R-Ras glucosylation and transient RhoA activation determine the cytopathic effect produced by toxin B variants from toxin A-negative strains of Clostridium difficile

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 7956-7963

  Chaves Olarte, Esteban ^a,b,c   Freer, Enrique ^b   Parra, Andrea ^c   Guzmán Verri, Caterina ^a,c   Moreno, Edgardo ^c   Thelestam, Monica ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSIDAD NACIONAL   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CHEMICAL ACTIVATION; DISEASE CONTROL; TOXIC MATERIALS;

CYTOPATHIC EFFECTS;

ENZYMES;

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; EPIDERMAL GROWTH FACTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; RAC1 PROTEIN; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; BACTERIAL PROTEIN; BACTERIAL TOXIN; GUANOSINE TRIPHOSPHATASE; RRAS PROTEIN, MOUSE; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE; TYROSINE;

ARTICLE; BACTERIAL INFECTION; CELL ULTRASTRUCTURE; CLOSTRIDIUM DIFFICILE; CYTOPATHOGENIC EFFECT; DIARRHEA; EXTRACELLULAR MATRIX; FILOPODIUM; GLYCOSYLATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; CELL STRAIN 3T3; ENZYME ACTIVATION; METABOLISM; MOUSE; PATHOGENICITY; PHOSPHORYLATION; SCANNING ELECTRON MICROSCOPY; VIRULENCE;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM DIFFICILE;

3T3 CELLS; ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; ENZYME ACTIVATION; GLYCOSYLATION; GTP PHOSPHOHYDROLASES; MICE; MICROSCOPY, ELECTRON, SCANNING; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RAS PROTEINS; RHOA GTP-BINDING PROTEIN; TYROSINE; VIRULENCE;

EID: 0037424238     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209244200     Document Type: Article

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