Rac 'n Rho: The Music that Shapes a Developing Embryo

Developmental Cell

Volumn 1, Issue 3, 2001, Pages 321-331

  Settleman, Jeffrey ^a  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; BIOLOGICAL MODEL; CELL DIVISION; CELL POLARITY; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NERVE CELL; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; CELL POLARITY; DROSOPHILA MELANOGASTER; EMBRYONIC DEVELOPMENT; GUANOSINE TRIPHOSPHATE; MODELS, BIOLOGICAL; NEURONS; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 0035463289     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(01)00053-3     Document Type: Review

References (66)

1. Allen M.J., Shan X., Murphey R.K. A role for Drosophila Drac1 in neurite outgrowth and synaptogenesis in the giant fiber system. Mol. Cell. Neurosci. 16:2000;754-765.
2. Barrett K., Leptin M., Settleman J. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell. 91:1997;905-915.
3. Blelloch R., Newman C., Kimble J. Control of cell migration during Caenorhabditis elegans development. Curr. Opin. Cell Biol. 11:1999;608-613.
4. Braga V.M., Machesky L.M., Hall A., Hotchin N.A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137:1997;1421-1431.
5. Bray S. Planar polarity. out of joint? Curr. Biol. 10:2000;R155-R158.
6. Brown N.H. Null mutations in the alpha PS2 and beta PS integrin subunit genes have distinct phenotypes. Development. 120:1994;1221-1231.
7. Castrillon D.H., Wasserman S.A. Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene. Development. 120:1994;3367-3377.
8. Chang F. Establishment of a cellular axis in fission yeast. Trends Genet. 17:2001;273-278.
9. Chang H.Y., Ready D.F. Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1. Science. 290:2000;1978-1980.
10. Coleman M.L., Sahai E.A., Yeo M., Bosch M., Dewar A., Olson M.F. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat. Cell Biol. 3:2001;339-345.
11. Chernoff J. Close encounters of the LIM-kinase. Nat. Cell Biol. 1:1999;E115-E117.
12. Costa M., Wilson E.T., Wieschaus E. A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell. 76:1994;1075-1089.
13. Crawford J.M., Harden N., Leung T., Lim L., Kiehart D.P. Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function. Dev. Biol. 204:1998;151-164.
14. Eaton S., Wepf R., Simons K. Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila. J. Cell. Biol. 135:1996;1277-1289.
15. Erickson M.R., Galletta B.J., Abmayr S.M. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J. Cell. Biol. 138:1997;589-603.
16. Fanto M., Weber U., Strutt D.I., Mlodzik M. Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr. Biol. 10:2000;979-988.
17. Genova J.L., Jong S., Camp J.T., Fehon R.G. Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development. Dev. Biol. 221:2000;181-194.
18. Hacker U., Perrimon N. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 12:1998;274-284.
19. Halsell S.R., Chu B.I., Kiehart D.P. Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics. 155:2000;1253-1265.
20. Harden N., Loh H.Y., Chia W., Lim L. A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development. 121:1995;903-914.
21. Harden N., Ricos M., Ong Y.M., Chia W., Lim L. Participation of small GTPases in dorsal closure of the Drosophila embryo. distinct roles for Rho subfamily proteins in epithelial morphogenesis J. Cell. Sci. 112:1999;273-284.
22. Hing H., Xiao J., Harden N., Lim L., Zipursky S.L. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell. 97:1999;853-863.
23. Hunter C.P. Genetics. a touch of elegance with RNAi Curr. Biol. 9:1999;R440-R442.
24. Ishizaki T., Uehata M., Tamechika I., Keel J., Nonomura K., Maekawa M., Narumiya S. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol. Pharmacol. 57:2000;976-983.
25. Jacinto A., Wood W., Balayo T., Turmaine M., Martinez-Arias A., Martin P. Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure. Curr. Biol. 10:2000;1420-1426.
26. Karess R.E., Chang X.J., Edwards K.A., Kulkarni S., Aguilera I., Kiehart D.P. The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila. Cell. 65:1991;1177-1189.
27. Kaufmann N., Wills Z., Vactor D. Drosophila Rac1 controls motor axon guidance. Development. 125:1998;453-461.
28. Kiehart D.P., Galbraith C.G., Edwards K.A., Rickoll W.L., Montague R.A. Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. J. Cell Biol. 149:2000;471-490.
29. Klemke R.L., Leng J., Molander R., Brooks P.C., Vuori K., Cheresh D.A. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J. Cell Biol. 140:1998;961-972.
30. Knaus U.G., Heyworth P.G., Kinsella B.T., Curnutte J.T., Bokoch G.M. Purification and characteization of rac2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J. Biol. Chem. 267:1992;23575-23582.
