Long-term accumulation of amyloid-β in axons following brain trauma without persistent upregulation of amyloid precursor protein genes

Journal of Neuropathology and Experimental Neurology

Volumn 61, Issue 12, 2002, Pages 1056-1068

  Iwata, Akira ^a   Chen, Xiao Han ^a   McIntosh, Tracy K ^a   Browne, Kevin D ^a   Smith, Douglas H ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer disease; Amyloid precursor protein; Amyloid ; Axonal injury; Brain atrophy; Neurofilament protein; Traumatic brain injury

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; BRAIN INJURY; BRAIN TISSUE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RAT STRAIN; THALAMUS; WESTERN BLOTTING; WHITE MATTER;

EID: 0036898083     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.12.1056     Document Type: Article

References (63)

1. Mortimer JA, Van Duijn CM, Chandra L, et al. Head trauma as a risk factor for Alzheimer's disease: A collaborative re-analysis of case-control studies. Int J Epidemiol 1991;20:S28-S35
2. Nemetz PN, Leibson C, Naessens JM, et al. Traumatic brain injury and time to onset of Alzheimer's disease: A population-based study. Am J Epidem 1999;149:32-40
3. Rasmusson DX, Brandt J, Martin DB, Folstein MF. Head injury as a risk factor in Alzheimer's disease. Brain Inj 1995;3:213-19
4. Schofield PW, Tang M, Marder K, et al. Alzheimer's disease after remote head injury: An incidence study. J Neurol Neurosurg Psychiat 1997;62:119-24
5. Roberts GW, Allsop D, Bruton C. The occult aftermath of boxing. J Neurol Neurosurg Psychiatry 1990;53:373-78
6. Tokuda T, Ikeda S, Yanagisawa N, Ihara Y, Glenner GG. Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein. Acta Neuropathol 1991;82:281-85
7. Graham DI, Gentleman SM, Lynch A, Roberts GW. Distribution of β-amyloid protein in the brain following severe head injury. Neuropath Appl Neurobiol 1995;21:27-34
8. Roberts GW, Gentleman SM, Lynch A, Murray L, Landon M, Graham DI. Beta amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiat 1994;57:419-25
9. Roberts GW, Gentleman SM, Lynch A, Graham DI. βA4 amyloid protein deposition in brain after head trauma. Lancet 1991;338: 1422-23
10. Breteler MM, de Groot RR, van Romunde LK, Hofman A. Risk of dementia in patients with Parkinson's disease, epilepsy, and severe head trauma: A register-based follow-up study. Am J Epidemiol 1995;142:1300-1305
11. Fratiglioni L, Ahlbom A, Viitanen M, Winblad B. Risk factors for late-onset Alzheimer's disease: A population-based, case-control study. Ann Neurol 1993;33:258-66
12. Mehta KM, Ott A, Kalmijn S, et al. Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study. Neurology 1999;53:1959-62
13. Williams DB, Annegers JF, Kokmen E, O'Brien PC, Kurland LT. Brain injury and neurologic sequelae: A cohort study of dementia, parkinsonism, and amyotrophic lateral sclerosis. Neurology 1991; 41:1554-57
14. Adle-Biassette H, Duyckaerts C, Wasowicz M, et al. Beta AP deposition and head trauma. Neurobiology of Aging 1996;17:415-19
15. Pierce JES, Trojanowski JQ, Graham DI, Smith DH, McIntosh TK. Immunohistochemical characterization of alterations in the distribution of amyloid percursor proteins and amyloid β peptide following experimental brain injury in the rat. J Neurosci 1996;16:1083-90
16. Lewen A, Li GL, Nilsson P, Olsson Y, Hillered L. Traumatic brain injury in rat produces changes of β-amyloid precursor protein immunoreactivity. NeuroReport 1995;6:357-60
17. Sherriff FE, Bridges LR, Gentleman SM, Sivaloganathan S, Wilson S. Markers of axonal injury in post mortem human brain. Acta Neuropathol 1994;88:433-39
