278:E146-E152
28. Harper JF. Peritz' F test: BASIC program of a robust multiple comparison test for statistical analysis of all differences among group means. Comput Biol Med. 1984;14:437-445.
29. +L in human fetal endothelial cells. J Physiol (Lond). 1999;517:47P. Abstract.
30. +. Am J Physiol. 2002;282:C134-C143.
31. Devés R, Boyd CAR. Transporters for cationic amino acids in animal cells: discovery, structure and function. Physiol Rev. 1998;78:487-545.
32. Bussolati O, Sala R, Astorri A, Rotoli BM, Dall'Asta V, Gazzola GC. Characterization of amino acid transport in human endothelial cells. Am J Physiol. 1993;265:C1006-C1014.
33. Irie K, Tsukahara F, Fujii E, Uchida Y, Yoshioka T. He WR, Shitashige M, Murota S, Muraki T. Cationic amino acid transporter-2 mRNA induction by tumor necrosis factor-α in vascular endothelial cells. Eur J Pharmacol. 1997;339:289-293.
34. + carrier hCAT-2B. Nitric Oxide. 1997;1:65-73.
35. Nilius B, Droogmans G, Ion channels and their functional role in vascular endothelium. Physiol Rev. 2001;81:1415-1459.
36. Sobey CG. Potassium channel function in vascular disease. Arterioscler Thromb Vasc Biol. 2001;21:28-38.
37. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399:601-605.
38. Shaul PW. Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol. 2002:64:749-774.
39. Bogle RG, Moncada S, Pearson JD, Mann GE. Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter. Br J Pharmacol. 1992;105:768-770.
40. Ogonowski AA, Kaesemeyer WH, Jin L, Ganapathy V, Leibach FH. Caldwell RW. Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production. Am J Physiol. 2000;278:C136-C146.
41. Lal BK, Varma S, Pappas PJ, Hobson RW II, Duran WN. VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc Res. 2001;62:252-262.
42. Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, Granger HJ, Ledda F, Ziche M. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase 1/2 activation in postcapillary endothelium. J Biol Chem. 1998;273:4220-4226.