31. Kosako H., Yoshida T., Matsumura F., Ishizaki T., Narumiya S., Inagaki M. Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene. 19:2000;6059-6064.
32. Kozma R., Sarner S., Ahmed S., Lim L. Rho family GTPases and neuronal growth cone remodelling. relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid Mol. Cell. Biol. 17:1997;1201-1211.
33. Lecuit T., Wieschaus E. Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. J. Cell Biol. 150:2000;849-860.
34. Lee T., Winter C., Marticke S.S., Lee A., Luo L. Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis. Neuron. 25:2000;307-316.
35. Leptin M. Drosophila gastrulation. from pattern formation to morphogenesis Annu. Rev. Cell. Dev. Biol. 11:1995;189-212.
36. Lu Y., Settleman J. The role of rho family GTPases in development. lessons from Drosophila melanogaster Mol. Cell. Biol. Res. Commun. 1:1999;87-94. a.
37. Lu Y., Settleman J. The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev. 13:1999;1168-1180. b.
38. Luo L. Rho GTPases in neuronal morphogenesis. Nat. Rev. Neurosci. 1:2000;173-180. a.
39. Luo L. Trio quartet in D. (melanogaster). Neuron. 26:2000;1-2. b.
40. Luo L., Liao Y.J., Jan L.Y., Jan Y.N. Distinct morphogenetic functions of similar small GTPases. Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion Genes Dev. 8:1994;1787-1802.
41. Magie C.R., Meyer M.R., Gorsuch M.S., Parkhurst S.M. Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development. Development. 126:1999;5353-5364.
42. Moyer B.D., Denton J., Karlson K.H., Reynolds D., Wang S., Mickle J.E., Milewski M., Cutting G.R., Guggino W.B., Li M., Stanton B.A. A PDZ-interacting domain in CFTR is an apical membrane polarization signal. J. Clin. Invest. 104:1999;1353-1361.
43. Murphy A.M., Montell D.J. Cell type-specific roles for CDC42, Rac and RhoL in Drosophilia oogenesis. J. Cell Biol. 133:1996;617-630.
44. Narumiya S., Ishizaki T., Watanabe N. Rho effectors and reorganization of actin cytoskeleton. FEBS Lett. 410:1997;68-72.
45. Nobes C., Hall A. Regulation and function of the Rho subfamily of small GTPases. Curr. Opin. Gen. Dev. 4:1994;77-81.
46. Nobes C.D., Hall A. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81:1995;53-62.
47. Nobes C.D., Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144:1999;1235-1244.
48. Nolan K.M., Barrett K., Lu Y., Hu K.Q., Vincent S., Settleman J. Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev. 12:1998;3337-3342.
49. Noselli S. JNK signaling and morphogenesis in Drosophila. Trends Genet. 14:1998;33-38.
50. Oda H., Tsukita S., Takeichi M. Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation. Dev. Biol. 203:1998;435-450.
51. Otto I.M., Raabe T., Rennefahrt U.E., Bork P., Rapp U.R., Kerkhoff E. The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization. Curr. Biol. 10:2000;345-348.
52. Parks S., Wieschaus E. The Drosophila gastrulation gene concertina encodes a G alpha-like protein. Cell. 64:1991;447-458.
53. Planques V., Warn A., Warn R.M. The effects of microinjection of rhodamine-phalloidin on mitosis and cytokinesis in early stage Drosophila embryos. Exp. Cell Res. 192:1991;557-566.
54. Prokopenko S.N., Brumby A., O'Keefe L., Prior L., He Y., Saint R., Bellen H.J. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 13:1999;2301-2314.
55. Rong Y.S., Golic K.G. A targeted gene knockout in Drosophila. Genetics. 157:2001;1307-1312.
56. Sebbagh M., Renvoize C., Hamelin J., Riche N., Bertoglio J., Breard J. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat. Cell Biol. 3:2001;346-352.
57. Settleman J. Rho GTPases in development. Prog. Mol. Subcell. Biol. 22:1999;201-229.
58. Sone M., Hoshino M., Suzuki E., Kuroda S., Kaibuchi K., Nakagoshi H., Saigo K., Nabeshima Y., Hama C. Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. Science. 275:1997;543-547.
59. Strutt D.I., Weber U., Mlodzik M. The role of RhoA in tissue polarity and Frizzled signalling. Nature. 387:1997;292-295.
60. Su Y.C., Treisman J.E., Skolnik E.Y. The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev. 12:1998;2371-2380.
61. Symons M., Settleman J. Rho family GTPases. more than simple switches Trends Cell Biol. 10:2000;415-419.
62. Tanaka K., Takai Y. Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast. Curr. Opin. Cell Biol. 10:1998;112-116.
63. Van Aelst L., D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 11:1997;2295-2322.
64. Winter C.G., Wang B., Ballew A., Royou A., Karess R., Axelrod J.D., Luo L. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 105:2001;81-91.
65. Wissmann A., Ingles J., McGhee J.D., Mains P.E. Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Genes Dev. 11:1997;409-422.
66. Young P.E., Richman A.M., Ketchum A.S., Kiehart D.P. Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. Genes Dev. 7:1993;29-41.