Relationship between stereochemistry and the β3-adrenoceptor agonistic activity of 4′-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence

Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2003, Pages 105-112

  Tanaka, Nobuyuki ^a   Tamai, Tetsuro ^a   Mukaiyama, Harunobu ^a   Hirabayashi, Akihito ^a   Muranaka, Hideyuki ^a   Ishikawa, Takehiro ^a   Kobayashi, Junichi ^a   Akahane, Satoshi ^a   Akahane, Masuo ^a  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 CHLORO 4 [2 [[HYDROXY 2 (4 HYDROXYPHENYL) 1 METHYLETHYL]AMINO]ETHYL]PHENOXY]ACETIC ACID; 3 (2 ALLYLPHENOXY) 1 (1,2,3,4 TETRAHYDRONAPHTH 1 YLAMINO) 2 PROPANOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CARBON; HYDROXYL GROUP; NOREPHEDRINE; OXAZOLIDINONE DERIVATIVE; SR 58894A; UNCLASSIFIED DRUG; 2 (2 CHLORO 4 (2 ((2 HYDROXY 2 (4 HYDROXYPHENYL) 1 METHYLETHYL)AMINO)ETHYL)PHENOXY)ACETIC ACID; 2-(2-CHLORO-4-(2-((2-HYDROXY-2-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO)ETHYL)PHENOXY)ACETIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; ETHANOLAMINE DERIVATIVE; ETHYL 2 (2 CHLORO 4 (2 ((2 HYDROXY 2 (4 HYDROXYPHENYL) 1 METHYLETHYL)AMINO)ETHYL)PHENOXY)ACETATE; ETHYL 2-(2-CHLORO-4-(2-((2-HYDROXY-2-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO)ETHYL)PHENOXY)ACETATE; NORADRENALIN; PRODRUG; SR 59104A; TETRALIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER PRESSURE; CHIRALITY; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; MALE; NONHUMAN; POLLAKISURIA; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; URINE INCONTINENCE; ANIMAL; BLADDER; BLOOD PRESSURE; CHEMISTRY; COLON; DRUG EFFECT; DUODENUM; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MICTURITION; MUSCLE CONTRACTION; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PRESSURE; STEREOISOMERISM; SYNTHESIS;

ADMINISTRATION, ORAL; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; COLON; DUODENUM; ETHANOLAMINES; HEART RATE; INJECTIONS, INTRAVENOUS; MALE; MUSCLE CONTRACTION; NOREPINEPHRINE; PRESSURE; PRODRUGS; RATS; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; URINARY BLADDER; URINARY INCONTINENCE; URINATION;

EID: 0037413237     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020177z     Document Type: Article

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