Kinetoplastid RNA editing ligases: Complex association, characterization, and substrate requirements

Molecular and Biochemical Parasitology

Volumn 127, Issue 2, 2003, Pages 161-167

  Palazzo, Setareh S ^a,b   Panigrahi, Aswini K ^a,b   Igo Jr , Robert P ^a,b   Salavati, Reza ^a,b   Stuart, Kenneth ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Editosome; Kinetoplastid; RNA editing; RNA ligase; Trypanosoma brucei

Indexed keywords

BRIDGED COMPOUND; COMPLEMENTARY RNA; DNA; LIGASE; MESSENGER RNA; MULTIENZYME COMPLEX; RECOMBINANT PROTEIN; RNA;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; TRYPANOSOMA BRUCEI;

KINETOPLASTIDA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0037417236     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00333-X     Document Type: Article

References (23)

1. Stuart K., Allen T.E., Heidmann S., Seiwert S.D. RNA editing in kinetoplastid protozoa. Microbiol. Mol. Biol. Rev. 61:1997;105-120.
2. Estevez A.M., Simpson L. Uridine insertion/deletion RNA editing in trypanosome mitochondria - a review. Gene. 240:1999;247-260.
3. Kable M.L., Heidmann S., Stuart K. RNA editing: getting U into RNA. Trends Biochem. Sci. 22:1997;162-166.
4. Stuart K, Panigrahi AK, Salavati R. RNA editing in kinetoplastid mitochondria. In: Bass BL, editor. RNA editing: frontiers in molecular biology, vol. 1. Oxford: Oxford University Press; 2000. p. 1-19.
5. White T.C., Borst P. RNA end-labeling and RNA ligase activities can produce a circular rRNA in whole cell extracts from trypanosomes. Nucleic Acid Res. 15:1987;3275-3290.
6. Bakalara N., Simpson A.M., Simpson L. The Leishmania kinetoplast-mitochondrion contains terminal uridylyltransferase and RNA ligase activities. J. Biol. Chem. 264:1989;18679-18686.
7. Sabatini R., Hajduk S.L. RNA ligase and its involvement in guide RNA/mRNA chimera formation. Evidence for a cleavage-ligation mechanism of Trypanosoma brucei mRNA editing. J. Biol. Chem. 270:1995;7233-7240.
8. Rusché L.N., Cruz-Reyes J., Piller K.J., Sollner-Webb B. Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria. EMBO J. 16:1997;4069-4081.
9. Panigrahi A.K., Gygi S., Ernst N., Igo R.P. Jr., Palazzo S.S., Schnaufer A.et al. Association of two novel proteins TbMP52 and TbMP48 with the Trypanosoma brucei RNA editing complex. Mol. Cell Biol. 21:2001;380-389.
10. Schnaufer A., Panigrahi A.K., Panicucci B., Igo R.P. Jr., Salavati R., Stuart K.D. An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei. Science. 291:2001;2159-2162.
11. Igo R.P. Jr., Palazzo S.S., Burgess M.L.K., Panigrahi A.K., Stuart K. Uridylate addition and RNA ligation contribute to the specificity of kinteoplastid insertion RNA editing. Mol. Cell Biol. 20:2000;8447-8457.
12. Blanc V., Alfonzo J.D., Aphasizhev R., Simpson L. The mitochondrial RNA ligase from Leishmania tarentolae can join RNA molecules bridged by a complementary RNA. J. Biol. Chem. 274:1999;24289-24296.
13. McManus M.T., Shimamura M., Grams J., Hajduk S.L. Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. RNA. 7:2001;167-175.
14. Rusché L.N., Huang C.E., Piller K.J., Hemann M., Wirtz E., Sollner-Webb B. The two RNA ligases of the Trypanosoma brucei RNA editing complex: cloning the essential band IV gene and identifying the band V gene. Mol. Cell Biol. 21:2001;979-989.
15. Panigrahi A.K., Schnaufer A., Carmean N., Igo R.P. Jr., Gygi S., Ernst N.et al. Four related proteins of the T. brucei RNA editing complex. Mol. Cell Biol. 21:2001;6833-6840.
16. Drozdz M., Palazzo S.S., Salavati R., O'Rear J., Clayton C., Stuart K. TbMP81 is required for RNA editing in Trypanosoma brucei. EMBO J. 21:2002;1791-1799.
17. Harris M.E., Moore D.R., Hajduk S.L. Addition of uridines to edited RNAs in trypanosome mitochondria occurs independently of transcription. J. Biol. Chem. 265:1990;11368-11376.
18. Salavati R., Panigrahi A.K., Morach B., Palazzo S.S., Igo R.P. Jr., Stuart K.D. Endoribonuclease activities of Trypanosoma brucei mitochondria. Mol. Biochem. Parasitol. 120:2002;23-31.
19. Moore M.J., Query C.C. Joining of RNAs by splinted ligation. Methods Enzymol. 317:2000;109-123.
20. Igo R.P. Jr., Weston D., Ernst N., Panigrahi A.K., Salavati R., Stuart K. Role of uridylate-specific exoribonuclease activity in kinetoplastid RNA editing. Eukaryotic Cell. 1:2002;112-118.
21. Stuart K., Panigrahi A.K. RNA editing: complexity and complications. Mol. Microbiol. 45:2002;591-596.
22. Burgess M.L.K., Stuart K. Sequence bias in edited kinetoplastid RNAs. RNA. 6:2000;1492-1497.
23. Huang C.E., Cruz-Reyes J., Zhelonkina A.G., O'Hearn S., Wirtz E., Sollner-Webb B. Roles for ligases in the RNA editing complex of Trypanosoma brucei: band IV is needed for U-deletion and RNA repair. EMBO J. 20:2001;4694-4703.