Correlation of survival time with size of axonal swellings in diffuse axonal injury

Acta Neuropathologica

Volumn 98, Issue 2, 1999, Pages 197-202

  Wilkinson, A E ^a   Bridges, L R ^a   Sivaloganathan, S ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

amyloid precursor protein; Diffuse axonal injury; Forensic neuropathology; Head injury; Immunohistochemistry

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CELL PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOPSY; BRAIN INJURY; CELL ORGANELLE; CHILD; CORRELATION FUNCTION; FEMALE; FORENSIC PATHOLOGY; HEAD INJURY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; NERVE FIBER DEGENERATION; NEWBORN; PRIORITY JOURNAL; SURVIVAL TIME; WHITE MATTER;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN PRECURSOR; AXONS; BRAIN; CADAVER; CHILD; CHILD, PRESCHOOL; CRANIOCEREBRAL TRAUMA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; MALE; MIDDLE AGED; SURVIVAL ANALYSIS; WOUNDS, NONPENETRATING;

EID: 0032869359     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051069     Document Type: Article

References (17)

1. Adams JH (1992) Head injury. In: Adams JH, Duchen LW (eds) Greenfields' neuropathology, 5th edn. Edward Arnold, London, pp 106-152
2. Adams JH, Graham DI, Gennarelli TA, Maxwell WI (1991) Diffuse axonal injury in non-missile head injury. J Neurol Neurosurg Psychiatry 54:481-483
3. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ (1995) Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury. J Neurotrauma 12:565-572
4. Erb D, Povlishock JT (1988) Axonal damage in severe traumatic brain injury: an experimental study on the cat. Acta Neuropathol 76:347-358
5. Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW (1993) β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury. Neurosci Lett 160: 139-144
6. Gentleman SM, Roberts GW, Gennarelli TA, Maxwell WL, Adams JH, Kerr S, Graham DI (1995) Axonal injury: a universal consequence of fatal closed head injury. Acta Neuropathol 89:537-543
7. Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT (1993) The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol 52: 143-152
8. Graham DI, Lawrence AE, Adams JH, Doyle D, McLellan DR (1987) Brain damage in non-missile head injury secondary to high intracranial pressure. Neuropathol Appl Neurobiol 13: 209-217
9. Koo EH, Sisoda SS, Archer DR, Martin LJ, Weidmann A, Beyreuther K, Fischer P, Masters CL, Price DL (1990) Precursor of amyloid protein in Alzheimer's disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci USA 87: 1561-1565
10. McKenzie KJ, McLellan DR, Gentleman SM, Maxwell WL, Gennarelli TA, Graham DI (1996) Is β-APP a marker of axonal damage in short-surviving head injury? Acta Neuropathol 92: 608-613
11. Neve RL, Finch EA, Dawes LR (1988) Expression of the Alzheimer's amyloid precursor gene transcripts in the human brain. Neuron 1:669-677
12. Otsuka N, Tomonaga M, Ikeda K (1991) Rapid appearance of beta-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury. Brain Res 568:335-338
13. Pilz P (1983) Axonal injury in head injury. Acta Neurochir (Wien) [Suppl] 32:119-123
14. Povlishock JT, Jenkins LW (1995) Are the pathobiological changes evoked by traumatic brain injury immediate and irreversible? Brain Pathol 5:415-426
15. Sherriff FE, Bridges LR, Sivaloganathan S (1994) Early detection of axonal injury after human head trauma using immunocytochemistry for β-amyloid precursor protein. Acta Neuropathol 87:55-62
16. Strich SJ (1961) Shearing of nerve fibres as a cause of brain damage due to head injury. Lancet II:443-448
17. Yaghmai A, Povlishock J (1992) Traumatically induced reactive change as visualized through the use of neurofilament subunits. J Neuropathol Exp Neurol 51:158-176