18. Bramlett HM, Kraydieh S, Green EJ, Dietrich WD. Temporal and regional patterns of axonal damage following traumatic brain injury: A beta-amyloid precursor protein immunocytochemical study in rats. J Neuropathol Exp Neurol 1997;56:1132-41
19. Smith DH, Chen X-H, Nonaka M, et al. Accumulation of amyloid β and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J Neuropathol Exp Neurol 1999;58: 982-92
20. Smith DH, Chen X-H, Pierce JES, et al. Progressive atrophy and neuronal death for one year following brain trauma in the rat. J Neurotrauma 1997;14:715-27
21. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Faden AI. Traumatic brain injury in the rat: Characterization of a lateral fluid percussion model. Neurosci 1989;28:233-44
22. Hayes RL, Stalhammar D, Povlishock JT, et al. A new model of concussive brain injury in the cat produced by extradural fluid volume loading: II. Physiological and neuropathological observations. Brain Inj 1987;1:93-112
23. Dixon CE, Lyeth BG, Povlishock JT, et al. A fluid percussion model of experimental brain injury in the rat. J Neurosurg 1987;67:110-19
24. Leoni MJ, Chen XH, Mueller AL, Cheney J, McIntosh TK, Smith DH. NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat. Exp Neurol 2000; 166:442-49
25. Yamakami I, McIntosh TK. Alterations in regional cerebral blood flow following brain injury in the rat. J Cereb Blood Flow Metab 1991;11:655-60
26. Sola C, Garcia-Ladona FJ, Mengod G, Probst A, Frey P, Palacios JM. Increased levels of the Kunitz protease inhibitor-containing beta APP mRNAs in rat brain following neurotoxic damage. Mol Brain Res 1993;17:41-52
27. Iwata A, Masago A, Yamada K. Expression of basic fibroblast growth factor mRNA after transient focal ischemia: Comparison with expression of c-fos, c-jun, and hsp 70 mRNA. J Neurotrauma 1997;14:201-10
28. Pierce JES, Smith DH, Trojanowski JQ, McIntosh TK. Enduring cognitive, neurobehavioral, and histopathological changes persist for up to one year following severe experimental brain injury in rats. Neurosci 1998;87:359-69
29. Nonaka M, Chen X-H, Pierce JES, et al. Prolonged acitvation of NF-κB following traumatic brain injury in rats. J Neurotrauma 1999;16:1023-34
30. Adams JH, Graham DI, Gennarelli TA. Diffuse axonal injury in non-missile head injury. J Neurol Neurosurg Psychiatry 1991;54: 481-83
31. Smith DH, Meaney DF. Axonal damage in traumatic brain injury. The Neuroscientist 2000;6:483-95
32. Povlishock JT, Becker DP. Fate of reactive axonal swellings induced by head injury. Laboratory Investigation 1985;5:540-52
33. Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: Definition, diagnosis and grading. Histopathology 1989;15:49-59
34. Anderson CV, Bigler ED. Ventricular dilation, cortical atrophy, and neuropsychological outcome following traumatic brain injury. J Neuropsych Clin Neurosci 1995;7:42-48
35. Henry-Feugeas MC, Azouvi P, Fontaine A, et al. MRI analysis of brain atrophy after severe closed-head injury: Relation to clinical status. Brain Inj 2000;14:597-604
36. Povlishock JT, Christman CW. The pathobiology of traumatically induced axonal injury in animals and humans: A review of current thoughts. J Neurotrauma 1995;12:555-64
37. Mrak RE, Sheng JG, Griffin WS. Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease. J Neuropathol Exp Neurol 1996;55:273-79
38. Kalaria RN, Cohen DL, Greenberg BD, et al. Abundance of the longer A beta 42 in neocortical and cerebrovascular amyloid beta deposits in Swedish familial Alzheimer's disease and Down's syndrome. Neuroreport 1996;7:1377-81
39. Gentleman SM, Greenberg BD, Savage MJ, et al. A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury. Neuroreport 1997;8:1519-22
