2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT4 receptor: Synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives

Journal of Medicinal Chemistry

Volumn 42, Issue 15, 1999, Pages 2870-2880

  Tapia, Inés ^a   Alonso Cires, Luisa ^a   López Tudanca, Pedro Luis ^a   Mosquera, Ramón ^a   Labeaga, Luis ^a   Innerárity, Ana ^a   Orjales, Aurelio ^a  

^a FAES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CARBACHOL; DOPAMINE 2 RECEPTOR; METHYL GROUP; PIPERAZINE DERIVATIVE; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BENZIMIDAZOLES; CORPUS STRIATUM; ENTORHINAL CORTEX; ESOPHAGUS; GUINEA PIGS; MALE; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033614953     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981098j     Document Type: Article

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