Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor V(β) profiles

British Journal of Haematology

Volumn 102, Issue 5, 1998, Pages 1314-1322

  Molldrem, Jeffrey J ^a,d   Jiang, Yin Zheng ^b   Stetler Stevenson, Maryalice ^c   Mavroudis, Dimitrios ^b   Hensel, Nancy ^b   Barrett, A John ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Bone marrow; Immunosuppresion; Myelodysplastic syndrome; T lymphocytes

Indexed keywords

CD8 ANTIGEN; PREDNISONE; T LYMPHOCYTE RECEPTOR; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; BONE MARROW SUPPRESSION; CLINICAL ARTICLE; CLINICAL TRIAL; COLONY FORMING UNIT GM; FEMALE; HUMAN; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MALE; MYELODYSPLASTIC SYNDROME; PANCYTOPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

ADULT; ANTILYMPHOCYTE SERUM; BONE MARROW CELLS; CD8-POSITIVE T-LYMPHOCYTES; COLONY-FORMING UNITS ASSAY; FEMALE; HUMANS; LYMPHOPENIA; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 7344223859     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00920.x     Document Type: Article

References (20)

1. Bagby, G.C., Gabourel, J.D. & Linman, J.W. (1980) Gluticocorticoid therapy in the preleukemic syndrome (hemopoietic dysplasia). Annals of Internal Medicine, 92, 55-58.
2. Duhrsen, U. & Hossfeld, D.K. (1996) Stromal abnormalities in neoplastic bone marrow diseases. Annals of Hematology, 73, 53-70.
3. Genestier, L., Fournel, S., Flacher, M., Assossou, O., Revillard, J. & Bonnefoy-Berard, N. (1998) Induction of fas (Apo-1, CD95)-mediated apoptosis of activated lymphocytes by polyclonal antithymocyte globulins. Blood, 91, 2360-2368.
4. Jiang, Y.Z., Mavroudis, D.A., Dermime, S., Molldrem, J., Hensel, N.F. & Barrett, A.J. (1997) Preferential usage of T cell receptor (TCR) V beta by allogeneic T cells recognizing myeloid leukemia cells: implications for separating graft-versus-leukemia effect from graft-versus-host disease. Bone Marrow Transplantation, 19, 899-903.
5. Lepelley, P., Campergue, L., Grardel, N., Preudhomme, C., Cosson, A. & Fenaux, P. (1996) Is apoptosis a massive process in myelodysplastic syndromes? British Journal of Haematology, 95, 368-371.
6. Molldrem, J.J., Caples, M. Mavroudis, D., Plante, M., Young, N.S. & Barrett, A.J. (1997) Antithymocyte globulin for patients with myelodysplastic syndrome. British Journal of Haematology, 99, 699-705.
7. Nimer, S.D., Golde, D.W., Kwan, K., Lee, K., Clark, S. & Camplin, R. (1991) In vitro production of granulocyte-macrophage colony-stimulating factor in aplastic anemia: possible mechanisms of action of antithymocyte globulin. Blood, 78, 163-168.
8. Plantanias, L., Gascon, P., Bielory, L., Griffith, P. Nienhuis, A.W. & Young, N.S. (1987) Lymphocyte subsets and lymphokines following anti-thymocyte globulin therapy in patients with aplastic anaemia. British Journal of Haematology, 66, 433-443.
9. Rajapaksa, R., Ginzton, N., Rott, L.S. & Greenberg, P.L. (1996) Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood, 88, 4275-4287.
10. Raza, A., Gezer, S., Mundle, S., Gao, X.Z., Alvi, S., Borok, R., Rifkin, S., Iftikhar, A., Shetty, V. & Parcharidou, A. (1995) Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 86, 268-276.
11. Raza, A., Mundle, S., Shetty, V., Alvi, S., Chopra, H., Span, L., Parcharidou, A., Dar, S., Venugopal, P., Borok, R., Gezer, S., Showel, J., Loew, J., Robin, E., Rifkin, S., Alston, D., Hernandez, B., Shah, R., Kaizer, H. & Gregory, S. (1996) Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines. International Journal of Hematology, 63, 265-278.
12. + cells. Leukemia and Lymphoma, 22, 43-51.
13. Selleri, C., Sato, T., Del Vecchio, L., Luciano, L., Barrett, A.J., Rotoli, B. & Young, N.S. (1997) Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood, 89, 957-964.
14. Smith, A.G., O'Reilly, R.J., Hansen, J.A. & Martin, P.J. (1985) Specific antibody-blocking activities in antilymphocyte globulin as correlates of efficacy for the treatment of aplastic anemia. Blood, 66, 721-723.
15. Smith, M.A. & Smith, J.G. (1991) The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: an in vitro study. Leukemia Research, 15, 597-601.
16. Sugawara, T., Endo, K., Shishido, T., Sato, A., Kameoka, J., Fukuhara, O., Yoshinaga, K. & Miura, A. (1992) T cell-mediated inhibition of erythropoiesis in myelodysplastic syndromes. American Journal of Hematology, 41, 304-305.
17. Tichelli, A., Gratwohl, A., Wuersch, A., Nissen, C. & Speck, B. (1988) Antilymphocyte globulin for myelodysplastic syndrome? British Journal of Haematology, 68, 139-140.
18. Tong, J., Bacigalupo, A., Piaggio, G., Figari, O., Sogno, G. & Marmont, A. (1991) In vitro response of T cells from aplastic anemia patients to antilymphocyte globulin and phytohemagglutinin: colony-stimulating activity and lymphokine production. Experimental Hematology, 19, 312-316.
19. Weimar, I.S., Bourhis, J.H., De Gast, G.C. & Gerritsen, W.R. (1994) Clonality in myelodysplastic syndromes. Leukemia and Lymphoma, 13, 215-221.
20. Young, N., Griffith, R. Brittain, E., Elfenbein, G., Gardner, F., Huang, A., Harmon, D., Hewlett, J., Fay, J. & Mangan, K. (1988) A multicenter trial of antithymocyte globulin in aplastic anemia and related diseases. Blood, 72, 1861-1869.