40. Smith DH, Nakamura M, McIntosh TK, et al. Brain trauma induces massive hippocampal neuron death linked to a surge in β-amyloid levels in mice overexpressing mutant amyloid precursor protein. Am J Pathol 1998;153:1005-10
41. Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995;373:523-27
42. Raby CA, Morganti-Kossmann MC, Kossmann T, et al. Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid. J Neurochem 1998;71:2505-9
43. Emmerling MR, Morganti-Kossmann MC, Kossmann T, et al. Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta 42 in human CSE A possible role for nerve cell injury. Ann N Y Acad Sci 2000;903:118-22
44. Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature 1988;331:530-32
45. Ponte P, DeWhitt-Gonzalez P, Schilling J, et al. A new A4 amyloid mRNA contains a domain homologus to serine proteinase inhibitors. Nature 1988;331:525-27
46. Tanzi RE, McClathchey AI, Lamperti ED, Komaroff-Villa L, Gusella JF, Neve RL. Protease inhibitor domain encoded by an amyloid protein precurosr mRNA associated with Alzheimer's disease. Nature 1988;331:528-30
47. Caswell MD, Mok SS, Henry A, et al. The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons. Eur J Biochem 1999;266:509-16
48. Johnson SA, McNeill T, Cordell B, Finch CE. Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease. Science 1990;248:854-57
49. Johnson SA, Rogers J, Einch CE. APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum. Neurobiol Aging 1989;10:755-60
50. Johnson SA, Pasinetti GM, May PC, Ponte PA, Cordell B, Finch CE. Selective reduction of mRNA for the beta-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains. Exp Neurol 1988;102:264-68
51. Johnston JA, Norgren S, Anneren G, Cowburn RF, Lannfelt L. A new quantitative solution hybridisation-RNase protection assay for APP and APLP2 mRNA. Mol Brain Res 1996;43:77-84
52. Spillantini MG, Aloe L, Alleva E, De Simone R, Goedert M, LeviMontalcini R. Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression. Proc Natl Acad Sci USA 1989;86:8555-59
53. Tanaka S, Shiojiri S, Takahashi Y, et al. Tissue-specific expression of three types of beta-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brain. Biochem Biophys Res Commun 1989;165:1406-14
54. Tanaka S, Nakamura S, Ueda K, et al. Three types of amyloid protein precursor mRNA in human brain: Their differential expression in Alzheimer's disease. Biochem Biophys Res Commun 1988; 157:472-79
55. Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987;235:880-84
56. Moir RD, Lynch T, Bush AI, et al. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. J Biol Chem 1998;273:5013-19
57. Abe K, Tanzi RE, Kogure K. Induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistant focal ischemia in rat cerebral cortex. Neurosci Lett 1991; 125:172-74
58. Kalaria RN, Bhatti S, Palatinsky EA, et al. Accumulation of the β amyloid precurosor protein at sites of ischemic injury in rat brain. NeuroReport 1993;4:211-14
59. Koistinaho J, Pyykonen I, Keinanen R, Hokfelt T. Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. NeuroReport 1996;7:2727-31
60. Willoughby DA, Johnson SA, Pasinetti GM, et al. Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus. Exp Neurol 1992:118:332-39
61. Masumura M, Hata R, Uramoto H, Murayama N, Ohno T, Sawada T. Altered expression of amyloid precursors proteins after traumatic brain injury in rats: In situ hybridization and immunohistochemical study. J Neurotrauma 2000;17:123-34
62. Murai H, Pierce JES, Raghupathi R, et al. Two-fold overexpression of human β-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury. J Comp Neurol 1998;392:428-38
63. Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science;1996;274:99-102