A novel single-stranded DNA enzyme expression system using HIV-1 reverse transcriptase

Biochemical and Biophysical Research Communications

Volumn 301, Issue 2, 2003, Pages 535-539

  Kusunoki, Akiko ^a   Miyano Kurosaki, Naoko ^a   Takaku, Hiroshi ^a  

^a CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

DNA enzyme; HIV 1 reverse transcriptase; Primer binding site (PBS); ssDNA expression vector; tRNA (Lys 3)

Indexed keywords

LYSINE; RNA DIRECTED DNA POLYMERASE; SINGLE STRANDED DNA; VIRUS DNA; VIRUS RNA;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA TRANSCRIPTION;

HUMAN IMMUNODEFICIENCY VIRUS 1; VECTORS;

EID: 0037423754     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)03067-X     Document Type: Article

References (24)

1. Goodchild J. Hammerhead ribozymes: biochemical and chemical considerations. Curr. Opin. Mol. Ther. 2:2000;272-281.
2. Lewin A.S., Hauswirth W.W. Ribozyme gene therapy: applications for molecular medicine. Trends Mol. Med. 7:2001;221-228.
3. Shippy R., Lockner R., Farnsworth M., Hampel A. The hairpin ribozyme. Discovery, mechanism, and development for gene therapy. Mol. Biotechnol. 12:1999;117-129.
4. Sun L.Q., Ely J.A., Gerlach W.L., Symonds G. Anti-HIV ribozymes. Mol. Biotechnol. 7:1997;241-251.
5. Symonds R.H. Small catalytic RNAs. Annu. Rev. Biochem. 61:1992;641-671.
6. Vaish N.K., Kore A.R., Eckstein F. Recent developments in the hammerhead ribozyme field. Nucleic Acids Res. 26:1998;5237-5242.
7. Breaker R.R., Joyce G.F. A DNA enzyme that cleaves RNA. Chem. Biol. 1:1994;223-229.
8. 2+ -dependent RNA phosphoesterase activity Chem. Biol. 2:1995;655-660.
9. Breaker R.R. DNA enzymes. Nat. Biotechnol. 15:1997;427-431.
10. Breaker R.R. Catalytic DNA: in training and seeking employment. Nat. Biotechnol. 17:1999;422-423.
11. Geyer C.R., Sen D. Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme. Chem. Biol. 4:1997;579-593.
12. Li Y., Breaker R.B. Deoxyribozymes: new players in the ancient game of biocatalysis. Curr. Opin. Struct. Biol. 9:1999;315-323.
13. Santoro S.W., Joyce G.F. A general purpose RNA-cleaving DNA enzyme. Proc. Natl. Acad. Sci. USA. 94:1997;4262-4266.
14. Sun L.Q., Cairns M.J., Saravolac E.G., Baker A., Gerlach W.L. Catalytic nucleic acids: from lab to applications. Pharmacol. Rev. 52:2000;325-347.
15. Santiago F.S., Lowe H.C., Kavurma M.M., Chesterman C.N., Baker A., Atkins D.G., Khachigian L.M. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat. Med. 11:1999;1264-1269.
16. Zhang X., Xu Y., Ling H., Hattori T. Inhibition of infection of incoming HIV-1 virus by RNA-cleaving DNA enzyme. FEBS Lett. 458:1999;151-156.
17. Sun L.Q., Cairns M.J., Gerlach W.L., Witherington C., Wang L., King A. Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme. J. Biol. Chem. 274:1999;17236-17241.
18. Wu Y., Yu L., McMahon R., Rossi J.J., Forman S.J., Snyder D.S. Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes). Hum Gene Ther. 10:1999;2847-2857.
19. Basu S., Sriram B., Goila R., Banerjea A.C. Targeted cleavage of HIV-1 coreceptor-CXCR-4 by RNA-cleaving DNA-enzyme: inhibition of coreceptor function. Antiviral Res. 46:2000;125-134.
20. Toyoda T., Imamura Y., Takaku H., Kashiwagi T., Hara K., Iwahashi J., Ohtsu Y., Tsumara N., Kato H., Hamada N. Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme. FEBS Lett. 481:2000;113-116.
21. Sriram B., Banerjea A.C. In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression. Biochem. J. 352:2000;667-673.
22. Unwalla H., Banerjea A.C. Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT/Rev RNA. Biochem. J. 357:2001;147-155.
23. Zhang L., Gasper W.J., Stass S.A., Ioffe O.B., Davis M.A., Mixson A.J. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res. 62:2002;5463-5469.
24. Khachigian L.M., Fahmy R.G., Zhang G., Bobryshev Y.V., Kaniaros A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun. J. Biol. Chem. 277:2002;22985-22991.