The role of oxidative stress in paraquat-induced neurotoxicity in rats: Protection by non peptidyl superoxide dismutase mimetic

Neuroscience Letters

Volumn 335, Issue 3, 2003, Pages 163-166

  Mollace, Vincenzo ^a   Iannone, Michelangelo ^b   Muscoli, Carolina ^a   Palma, Emesto ^a   Granato, Teresa ^b   Rispoli, Vincenzo ^a   Nisticò, Robert ^a   Rotiroti, Domenicantonio ^a   Salvemini, Daniela ^c  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

^c MetaPhore Pharmaceuticals   (United States)

Author keywords

Herbicide; Neurotoxicity; Reactive oxygen species; Superoxide dismutase mimetics

Indexed keywords

M 40401; MALONALDEHYDE; OXYGEN RADICAL; PARAQUAT; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN INJURY; CIRCLING BEHAVIOR; CONTROLLED STUDY; ELECTROCORTICOGRAPHY; EPILEPTIC FOCUS; JUMPING; MALE; MOTOR ACTIVITY; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ANIMALS; ELECTROCARDIOGRAPHY; EPILEPSY; FREE RADICALS; HERBICIDES; MALE; MALONDIALDEHYDE; MOTOR ACTIVITY; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; PARAQUAT; RATS; RATS, WISTAR; SUBSTANTIA NIGRA; SUPEROXIDE DISMUTASE;

EID: 0037413657     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)01168-0     Document Type: Article

References (15)

1. Brooks A.I., Chadwick C.A., Gelbard H.A., Cory-Slechta D.A., Federoff H.J. Paraquat elicited neurobehavioural syndrome caused by dopaminergic neuron loss. Brain Res. 823:1999;1-10.
2. Ho Y.S., Magnenat J.L., Gargano M., Cao J. The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ. Health Perspect. 106:1998;1219-1228.
3. lannone M., Ciriolo M.R., Rotilio G., Nistico G. Intra-nigral infusion of Cu-free superoxide dismutase prevents paraquat-induced behavioural stimulation and ECoG epileptogenic discharges in rats. Neuropharmacology. 30:1991;893-898.
4. Ibi M., Sawada H., Kume T., Katsuki H., Kaneko S., Shimohama S., Akaike A. Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons. J. Neurochem. 73:1999;1696-1703.
5. Jha N., Jurma O., Lalli G., Liu Y., Pettus E.H., Greenamyre J.T., Liu R.M., Forman H.J., Andersen J.K. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: implications for Parkinson's disease. J. Biol. Chem. 275:2000;26096-26101.
6. Kim K.S., Choi S.Y., Kwon H.Y., Won M.H., Kang T.C., Kang J.H. Aggregation of aipha-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system. Free Radical Biol. Med. 32:2002;544-550.
7. Mollace V., Nottet H.S.L.M., Clayette P., Turco M.C., Muscoli C., Salvemini D., Perno C.F. Oxidative stress and neuro-AIDS: triggers, modulators and novel antioxidants. Trends Neurosci. 24:2001;411-416.
8. Mollace V., Salvemini D., Riley D.P., Muscoli C., Granato T., Masuelli L., Modesti A., Rotiroti D., Nisticò R., Bertoli A., Perno C.F., Acquaro S. Macrophage secretion of superoxide anions following HIV-1 infection mediates astrocytes apoptosis. J. Leukocyte Biol. 71:2002;65-72.
9. Ohkawa H., Ohishi H., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochem. 95:1979;351-358.
10. Quijano C., Hernandez-Saavedra D., Castro L., McCord J.M., Freeman B.A., Radi R. Reaction of peroxynitrite with Mn-superoxide dismutase; role of the metal center in decomposition kinetics and nitration. J. Biol. Chem. 276:2001;11631-11638.
11. Salvemini D., Riley D.P., Lennon P.J., Wang Z.Q., Currie M.G., Macarthur H., Misko T.P. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. Br. J. Pharmacol. 127:1999;685-692.
12. Salvemini D., Wang Z.Q., Zweier J.L., Samouilov A., Macarthur H., Misko T.P., Curie M.G., Cuzzocrea S., Sikorski J.A., Riley D.P. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science. 8:1999;304-306.
13. Sziraki I., Sershen H., Benuk M., Hashim A., Laitha A. Implications for atypical antioxidative properties of manganese in iron-induced brain lipid peroxidation and copper-dependent low density lipoprotein conjugation. Neurotoxicology. 20:1999;455-466.
14. Thiruchelvam M., Richfield E.K., Baggs R.B., Tank A.W., Cory-Slechta D.A. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J. Neurosci. 20:2000;9207-9214.
15. Yumino K., Kawakami I., Tamura M., Hayashi T., Nakamura M. Paraquat-and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes. J. Biochem. 131:2002;565-570.